PI3R4_MOUSE - dbPTM
PI3R4_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PI3R4_MOUSE
UniProt AC Q8VD65
Protein Name Phosphoinositide 3-kinase regulatory subunit 4
Gene Name Pik3r4
Organism Mus musculus (Mouse).
Sequence Length 1358
Subcellular Localization Late endosome. Cytoplasmic vesicle, autophagosome . Membrane
Lipid-anchor . As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes. Localizes also to di
Protein Description Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity)..
Protein Sequence MGNQLAGIAPSQILSVESYFSDIHDFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLHSAQNCLPFQKAAEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRARGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLLAYRNGHFFPEQVLNKIEDRSIRDLVTQMINREPEKRLEAEDYLKQQRGNAFPEIFYTFLQPYMAQFAKETFLSADERILVIRKDLGNIIHNLCGHDLPEKAEGESRASGLVVLVSVITSCLQTLKSCDSKLAALELILHLAPRLSVEILLDRITPYLLHFSNDSVPRVRAEALRTLTKVLALVQEVPRNDVNIYPEYILPGIAHLAQDDATIVRLAYAENIALLAETALRFLELVQLKTLNMENEPDNEEVDEATRPNGDYDTELQALHEMVQQKVVTLLSDPENIVKQTLMESGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDSIVGVAAYVGWQSSSILKPLLQQGLSDAEEFVIVKALNALTCMCQLGLLQKPHVYEFASDIAPFLCHPNLWIRYGAVGFITVVAHQISTADVYCKLMPYLDPYITQPVIQIERKLVLLSVLKEPVSRSIFDYALRSKDIASLFRHLHMRQKKRNGSLLDCPPPEDPTIAQLLKKLLSQGMTEEEEDKLLALKDFMMKSNRAKANAVDQSHLHDSSQKGVIDLAALGITGRQVDLVKTKQEPDEKRARKHVKQDSNVNEEWKSMFGSLEPPNIPQALPKTSDHEVVQPGKPPRSESSAGICVPLSTSPQVSEAAHIPSKKPVIPVVSSTVLPSTYQIRITTCKTELQQLIQQKREQCNAERIAKQMMENAEWESKPPPPGWRPKGLLVAHLHEHKSAVNRIRVSDEHLLFATCSNDGTVKIWNSQKMEGKTTTTRSILTYSRIGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASKLPKSPKIHPLQSRILDQKEDGCVVDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLKSGLITSFAVDIHQCWLCIGTSSGAMACWDMRFQLPISSHCHPSRARIRRLSMHPLYQSWVIAAVQGNNEVSMWDMETGDRRLTLWASSAPPLSELQPSPHSVHGIYCSPADGNPILLTAGSDMKIRFWDLVSPERSYVVAGSTGSPSVSYYKKIIEGTEVVQEIQNKQKVGPSDDTPRRGPESLPVGHHDIITDIATFQTTQGFIVTASRDGIVKVWK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Myristoylation------MGNQLAGIA
------CCCCCCCCC		41.73-
75UbiquitinationKQELEELKIRLHSAQ
HHHHHHHHHHHHHHH		29.12-
89UbiquitinationQNCLPFQKAAEKASE
HCCHHHHHHHHHHHH		50.36-
97UbiquitinationAAEKASEKAAMLFRQ
HHHHHHHHHHHHHHH		38.66-
267PhosphorylationDLSQLLAYRNGHFFP
CHHHHHHHHCCCCCH		12.46-
300UbiquitinationMINREPEKRLEAEDY
HHCCCHHHHHHHHHH		73.35-
309UbiquitinationLEAEDYLKQQRGNAF
HHHHHHHHHHHCCCC		37.85-
410PhosphorylationLHLAPRLSVEILLDR
HHHHHHCCHHHHHHH		20.9825521595
543PhosphorylationMVQQKVVTLLSDPEN
HHHHHHHHHHCCHHH		25.6022817900
546PhosphorylationQKVVTLLSDPENIVK
