| UniProt ID | PDK3_MOUSE | |
|---|---|---|
| UniProt AC | Q922H2 | |
| Protein Name | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial | |
| Gene Name | Pdk3 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 415 | |
| Subcellular Localization | Mitochondrion matrix. | |
| Protein Description | Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species (By similarity).. | |
| Protein Sequence | MRLFYRLLKQPVPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPRVLDNFLNVLINIRNRHNDVVPTMAQGVIEYKEKFGFDPFISSNIQYFLDRFYTNRISFRMLINQHTLLFGGDTNPAHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPNKPIQVVYVPSHLFHMLFELFKNSMRATVELHEDKKEGYPAVKTLVTLGKEDLSIKISDLGGGVPLRKIDRLFNYMYSTAPRPSLEPTRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKALSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYKAKQDKIKSNRTF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 211 | Phosphorylation | AKMLCEQYYLVAPEL HHHHHHHHHEECCCC | 4.04 | - | |
| 212 | Phosphorylation | KMLCEQYYLVAPELE HHHHHHHHEECCCCC | 8.39 | - | |
| 272 | Phosphorylation | EGYPAVKTLVTLGKE CCCCHHHHHHEECCC | 21.62 | 29109428 | |
| 278 | Succinylation | KTLVTLGKEDLSIKI HHHHEECCCCCEEEH | 51.68 | - | |
| 278 | Acetylation | KTLVTLGKEDLSIKI HHHHEECCCCCEEEH | 51.68 | 23806337 | |
| 278 | Succinylation | KTLVTLGKEDLSIKI HHHHEECCCCCEEEH | 51.68 | 23806337 | |
| 282 | Phosphorylation | TLGKEDLSIKISDLG EECCCCCEEEHHHCC | 33.87 | 23737553 | |
| 374 | Succinylation | ERLPVFNKSAWRHYK HCCCCCCHHHHHHCC | 30.04 | - | |
| 390 | Phosphorylation | TPEADDWSNPSSEPR CCCCCCCCCCCCCCC | 45.95 | 26643407 | |
| 393 | Phosphorylation | ADDWSNPSSEPRDAS CCCCCCCCCCCCCHH | 52.13 | 26643407 | |
| 394 | Phosphorylation | DDWSNPSSEPRDASK CCCCCCCCCCCCHHH | 53.53 | 26643407 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PDK3_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PDK3_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PDK3_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PDK3_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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