dbPTM

ABCA1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ABCA1_MOUSE
UniProt AC	P41233
Protein Name	ATP-binding cassette sub-family A member 1
Gene Name	Abca1
Organism	Mus musculus (Mouse).
Sequence Length	2261
Subcellular Localization	Membrane Multi-pass membrane protein .
Protein Description	cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport (By similarity)..
Protein Sequence	MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVSRLFSDAQRLLLYSQRDTSIKDMHKVLRMLRQIKHPNSNLKLQDFLVDNETFSGFLQHNLSLPRSTVDSLLQANVGLQKVFLQGYQLHLASLCNGSKLEEIIQLGDAEVSALCGLPRKKLDAAERVLRYNMDILKPVVTKLNSTSHLPTQHLAEATTVLLDSLGGLAQELFSTKSWSDMRQEVMFLTNVNSSSSSTQIYQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNNTEEDVDTFYDNSTTPYCNDLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELSPQIWTFMENSQEMDLVRTLLDSRGNDQFWEQKLDGLDWTAQDIMAFLAKNPEDVQSPNGSVYTWREAFNETNQAIQTISRFMECVNLNKLEPIPTEVRLINKSMELLDERKFWAGIVFTGITPDSVELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTGSEKKTGVYVQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKSIVYEKEARLKETMRIMGLDNGILWFSWFVSSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAMVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFSIKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTAVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEEIDEKSHPGSSQKGVSEICMEEEPTHLRLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSSIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPPSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSCLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQSCLHPFTEDDAVDPNDSDIDPESRETDLLSGMDGKGSYQLKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDMGTQELLNALTKDPGFGTRCMEGNPIPDTPCLAGEEDWTISPVPQSIVDLFQNGNWTMKNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQKTADILQNLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNSQALPPSHEVNDAIKQMKKLLKLTKDSSADRFLSSLGRFMAGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSQYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTNNKLNDINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVKAKLPPLNDEDEDVRRERQRILDGGGQNDILEIKELTKIYRRKRKPAVDRICIGIPPGECFGLLGVNGAGKSTTFKMLTGDTPVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYASNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSIVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQEFFGLAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDLSLHKNQTVVDVAVLTSFLQDEKVKESYV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	S-palmitoylation	-----MACWPQLRLL -----CCHHHHHHHH	9.19	-
14	N-linked_Glycosylation	LRLLLWKNLTFRRRQ HHHHHHHCCHHHCHH	32.50	-
23	S-palmitoylation	TFRRRQTCQLLLEVA HHHCHHHHHHHHHHH	1.71	-
98	N-linked_Glycosylation	PGVVGNFNKSIVSRL CCCCCCCCHHHHHHH	40.96	-
107	Phosphorylation	SIVSRLFSDAQRLLL HHHHHHCCHHHHHHH	36.31	30482847
151	N-linked_Glycosylation	LQDFLVDNETFSGFL HHHEECCCCCHHHHH	42.61	-
