dbPTM

ACATN_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ACATN_MOUSE
UniProt AC	Q99J27
Protein Name	Acetyl-coenzyme A transporter 1
Gene Name	Slc33a1
Organism	Mus musculus (Mouse).
Sequence Length	550
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein .
Protein Description	Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides. [PubMed: 10570973 Negatively regulates BMP signaling (By similarity]
Protein Sequence	MSPTISHKDSSRQRRSGMFSHALDMKSGPLPPGGWDDSRRDSVGGEGDREVLLGDAGPGDLPKAPRSYRSELSSILLLLFLYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFSLKLLWAPLVDAVYFKNFGRRKSWLVPTQYTLGIFMIYLSTQVDRLLGNIDGRTPDVVALTVTFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADFCNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENREASIVKEETQGITDTYKLLFSIIKMPAVLAFCLLILTSKIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILPLLISKYTAGPQPLNIFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFPLYYYIIVLLSYALHQVTLYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECVGASNQNCRTPDAIELCKKLGGSCVTALDGYYVESIICVLIGFGWWFFLGPKFKKLQDEGPSSWKCKRNN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSPTISHKD ------CCCCCCCCC	30.65	25777480
4	Phosphorylation	----MSPTISHKDSS ----CCCCCCCCCCH	28.01	25777480
6	Phosphorylation	--MSPTISHKDSSRQ --CCCCCCCCCCHHH	27.28	25777480
10	Phosphorylation	PTISHKDSSRQRRSG CCCCCCCCHHHHHCC	32.02	25777480
11	Phosphorylation	TISHKDSSRQRRSGM CCCCCCCHHHHHCCC	42.43	25777480
16	Phosphorylation	DSSRQRRSGMFSHAL CCHHHHHCCCHHHHH	36.48	25521595
20	Phosphorylation	QRRSGMFSHALDMKS HHHCCCHHHHHCCCC	10.04	25521595
38	Phosphorylation	PPGGWDDSRRDSVGG CCCCCCCCCCCCCCC	27.09	23140645
42	Phosphorylation	WDDSRRDSVGGEGDR CCCCCCCCCCCCCCC	22.35	25521595
103	N-linked_Glycosylation	PLILQSKNVSYTDQA HEEEECCCCCCCCHH	32.96	-
160	Phosphorylation	IFMIYLSTQVDRLLG HHHHHHHHHHHHHHC	29.98	21183079
320	Phosphorylation	AFCLLILTSKIGFSA HHHHHHHHHCCCCCH	22.45	-
321	Phosphorylation	FCLLILTSKIGFSAA HHHHHHHHCCCCCHH	20.87	-
497	S-palmitoylation	TPDAIELCKKLGGSC CHHHHHHHHHHCCCH	2.07	28526873

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ACATN_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ACATN_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ACATN_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ACATN_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ACATN_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Mitochondrial phosphoproteome revealed by an improved IMAC method andMS/MS/MS."; Lee J., Xu Y., Chen Y., Sprung R., Kim S.C., Xie S., Zhao Y.; Mol. Cell. Proteomics 6:669-676(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, AND MASSSPECTROMETRY.	17208939 [Abstract]