| UniProt ID | ITM2C_MOUSE | |
|---|---|---|
| UniProt AC | Q91VK4 | |
| Protein Name | Integral membrane protein 2C | |
| Gene Name | Itm2c | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 269 | |
| Subcellular Localization |
Lysosome membrane Single-pass type II membrane protein . Cell membrane Single-pass type II membrane protein. |
|
| Protein Description | Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.. | |
| Protein Sequence | MVKISFQPAVAGIKADKADKAAASGPASASAPAAEILLTPAREERPPRHRSRKGGSVGGVCYLSMGMVVLLMGLVFASVYIYRYFFLAQLARDNFFHCGVLYEDSLSSQIRTRLELEEDVKIYLEENYERINVPVPQFGGGDPADIIHDFQRGLTAYHDISLDKCYVIELNTTIVLPPRNFWELLMNVKRGTYLPQTYIIQEEMVVTEHVRDKEALGSFIYHLCNGKDTYRLRRRSTRRRINKRGGKNCNAIRHFENTFVVETLICGVV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Ubiquitination | -----MVKISFQPAV -----CCEEEECCCC | 31.19 | - | |
| 14 | Ubiquitination | QPAVAGIKADKADKA CCCCCCCCCCHHHHH | 50.00 | 27667366 | |
| 17 | Ubiquitination | VAGIKADKADKAAAS CCCCCCCHHHHHHHC | 64.44 | 27667366 | |
| 20 | Ubiquitination | IKADKADKAAASGPA CCCCHHHHHHHCCCC | 44.80 | 27667366 | |
| 39 | Phosphorylation | PAAEILLTPAREERP CHHHHHCCCCCCCCC | 16.08 | 21082442 | |
| 96 | Ubiquitination | QLARDNFFHCGVLYE HHHHHCCEEEEEEEC | 6.13 | 27667366 | |
| 99 | Ubiquitination | RDNFFHCGVLYEDSL HHCCEEEEEEECHHH | 12.14 | 27667366 | |
| 102 | Ubiquitination | FFHCGVLYEDSLSSQ CEEEEEEECHHHHHH | 18.45 | 27667366 | |
| 107 | Phosphorylation | VLYEDSLSSQIRTRL EEECHHHHHHHHHHC | 24.93 | 28285833 | |
| 108 | Phosphorylation | LYEDSLSSQIRTRLE EECHHHHHHHHHHCC | 34.61 | 28285833 | |
| 112 | Phosphorylation | SLSSQIRTRLELEED HHHHHHHHHCCHHHH | 41.03 | 28285833 | |
| 166 | Phosphorylation | DISLDKCYVIELNTT ECCCCCEEEEEECCE | 15.37 | 24719451 | |
| 171 | N-linked_Glycosylation | KCYVIELNTTIVLPP CEEEEEECCEEEECC | 23.53 | - | |
| 173 | Phosphorylation | YVIELNTTIVLPPRN EEEEECCEEEECCCC | 14.17 | 24719451 | |
| 198 | Phosphorylation | GTYLPQTYIIQEEMV CCCCCCEEEEEEEEE | 7.26 | 28059163 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ITM2C_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ITM2C_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ITM2C_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ITM2C_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-39, AND MASSSPECTROMETRY. | |
