| UniProt ID | CDKAL_MOUSE | |
|---|---|---|
| UniProt AC | Q91WE6 | |
| Protein Name | Threonylcarbamoyladenosine tRNA methylthiotransferase | |
| Gene Name | Cdkal1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 578 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass membrane protein. Is a tail-anchored protein that exploits the TCR40 assisted pathway for insertion into the endoplasmic reticulum.. |
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| Protein Description | Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.. | |
| Protein Sequence | MPSASCDVLLDDIEDIISQEDSKPQDRQFSRKHVFPKVRRRNTQKYLQEEPRPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKVVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGKRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVERAKQSFQEGVCEIWLTSEDTGAYGRDIGTDLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMDMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKAEQVPAHVKKQRTKDLSRVFHSYNPYDHKIGERQQVLVTEESFDSKFYVAHNRFYEQVLVPKNPAFMGKMVEVDIYESGKHFLKGQPVSETRVYTPSISKPLAKGEVSGLTKEFRNRLGNHPNGTSDTCPATQHGSAYSRMVLQMSQYDCALKVATGLALLALLLHFWPDSLLTM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 121 | Phosphorylation | AEDHFRNSIKKAQEE HHHHHHHHHHHHHHH | 31.37 | - | |
| 186 | Acetylation | GQKKDNGKRLGGARL EEECCCCCCCCCCCC | 51.18 | 7844479 | |
| 218 | Ubiquitination | TGCLNACTYCKTKHA CCCHHHHHHHCCCCC | 29.55 | 27667366 | |
| 265 | Ubiquitination | DTGAYGRDIGTDLPT CCCCCCCCCCCCHHH | 39.03 | 27667366 | |
| 314 | Phosphorylation | ILNHPRVYAFLHIPV HHCCCEEEEEEECCC | 7.91 | 25777480 | |
| 323 | Phosphorylation | FLHIPVQSASDSVLM EEECCCCCCCCCHHH | 29.94 | 25777480 | |
| 325 | Phosphorylation | HIPVQSASDSVLMDM ECCCCCCCCCHHHHH | 35.35 | 25777480 | |
| 327 | Phosphorylation | PVQSASDSVLMDMKR CCCCCCCCHHHHHCH | 18.04 | 25777480 | |
| 494 | Phosphorylation | KGQPVSETRVYTPSI CCCCCCEEEEECCCC | 20.23 | 24719451 | |
| 498 | Phosphorylation | VSETRVYTPSISKPL CCEEEEECCCCCCCC | 14.01 | 26643407 | |
| 500 | Phosphorylation | ETRVYTPSISKPLAK EEEEECCCCCCCCCC | 31.52 | 26643407 | |
| 503 | Ubiquitination | VYTPSISKPLAKGEV EECCCCCCCCCCCCC | 42.24 | 27667366 | |
| 515 | Ubiquitination | GEVSGLTKEFRNRLG CCCCCCCHHHHHHHC | 60.95 | 22790023 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CDKAL_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CDKAL_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CDKAL_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of CDKAL_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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