HHHHHHHCCHHHHHH		54.9922817900
555O-linked_GlycosylationPENIVKQTLMESGIT
HHHHHHHHHHHCCCC		23.5030059200
555PhosphorylationPENIVKQTLMESGIT
HHHHHHHHHHHCCCC		23.5022817900
559PhosphorylationVKQTLMESGITRLCV
HHHHHHHCCCCHHHH		22.8722817900
808PhosphorylationKANAVDQSHLHDSSQ
HCCCCCHHHCCCCCC		24.45-
813PhosphorylationDQSHLHDSSQKGVID
CHHHCCCCCCCCCCH		24.7425521595
814PhosphorylationQSHLHDSSQKGVIDL
HHHCCCCCCCCCCHH		41.8029472430
850UbiquitinationKRARKHVKQDSNVNE
HHHHHHHHCCCCCCH		48.37-
853PhosphorylationRKHVKQDSNVNEEWK
HHHHHCCCCCCHHHH		39.9425521595
861PhosphorylationNVNEEWKSMFGSLEP
CCCHHHHHHHCCCCC		22.0326745281
865PhosphorylationEWKSMFGSLEPPNIP
HHHHHHCCCCCCCCC		20.4927180971
892PhosphorylationQPGKPPRSESSAGIC
CCCCCCCCCCCCCEE		47.8325619855
894PhosphorylationGKPPRSESSAGICVP
CCCCCCCCCCCEEEE		27.0822942356
895PhosphorylationKPPRSESSAGICVPL
CCCCCCCCCCEEEEC		26.8525619855
903PhosphorylationAGICVPLSTSPQVSE
CCEEEECCCCCCHHH		22.2925619855
904PhosphorylationGICVPLSTSPQVSEA
CEEEECCCCCCHHHH		52.7025619855
905PhosphorylationICVPLSTSPQVSEAA
EEEECCCCCCHHHHC		15.2325521595
909PhosphorylationLSTSPQVSEAAHIPS
CCCCCCHHHHCCCCC		19.1025619855
916PhosphorylationSEAAHIPSKKPVIPV
HHHCCCCCCCCCEEE		53.3525619855
925PhosphorylationKPVIPVVSSTVLPST
CCCEEEEECCCCCCC		22.1129514104
927PhosphorylationVIPVVSSTVLPSTYQ
CEEEEECCCCCCCEE		20.6825338131
951MalonylationLQQLIQQKREQCNAE
HHHHHHHHHHHHCHH		41.3426320211
951AcetylationLQQLIQQKREQCNAE
HHHHHHHHHHHHCHH		41.3415608207
1022PhosphorylationGTVKIWNSQKMEGKT
CCEEEEECCCCCCCC		19.0429895711
1037PhosphorylationTTTRSILTYSRIGGR
CCCHHHHEEEEECCE		20.1325619855
1038PhosphorylationTTRSILTYSRIGGRV
CCHHHHEEEEECCEE		7.7825619855
1039PhosphorylationTRSILTYSRIGGRVK
CHHHHEEEEECCEEE		16.5225619855
1079PhosphorylationEASKLPKSPKIHPLQ
EHHHCCCCCCCCCCH		29.5022871156
1087PhosphorylationPKIHPLQSRILDQKE
CCCCCCHHHHCCCCC		29.0422871156
1292UbiquitinationSPSVSYYKKIIEGTE
CCCHHHHHHHHCCCH		29.30-
1313PhosphorylationNKQKVGPSDDTPRRG
HCCCCCCCCCCCCCC		42.0428066266
1316PhosphorylationKVGPSDDTPRRGPES
CCCCCCCCCCCCCCC		24.5628066266
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PI3R4_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PI3R4_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PI3R4_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PI3R4_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PI3R4_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-894 AND SER-905, ANDMASS SPECTROMETRY.

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