SRPK3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRPK3_MOUSE
• UniProt AC: Q9Z0G2
• Protein Name: SRSF protein kinase 3
• Gene Name: Srpk3
• Organism: Mus musculus (Mouse).
• Sequence Length: 565
• Protein Description: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development..
• Protein Sequence: MSANAGGSGSVDCGGSSSSSQTSCGPESSGSELTPATPAPRLLQGLLGSDDEEQEDPKDYCKGGYYPVKIGDLFNGRYHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGDAYIRRLAAEATEWQQSGAQPPSRSTVSTAPQEVLIGKLSKNKRKKMRRKRKQQKRLLEERLRDLQRLEAMEAAVQAEDSSSRLERGSGSTSSSGCHPEGTRAGPSPASSSPVPGGERSLSPSSQTSGFSGSLFSTASCSILSGSSNQRETGGLLSPSTPFGASNLLVNPLEPQNADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGELRHIPNLKHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPWLNP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	LLQGLLGSDDEEQED HHHHHHCCCCCCCCC	41.69	27742792
77	Methylation	IGDLFNGRYHVVRKL EHHHHCCEEEEEECC	21.35	30988161
82	Methylation	NGRYHVVRKLGWGHF CCEEEEEECCCCCCC	27.65	30988167
210	O-linked_Glycosylation	TKCKIIHTDIKPENI HCCEEECCCCCHHHE	29.07	30059200
302	Phosphorylation	AAVQAEDSSSRLERG HHHHCHHCCCCCCCC	23.01	28285833
328	Phosphorylation	EGTRAGPSPASSSPV CCCCCCCCCCCCCCC	31.98	24899341
331	Phosphorylation	RAGPSPASSSPVPGG CCCCCCCCCCCCCCC	34.43	24899341
332	Phosphorylation	AGPSPASSSPVPGGE CCCCCCCCCCCCCCC	40.54	23737553
333	Phosphorylation	GPSPASSSPVPGGER CCCCCCCCCCCCCCC	27.67	27742792
419	Phosphorylation	CWVHKHFTEDIQTRQ EEEEHHHCCCHHHCH	32.25	29233185
424	Phosphorylation	HFTEDIQTRQYRAVE HHCCCHHHCHHEEEE	21.77	23684622

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SRPK3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SRPK3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRPK3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SRPK3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.