| UniProt ID | CLGN_MOUSE | |
|---|---|---|
| UniProt AC | P52194 | |
| Protein Name | Calmegin | |
| Gene Name | Clgn | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 611 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass type I membrane protein . |
|
| Protein Description | Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions.. | |
| Protein Sequence | MRFQGVGLCLGLLFITVNADFMDDGVEVEDFSENSDESNIKDEPSSGTFKYKTPQPIGEVYFTETFDSGNLAGWVLSKAKKDDMDSEIAIYDGRWEIEELKENQVPGDRGLVLKSKAKHHAIAAVLEKPFIFADKPLIVQYEVNFQDGIDCGGAYIKLLADTGDLILENFYDKTSYTIMFGPDKCGEDYKLHLIFRHKHPKTGVFEEKHAKPPDVDLKEFFTDRKTHLYTLVMNPDDTFEVLIDQKVVNQGTLLDDVVPPINPPREIDDPSDKKPEEWDDRAKIPDPTAVRPEDWDENEPAQIEDSSAVKPDGWLDDEPKFIPNPKAEKPEDWSDDMDGEWEAPHIPNPACQIGCGEWKPPMIDNPKYKGIWRPPMINNPNYQGLWSPQKIPNPDYFEDDHPFLLTSFSALGLELWSMTPDIYFDNFIICSEKEVADQWATDGWELKIMVANANEPGVLRQLVIAAEERPWLWLMYLVMAGLPVALVASFCWPRKVKKKYEDTGPKKTELCKLQSKAALEQEAEEEKAPEKPEDVQEEKKPGEAEVVTVEKEVIGEPEEKSKEDRETLEGQEEVSKLSKSGSEDEMKDADESPGSGDAPLKSLRKRRVRKD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 128 | Acetylation | AIAAVLEKPFIFADK HHHHHHCCCEEECCC | 40.86 | - | |
| 306 | Phosphorylation | EPAQIEDSSAVKPDG CCCCCCCCCCCCCCC | 13.86 | 26239621 | |
| 307 | Phosphorylation | PAQIEDSSAVKPDGW CCCCCCCCCCCCCCC | 49.78 | 26239621 | |
| 387 | Phosphorylation | PNYQGLWSPQKIPNP CCCCCCCCCCCCCCC | 23.61 | 30635358 | |
| 561 | Phosphorylation | IGEPEEKSKEDRETL CCCCCCCCHHHHHHH | 44.55 | - | |
| 562 | Ubiquitination | GEPEEKSKEDRETLE CCCCCCCHHHHHHHH | 74.77 | - | |
| 567 | Phosphorylation | KSKEDRETLEGQEEV CCHHHHHHHHHHHHH | 30.88 | - | |
| 575 | Phosphorylation | LEGQEEVSKLSKSGS HHHHHHHHHHHCCCC | 31.03 | 27841257 | |
| 578 | Phosphorylation | QEEVSKLSKSGSEDE HHHHHHHHCCCCHHH | 28.63 | 22817900 | |
| 580 | Phosphorylation | EVSKLSKSGSEDEMK HHHHHHCCCCHHHHC | 44.14 | 21149613 | |
| 582 | Phosphorylation | SKLSKSGSEDEMKDA HHHHCCCCHHHHCCC | 49.30 | 25521595 | |
| 592 | Phosphorylation | EMKDADESPGSGDAP HHCCCCCCCCCCCCC | 34.80 | 25521595 | |
| 595 | Phosphorylation | DADESPGSGDAPLKS CCCCCCCCCCCCHHH | 36.56 | 22817900 | |
| 602 | Phosphorylation | SGDAPLKSLRKRRVR CCCCCHHHHHHHHCC | 40.88 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CLGN_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CLGN_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CLGN_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of CLGN_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
