SPTC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPTC1_MOUSE
• UniProt AC: O35704
• Protein Name: Serine palmitoyltransferase 1
• Gene Name: Sptlc1
• Organism: Mus musculus (Mouse).
• Sequence Length: 473
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass membrane protein .
• Protein Description: Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates. The SPTLC1-SPTLC2-SPTSSB complex displays a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme has the ability to use a broader range of acyl-CoAs (By similarity)..
• Protein Sequence: MATVAEQWVLVEMVQALYEAPAYHLILEGILILWIIRLVFSKTYKLQERSDLTAKEKEELIEEWQPEPLVPPVSKNHPALNYNIVSGPPTHNIVVNGKECVNFASFNFLGLLANPRVKATAFSSLKKYGVGTCGPRGFYGTFDVHLDLEERLAKFMKTEEAIIYSYGFSTIASAIPAYSKRGDIIFVDSAACFAIQKGLQASRSDIKLFKHNDVADLERLLKEQEIEDQKNPRKARVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGISIDDIDLISANMENALASVGGFCCGRSFVVDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPDIFAVLKKKCQNIHKSLQGVSGLKVVGESLSPALHLQLEESTGSREKDVKLLQAIVDQCMDKGIALTQARYLDKEEKCLPPPSIRVVVTVEQTEEELQRAASTIREAAQAVLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Phosphorylation	TYKLQERSDLTAKEK CCCCHHHCCCCHHHH	35.90	26643407
86	Phosphorylation	ALNYNIVSGPPTHNI CCCCCCCCCCCCCEE	41.61	-
158	Phosphorylation	RLAKFMKTEEAIIYS HHHHHHCCCCHHHHH	27.54	23984901
164	Phosphorylation	KTEEAIIYSYGFSTI CCCCHHHHHCCHHHH	6.96	23984901
165	Phosphorylation	TEEAIIYSYGFSTIA CCCHHHHHCCHHHHH	14.36	23984901
166	Phosphorylation	EEAIIYSYGFSTIAS CCHHHHHCCHHHHHH	12.76	23984901
169	Phosphorylation	IIYSYGFSTIASAIP HHHHCCHHHHHHHCH	17.97	23984901
170	Phosphorylation	IYSYGFSTIASAIPA HHHCCHHHHHHHCHH	20.50	23984901
173	Phosphorylation	YGFSTIASAIPAYSK CCHHHHHHHCHHHCC	23.92	23984901
178	Phosphorylation	IASAIPAYSKRGDII HHHHCHHHCCCCCEE	14.90	23984901
179	Phosphorylation	ASAIPAYSKRGDIIF HHHCHHHCCCCCEEE	20.27	23984901
222	Ubiquitination	ADLERLLKEQEIEDQ HHHHHHHHHHHHHHC	63.04	22790023
230	Ubiquitination	EQEIEDQKNPRKARV HHHHHHCCCHHHHHH	79.73	27667366
375	Ubiquitination	KKCQNIHKSLQGVSG HHHHHHHHHHCCCCC	49.41	22790023
376	Phosphorylation	KCQNIHKSLQGVSGL HHHHHHHHHCCCCCC	16.26	29109428
438	Glutathionylation	YLDKEEKCLPPPSIR HCCHHHCCCCCCCEE	8.57	24333276
443	Phosphorylation	EKCLPPPSIRVVVTV HCCCCCCCEEEEEEE	28.88	29899451
449	Phosphorylation	PSIRVVVTVEQTEEE CCEEEEEEECCCHHH	13.50	29899451
453	Phosphorylation	VVVTVEQTEEELQRA EEEEECCCHHHHHHH	31.68	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
164	Y	Phosphorylation	Kinase	ABL	P00520	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPTC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPTC1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ABCA1_MOUSE	Abca1	physical	18484747
PARD3_MOUSE	Pard3	physical	18484747

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.