PTPRS_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTPRS_MOUSE
• UniProt AC: B0V2N1
• Protein Name: Receptor-type tyrosine-protein phosphatase S
• Gene Name: Ptprs
• Organism: Mus musculus (Mouse).
• Sequence Length: 1907
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Cell projection, axon . Perikaryon . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane . Cell junction, synapse, synaptosome . Cell junction, synapse, postsynaptic cell membrane, postsy
• Protein Description: Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. [PubMed: 19833921]
• Protein Sequence: MAPTWSPSVVSVVGPVGLFLVLLARGCLAEEPPRFIREPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIDFDESSGAVLRIQPLRTPRDENVYECVAQNSVGEITIHAKLTVLREDQLPPGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPVVTENTATSITVTWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEAKSETSIGLSWSAPRQESVIKYELLFREGDRGREVGRTFDPTTAFVVEDLKPNTEYAFRLAARSPQGLGAFTAVVRQRTLQAKPSAPPQDVKCTSLRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPDPKEVNNIPPTTTQILLEALEKWTEYRVTAVAYTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPTPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDIMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPADAAEDPVLGYRLQFGREDAAPATLELAAWERRFAAPAHKGATYVFRLAARGRAGLGEEAAAALSIPEDAPRGFPQILGAAGNVSAGSVLLRWLPPVPAERNGAIIKYTVSVREAGAPGPATETELAAAAQPGAETALTLRGLRPETAYELRVRAHTRRGPGPFSPPLRYRLARDPVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTARTAFNMLSGKPSVAPKPDNDGFIVVYLPDGQSPVTVQNYFIVMVPLRKSRGGQFPVLLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSILPAVFHPGNQKQYGGFDNRGLEPGHRYVLFVLAVLQKNEPTFAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPITDMAEHMERLKANDSLKLSQEYESIDPGQQFTWEHSNLEANKPKNRYANVIAYDHSRVILQPLEGIMGSDYINANYVDGYRRQNAYIATQGPLPETFGDFWRMVWEQRSATVVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTMELATFCVRTFSLHKNGSSEKREVRHFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKTEKTVDVYGHVTLMRSQRNYMVQTEDQYGFIHEALLEAVGCGNTEVPARSLYTYIQKLAQVEPGEHVTGMELEFKRLASSKAHTSRFITASLPCNKFKNRLVNILPYESSRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRALWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGAPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKVLRTQRPAMVQTEDEYQFCFQAALEYLGSFDHYAT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
205	Phosphorylation	EETDQGKYECVATNS CCCCCCEEEEEEECC	22.76	28978645
210	Phosphorylation	GKYECVATNSAGVRY CEEEEEEECCCCCCC	14.87	28978645
212	Phosphorylation	YECVATNSAGVRYSS EEEEEECCCCCCCCC	23.26	28978645
250	N-linked_Glycosylation	IMPGGNVNITCVAVG CCCCCCEEEEEEECC	28.05	-
295	N-linked_Glycosylation	TDVKDSANYTCVAMS CCCCCCCCCEEEEEC	36.28	-
527	Phosphorylation	AEAKSETSIGLSWSA EEECCCCCCCCCCCC	15.59	-
531	Phosphorylation	SETSIGLSWSAPRQE CCCCCCCCCCCCCCH	17.48	-
533	Phosphorylation	TSIGLSWSAPRQESV CCCCCCCCCCCCHHE	25.64	-
720	N-linked_Glycosylation	KVEAEALNATAIRVL CHHHHHHCCCEEEHH	42.15	-
857	Phosphorylation	REDAAPATLELAAWE CCCCCCHHHHHHHHH	21.50	22006019
916	N-linked_Glycosylation	QILGAAGNVSAGSVL HHHCCCCCCCCCCHH	21.61	-
1004	Methylation	FSPPLRYRLARDPVS CCCCHHHHHCCCCCC	18.55	30988959
1297	Ubiquitination	KDSEPRTKCLLNNAD CCCCCCHHHHHCCCC	24.94	22790023
1376	Ubiquitination	HSNLEANKPKNRYAN CCCCCCCCCCCCCCC	65.50	22790023
1381	Phosphorylation	ANKPKNRYANVIAYD CCCCCCCCCCEEEEC	16.36	29899451
1621	Phosphorylation	EVPARSLYTYIQKLA CCCHHHHHHHHHHHC	9.95	29514104
1644	Ubiquitination	TGMELEFKRLASSKA CCCEEEHHHHHCCCC	36.81	22790023
1810	Ubiquitination	WPEQGAPKSGEGFID CCCCCCCCCCCCHHH	71.24	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTPRS_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTPRS_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTPRS_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PTPRS_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.