UCRI_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UCRI_MOUSE
• UniProt AC: Q9CR68
• Protein Name: Cytochrome b-c1 complex subunit Rieske, mitochondrial
• Gene Name: Uqcrfs1 {ECO:0000312|MGI:MGI:1913944}
• Organism: Mus musculus (Mouse).
• Sequence Length: 274
• Subcellular Localization: Mitochondrion inner membrane ; Single-pass membrane protein .
• Protein Description: Cytochrome b-c1 complex subunit Rieske, mitochondrial: Component of the mitochondrial ubiquinol-cytochrome c reductase complex dimer (complex III dimer), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. [PubMed: 28673544 Incorporation of UQCRFS1 is the penultimate step in complex III assembly (By similarity; Cytochrome b-c1 complex subunit 9: Possible component of the mitochondrial ubiquinol-cytochrome c reductase complex dimer (complex III dimer), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis]
• Protein Sequence: MLSVAARSGPFAPVLSATSRGVAGALRPLLQGAVPAASEPPVLDVKRPFLCRESLSGQAAARPLVATVGLNVPASVRFSHTDVKVPDFSDYRRAEVLDSTKSSKESSEARKGFSYLVTATTTVGVAYAAKNVVSQFVSSMSASADVLAMSKIEIKLSDIPEGKNMAFKWRGKPLFVRHRTKKEIDQEAAVEVSQLRDPQHDLDRVKKPEWVILIGVCTHLGCVPIANAGDFGGYYCPCHGSHYDASGRIRKGPAPLNLEVPAYEFTSDDVVVVG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	QGAVPAASEPPVLDV CCCCCCCCCCCCCCC	53.38	27180971
46	Acetylation	EPPVLDVKRPFLCRE CCCCCCCCCCCCCCH	54.76	23201123
51	S-nitrosocysteine	DVKRPFLCRESLSGQ CCCCCCCCCHHHCCC	4.67	-
51	S-nitrosylation	DVKRPFLCRESLSGQ CCCCCCCCCHHHCCC	4.67	21278135
91	Phosphorylation	KVPDFSDYRRAEVLD CCCCHHHHHHHHHHH	10.78	25195567
99	Phosphorylation	RRAEVLDSTKSSKES HHHHHHHCCCCCHHC	33.31	28464351
101	Acetylation	AEVLDSTKSSKESSE HHHHHCCCCCHHCHH	57.60	23954790
102	Phosphorylation	EVLDSTKSSKESSEA HHHHCCCCCHHCHHH	46.89	20139300
114	Phosphorylation	SEARKGFSYLVTATT HHHHHCCEEEEEEEC	26.65	22871156
121	Phosphorylation	SYLVTATTTVGVAYA EEEEEEECHHHHHHH	19.61	22871156
155	Ubiquitination	AMSKIEIKLSDIPEG HEECEEEEHHHCCCC	29.19	22790023
155	Acetylation	AMSKIEIKLSDIPEG HEECEEEEHHHCCCC	29.19	24062335
163	Acetylation	LSDIPEGKNMAFKWR HHHCCCCCCCCEEEC	41.72	23864654
163	Ubiquitination	LSDIPEGKNMAFKWR HHHCCCCCCCCEEEC	41.72	22790023
168	Succinylation	EGKNMAFKWRGKPLF CCCCCCEEECCEEEE	26.83	26388266
168	Acetylation	EGKNMAFKWRGKPLF CCCCCCEEECCEEEE	26.83	24062335
172	Ubiquitination	MAFKWRGKPLFVRHR CCEEECCEEEEEECC	29.94	27667366
181	Acetylation	LFVRHRTKKEIDQEA EEEECCCHHHCCHHH	48.65	23864654
182	Acetylation	FVRHRTKKEIDQEAA EEECCCHHHCCHHHH	60.33	24062335
193	Phosphorylation	QEAAVEVSQLRDPQH HHHHHHHHHHCCCCC	15.25	19060867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UCRI_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UCRI_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UCRI_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of UCRI_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.