161	N-linked_Glycosylation	FSGFLQHNLSLPRST HHHHHHHCCCCCHHH	20.54	-
196	N-linked_Glycosylation	LHLASLCNGSKLEEI HHHHHHCCCCCHHHH	64.17	-
244	N-linked_Glycosylation	KPVVTKLNSTSHLPT HHHHHHCCCCCCCCH	44.81	-
292	N-linked_Glycosylation	VMFLTNVNSSSSSTQ HHHHCCCCCCCCHHH	37.94	-
337	N-linked_Glycosylation	YKALFGGNNTEEDVD EEECCCCCCCHHHHH	53.26	-
349	N-linked_Glycosylation	DVDTFYDNSTTPYCN HHHHHCCCCCCHHHH	29.85	-
400	N-linked_Glycosylation	RQVMAEVNKTFQELA HHHHHHHHHHHHHHH	29.20	-
478	N-linked_Glycosylation	PEDVQSPNGSVYTWR HHHCCCCCCCEEEHH	61.69	-
489	N-linked_Glycosylation	YTWREAFNETNQAIQ EEHHHHHHHHHHHHH	63.33	19349973
521	N-linked_Glycosylation	PTEVRLINKSMELLD CHHHHHHHHHHHHHH	34.63	-
637	Phosphorylation	DIFLRVMSRSMPLFM HHHHHHHHCCCCHHH	20.53	25777480
639	Phosphorylation	FLRVMSRSMPLFMTL HHHHHHCCCCHHHHH	19.90	25777480
645	Phosphorylation	RSMPLFMTLAWIYSV CCCCHHHHHHHHHHH	13.14	25777480
650	Phosphorylation	FMTLAWIYSVAVIIK HHHHHHHHHHHHHHH	6.08	25777480
651	Phosphorylation	MTLAWIYSVAVIIKS HHHHHHHHHHHHHHH	8.41	25777480
820	N-linked_Glycosylation	PVEEDGFNLTTAVSM CCCCCCCCHHHHHHH	41.84	-
1042	Phosphorylation	GGMQRKLSVALAFVG HHHHHHHHHHEEECC	14.37	-
1110	S-palmitoylation	IISHGKLCCVGSSLF EEECCCEEEECCCEE	1.69	-
1111	S-palmitoylation	ISHGKLCCVGSSLFL EECCCEEEECCCEEE	5.87	-
1137	Phosphorylation	LVKKDVESSLSSCRN EEECHHHHHHHHHCC	36.11	22324799
1138	Phosphorylation	VKKDVESSLSSCRNS EECHHHHHHHHHCCC	20.82	22324799
1140	Phosphorylation	KDVESSLSSCRNSSS CHHHHHHHHHCCCCC	29.37	22324799
1141	Phosphorylation	DVESSLSSCRNSSST HHHHHHHHHCCCCCC	23.53	22324799
1144	N-linked_Glycosylation	SSLSSCRNSSSTVSC HHHHHHCCCCCCCEE	51.04	-
1145	Phosphorylation	SLSSCRNSSSTVSCL HHHHHCCCCCCCEEE	13.30	27818261
1146	Phosphorylation	LSSCRNSSSTVSCLK HHHHCCCCCCCEEEE	33.31	9413861
1147	Phosphorylation	SSCRNSSSTVSCLKK HHHCCCCCCCEEEEH	32.42	22324799
1148	Phosphorylation	SCRNSSSTVSCLKKE HHCCCCCCCEEEEHH	20.56	22324799
1150	Phosphorylation	RNSSSTVSCLKKEDS CCCCCCCEEEEHHCC	17.51	23984901
1153	Ubiquitination	SSTVSCLKKEDSVSQ CCCCEEEEHHCCCCC	59.45	22790023
1255	Phosphorylation	FLKVAEESGVDAETS HHHHHHHHCCCCCCC	35.30	30635358
1261	Phosphorylation	ESGVDAETSDGTLPA HHCCCCCCCCCCCCC	33.56	30635358
1262	Phosphorylation	SGVDAETSDGTLPAR HCCCCCCCCCCCCCH	26.08	30635358
1265	Phosphorylation	DAETSDGTLPARRNR CCCCCCCCCCCHHCC	34.26	357209963
1281	S-palmitoylation	AFGDKQSCLHPFTED HHCCCCCCCCCCCCC	3.61	28680068
1286	Phosphorylation	QSCLHPFTEDDAVDP CCCCCCCCCCCCCCC	42.85	25159016
1294	N-linked_Glycosylation	EDDAVDPNDSDIDPE CCCCCCCCCCCCCHH	57.88	-
1296	Phosphorylation	DAVDPNDSDIDPESR CCCCCCCCCCCHHHC	43.01	21082442
1302	Phosphorylation	DSDIDPESRETDLLS CCCCCHHHCHHCCCC	40.58	23984901
1305	Phosphorylation	IDPESRETDLLSGMD CCHHHCHHCCCCCCC	30.73	22817900
1309	Phosphorylation	SRETDLLSGMDGKGS HCHHCCCCCCCCCCC	39.09	23984901
