CO8G_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CO8G_MOUSE
• UniProt AC: Q8VCG4
• Protein Name: Complement component C8 gamma chain
• Gene Name: C8g
• Organism: Mus musculus (Mouse).
• Sequence Length: 202
• Subcellular Localization: Secreted.
• Protein Description: C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol (By similarity)..
• Protein Sequence: MLSPGAVLFFTLLLTASSLGQRTRKPIGSTSPISTIQAQVNFSAQKFAGTWLLVAVGSSCRFLQEQGHRAEATTLHAAPQGAAMAVSTFRKLDGICWQVRQLFENTGVPGRFLFQVSRARGPVHMVVAETDYQSFAILYLEQGRKLSVKLYVRSLPVNDSVLDVFERRVREANLTEDQILFFPKYGFCETADQLHILNEVPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	PGAVLFFTLLLTASS HHHHHHHHHHHHHHH	14.79	-
21	Pyrrolidone_carboxylic_acid	LTASSLGQRTRKPIG HHHHHCCCCCCCCCC	49.19	-
21	Pyrrolidone_carboxylic_acid	LTASSLGQRTRKPIG HHHHHCCCCCCCCCC	49.19	-
41	N-linked_Glycosylation	STIQAQVNFSAQKFA CEEEEEECCCHHHHC	17.05	-
145	Malonylation	LYLEQGRKLSVKLYV EEECCCCEEEEEEEE	52.52	26073543
149	Malonylation	QGRKLSVKLYVRSLP CCCEEEEEEEEEECC	30.63	26073543
158	N-linked_Glycosylation	YVRSLPVNDSVLDVF EEEECCCCHHHHHHH	33.62	16944957
173	N-linked_Glycosylation	ERRVREANLTEDQIL HHHHHHCCCCCCEEE	42.62	16944957

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CO8G_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CO8G_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CO8G_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CO8G_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Proteome-wide characterization of N-glycosylation events by diagonalchromatography.";
Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J.,Gevaert K.;
J. Proteome Res. 5:2438-2447(2006).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-158 AND ASN-173, AND MASSSPECTROMETRY.
PubMed: 16944957