HAT1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HAT1_MOUSE
• UniProt AC: Q8BY71
• Protein Name: Histone acetyltransferase type B catalytic subunit
• Gene Name: Hat1
• Organism: Mus musculus (Mouse).
• Sequence Length: 416
• Subcellular Localization: Nucleus matrix.
• Protein Description: Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes..
• Protein Sequence: MAALEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDDETAFGYKGLKILLYYIAGSLSTLFRVEYSSKVDENFDCVEADDVEGKIRQIIPPGFCTNTNDFLSLLEKETNFKPFGTLLHTYTVPSQTGGETFTFQIHKADMTCRGFREYHERLQTFLMWFIETASFIDVDDERWHYFLVFEKYNKDGATLFATVGYMTVYNYYVYPDKTRPRVSQMLILTPFQGQGHGAQLLETVHRYYISFPTVLDITAEDPSRSYLKLRDFVLVKFCQFLPSFSRERLLQGFSEDMAIQAQQMFKINKQHARRVYEILRLLVTDMSDAEQYRSYRLDIKRRLISPYKKKQRDLAKMKKCLRPEELTNQMNQIEISVQHEQLEERFQELVEDYRRVIERLAQE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAALEKFLV ------CCHHHHHHH	22.28	23806337
6	Acetylation	--MAALEKFLVEYKS --CCHHHHHHHHHHH	44.86	23806337
12	Acetylation	EKFLVEYKSAVEKKL HHHHHHHHHHHHHHH	20.59	23806337
12	Ubiquitination	EKFLVEYKSAVEKKL HHHHHHHHHHHHHHH	20.59	-
23	Ubiquitination	EKKLAEYKCNTNTAI HHHHHHCCCCCCCCE	16.71	-
24	S-nitrosocysteine	KKLAEYKCNTNTAIE HHHHHCCCCCCCCEE	8.11	-
24	S-nitrosylation	KKLAEYKCNTNTAIE HHHHHCCCCCCCCEE	8.11	20925432
107	Ubiquitination	EADDVEGKIRQIIPP ECCCCCCCEEECCCC	22.62	-
187	Phosphorylation	MWFIETASFIDVDDE HHHHHHCCEECCCCC	30.10	-
222	Phosphorylation	TVGYMTVYNYYVYPD EEEEEEEEEEEECCC	6.57	-
225	Phosphorylation	YMTVYNYYVYPDKTR EEEEEEEEECCCCCC	7.00	-
227	Phosphorylation	TVYNYYVYPDKTRPR EEEEEEECCCCCCCC	6.92	-
340	Phosphorylation	RLLVTDMSDAEQYRS HHHHCCCCHHHHHHH	36.16	-
358	Phosphorylation	DIKRRLISPYKKKQR HHHHHHCCCCHHHHH	27.11	22942356
360	Phosphorylation	KRRLISPYKKKQRDL HHHHCCCCHHHHHHH	28.75	25777480

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HAT1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
187	S	Phosphorylation	Phosphorylated by AMPK at Ser-187; phosphorylation increases HAT1 activity.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HAT1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of HAT1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.