TRAF4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRAF4_MOUSE
• UniProt AC: Q61382
• Protein Name: TNF receptor-associated factor 4
• Gene Name: Traf4
• Organism: Mus musculus (Mouse).
• Sequence Length: 470
• Subcellular Localization: Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
• Protein Description: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions (By similarity). Required for normal skeleton development, and for normal development of the respiratory tract..
• Protein Sequence: MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAKIYPDPELEVQVLGLAIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVVPCPNRCPAKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGVCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCAYCTKEFVYDTIQSHQYQCPRLPVPCPNQCGVGTVAREDLPTHLKDSCSTAFVLCPFKESGCKHRCPKLAMGRHVEESVKPHLAMMCALVSRQRQELQELRRELEELSIGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSIYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKRNYVRDDAVFIRASVELPRKILS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
65	Ubiquitination	QLPLDYAKIYPDPEL HCCCCHHHHCCCCHH	36.22	-
166	Phosphorylation	VCPQESVYCENKCGA CCCCCCHHCCCHHHH	11.88	-
170	Ubiquitination	ESVYCENKCGARMMR CCHHCCCHHHHHHHH	16.26	-
190	Ubiquitination	HATSECPKRTQPCAY HCCCCCCCCCCCCCC	78.66	-
204	Phosphorylation	YCTKEFVYDTIQSHQ CCCCHHHHHHHHHHC	16.82	26032504
422	Phosphorylation	KNFQKPGTWRGSLDE CCCCCCCCCCCCCCH	22.10	23984901
426	Phosphorylation	KPGTWRGSLDESSLG CCCCCCCCCCHHHCC	24.87	26824392
430	Phosphorylation	WRGSLDESSLGFGYP CCCCCCHHHCCCCCC	30.45	26643407
431	Phosphorylation	RGSLDESSLGFGYPK CCCCCHHHCCCCCCC	30.39	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRAF4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRAF4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRAF4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FHL2_MOUSE	Fhl2	physical	16184196

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.