PUR4_MOUSE - dbPTM
PUR4_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PUR4_MOUSE
UniProt AC Q5SUR0
Protein Name Phosphoribosylformylglycinamidine synthase
Gene Name Pfas
Organism Mus musculus (Mouse).
Sequence Length 1337
Subcellular Localization Cytoplasm.
Protein Description Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity)..
Protein Sequence MAPVLHFYVRPSGHEGAASGRVFRRLQEKLPTLQSVETELCYNVHWAAETLPWAEEMKKLMWLFGCPLVRDDVAQEPWLVPGSNDLLLEVGPRLNFSTPASTNIVSVCQAAGLRAVDRVETTRRYRLSFTDHPTAEMEAISLAALHDRMTEQHYPDPIQSFSPQSIPAPLKGSIDILAEGRPALEKANQELGLALDSWDLDFYTKRFQELQRNPSTVEVFDLAQSNSEHSRHWFFKGQLHVDGKKLAHSLFESIMSTQASSNPNNVLKFCDNSSAIQGKKVKFLRPEDSTRPSCFQQQQGLRHVVFTAETHNFPTGVAPFSGATTGTGGRIRDVQCTGRGAHVVAGTAGYCFGNLHIPDYNLPWEDPSFQYPGNFARPLEVAIEASNGASDYGNKFGEPVLAGFARSLGLQLPDGQRREWIKPIMFSGGIGSMEAKHVGKKPPEPGMEVVKVGGPVYRIGVGGGAASSVQVQGDNTSDLDFGAVQRGDPEMEQKMNRVIRACVEAPGGNPICSLHDQGAGGNGNVLKELSDPEGAIIYTSRFQLGDPTLNALEIWGAEYQESNALLLRPSDRDFLSRASARERCPACFVGTITGDKRIVLVDDRECLVGKTGQGDAPLTPPTPVDLDLDWVLGKMPQKEFFLQRKPPVLQPLALPPELSVRQALNRVLRLPAVASKRYLTNKVDRSVGGLVAQQQCVGPLQTPLADVAVVALSHQECIGAATALGEQPVKSLLDPKAAARLAVSEALTNLVFALVTDLRDVKCSGNWMWAAKLPGEGAALADACEAMVAVMAALGVAVDGGKDSLSMAARVGTETVQAPGSLVISAYAVCPDITATVTPDLKHPGGKGHLLYVPLSPGQHRLGGTALAQCFSQLGEHPPDLDLPENLVRAFHITQGLLKECRLCSGHDVSDGGLVTCLLEMAFAGNCGIEVDVPAPGIHALPVLFAEEPGLVLEVQEADVAGVRQRYESAGLRCLELGHTGEAGPQAMARISVNKAVVVEEPVGELRALWEETSFQLDLLQAEPRCVIEEKQGLKERTGPSYYLPPTFPVASVPCKPGGPVPRVAILREEGSNGDREMADAFHLAGFEVWDVTMQDLCSGAIRLDTFRGVAFVGGFSYADVLGSAKGWAAAVTFNPQAREELGRFRRRPDTFSLGVCNGCQLLALLGWVGSDPSEEQAEPGQDSQPTQPGLLLRHNLSGRFESRWATVRVEPGPALMLRGMEGSVLPVWSAHGEGYMAFSSPELQAKIEAKGLVPLHWADDDGNPTEQYPLNPNGSPGGIAGICSQDGRHLALMPHPERAVRLWQWAWRPSPFDVLPTSPWLQLFINARNWTQEDSC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
108GlutathionylationSTNIVSVCQAAGLRA
CCCHHHHHHHCCCCC		1.4524333276
150PhosphorylationAALHDRMTEQHYPDP
HHHHHHHHHHCCCCC		33.1328285833
154PhosphorylationDRMTEQHYPDPIQSF
HHHHHHCCCCCCHHC		14.7123984901
160PhosphorylationHYPDPIQSFSPQSIP
CCCCCCHHCCCCCCC		28.5423984901
162PhosphorylationPDPIQSFSPQSIPAP
CCCCHHCCCCCCCCC		27.5526643407
165PhosphorylationIQSFSPQSIPAPLKG
CHHCCCCCCCCCCCC		33.6426643407
215PhosphorylationQELQRNPSTVEVFDL
HHHHHCCCCEEEEEH		48.9422817900
216PhosphorylationELQRNPSTVEVFDLA
HHHHCCCCEEEEEHH		23.1818846507
270GlutathionylationPNNVLKFCDNSSAIQ
CCCCEEECCCCHHHC		4.6524333276
279UbiquitinationNSSAIQGKKVKFLRP
CCHHHCCCEEEECCC		37.7122790023
294GlutathionylationEDSTRPSCFQQQQGL
CCCCCCCHHHHHCCC		3.8524333276
436UbiquitinationGIGSMEAKHVGKKPP
CCCCCCHHCCCCCCC		26.0522790023
494AcetylationGDPEMEQKMNRVIRA
CCHHHHHHHHHHHHH		25.4922826441
512GlutathionylationAPGGNPICSLHDQGA
CCCCCCCCCCCCCCC		3.6024333276
538PhosphorylationDPEGAIIYTSRFQLG
CCCCCEEEEEECCCC		7.7922817900
584GlutathionylationRASARERCPACFVGT
HHHHHHHCCCCEEEE		1.8324333276
587GlutathionylationARERCPACFVGTITG
HHHHCCCCEEEEECC		1.3924333276
606GlutathionylationVLVDDRECLVGKTGQ
EEECCCCEECCCCCC		3.7724333276
611PhosphorylationRECLVGKTGQGDAPL
CCEECCCCCCCCCCC		28.8926745281
619PhosphorylationGQGDAPLTPPTPVDL
CCCCCCCCCCCCCCC		26.6026824392
622PhosphorylationDAPLTPPTPVDLDLD
CCCCCCCCCCCCCHH		36.8326745281
638AcetylationVLGKMPQKEFFLQRK
HCCCCCCHHHHHCCC		51.0922826441
804PhosphorylationAVDGGKDSLSMAARV
CCCCCHHHHHHHHHH		26.3221930439
806PhosphorylationDGGKDSLSMAARVGT
CCCHHHHHHHHHHCC		15.4421930439
813PhosphorylationSMAARVGTETVQAPG
HHHHHHCCCEEECCC		26.1426160508
815PhosphorylationAARVGTETVQAPGSL
HHHHCCCEEECCCCE		20.1126160508
821PhosphorylationETVQAPGSLVISAYA
CEEECCCCEEEEEEE		20.5726160508
825PhosphorylationAPGSLVISAYAVCPD
CCCCEEEEEEEECCC		14.0326160508
827PhosphorylationGSLVISAYAVCPDIT
CCEEEEEEEECCCCE		7.8726160508
834PhosphorylationYAVCPDITATVTPDL
EEECCCCEEEECCCC		24.5326160508
836PhosphorylationVCPDITATVTPDLKH
ECCCCEEEECCCCCC		19.0926160508
838PhosphorylationPDITATVTPDLKHPG
CCCEEEECCCCCCCC		13.5126160508
1031UbiquitinationPRCVIEEKQGLKERT
CCEEEEECCCCCCCC		36.5522790023
1055GlutathionylationFPVASVPCKPGGPVP
CCCCCCCCCCCCCCC		8.5524333276
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PUR4_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PUR4_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PUR4_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PUR4_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PUR4_MOUSE

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Related Literatures of Post-Translational Modification

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