1314	Ubiquitination	LLSGMDGKGSYQLKG CCCCCCCCCCCCCCC	40.18	22790023
1453	N-linked_Glycosylation	VDLFQNGNWTMKNPS HHHHHCCCCCCCCCC	38.30	-
1499	N-linked_Glycosylation	KTADILQNLTGRNIS HHHHHHHHHCCCCHH	35.80	-
1504	N-linked_Glycosylation	LQNLTGRNISDYLVK HHHHCCCCHHHHHHH	39.19	-
1560	Acetylation	DAIKQMKKLLKLTKD HHHHHHHHHHHHCCC	54.43	23576753
1637	N-linked_Glycosylation	TAFNHPLNLTKQQLS EECCCCCCCCHHHHH	50.55	-
1824	Ubiquitination	RGLIDMVKNQAMADA CHHHHHHHHHHHHHH	36.38	22790023
1884	Ubiquitination	RPRPVKAKLPPLNDE CCCCCCCCCCCCCCC	56.67	22790023
1915	Ubiquitination	QNDILEIKELTKIYR CCCHHHHHHHHHHHH	36.98	22790023
1957	Ubiquitination	AGKSTTFKMLTGDTP CCCCEEEEHHCCCCC	30.79	22790023
2023	Ubiquitination	VPEKEVGKVGEWAIR CCHHHCCCHHHHHHH	52.85	22790023
2036	Ubiquitination	IRKLGLVKYGEKYAS HHHHCCCCCCHHCCC	53.21	22790023
2037	Phosphorylation	RKLGLVKYGEKYASN HHHCCCCCCHHCCCC	24.04	20116462
2040	Ubiquitination	GLVKYGEKYASNYSG CCCCCCHHCCCCCCC	41.58	22790023
2041	Phosphorylation	LVKYGEKYASNYSGG CCCCCHHCCCCCCCC	15.80	20116462
2044	N-linked_Glycosylation	YGEKYASNYSGGNKR CCHHCCCCCCCCCHH	27.15	-
2054	Phosphorylation	GGNKRKLSTAMALIG CCCHHHHHHHHHHHC	19.70	-
2078	Ubiquitination	PTTGMDPKARRFLWN CCCCCCHHHHHHHHH	50.70	22790023
2127	Phosphorylation	GRFRCLGSVQHLKNR CEEEEHHCHHHHHHH	12.98	28059163
2139	Phosphorylation	KNRFGDGYTIVVRIA HHHHCCCEEEEEEEE	9.68	25263469
2140	Phosphorylation	NRFGDGYTIVVRIAG HHHCCCEEEEEEEEC	16.90	25263469
2178	Phosphorylation	KHRNMLQYQLPSSLS HHHHHHHHCCCHHHH	14.19	28576409
2231	Ubiquitination	QSDDDHLKDLSLHKN CCCCCHHHHHHHCCC	53.88	22790023
2234	Phosphorylation	DDHLKDLSLHKNQTV CCHHHHHHHCCCCCH	38.26	25159016
2238	N-linked_Glycosylation	KDLSLHKNQTVVDVA HHHHHCCCCCHHHHH	31.82	-
2240	Phosphorylation	LSLHKNQTVVDVAVL HHHCCCCCHHHHHHH	31.71	23140645
2248	Phosphorylation	VVDVAVLTSFLQDEK HHHHHHHHHHHCCHH	15.72	23140645
2249	Phosphorylation	VDVAVLTSFLQDEKV HHHHHHHHHHCCHHH	21.57	23140645

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1042	S	Phosphorylation	Kinase	PKA	-	Uniprot
2054	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
2054	S	Phosphorylation		-
Phosphorylation on Ser-2054 regulates phospholipid efflux.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ABCA1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SPTC1_MOUSE	Sptlc1	physical	18484747

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ABCA1_MOUSE

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."; Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.; Nat. Biotechnol. 27:378-386(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-489, AND MASSSPECTROMETRY.	19349973 [Abstract]
Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1141 AND SER-1147, ANDMASS SPECTROMETRY.	17242355 [Abstract]

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