TFAM_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TFAM_MOUSE
• UniProt AC: P40630
• Protein Name: Transcription factor A, mitochondrial
• Gene Name: Tfam
• Organism: Mus musculus (Mouse).
• Sequence Length: 243
• Subcellular Localization: Isoform Mitochondrial: Mitochondrion . Mitochondrion matrix, mitochondrion nucleoid .; Isoform Nuclear: Nucleus.
• Protein Description: Isoform Mitochondrial binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA. Isoform Nuclear may also function as a transcriptional activator or may have a structural role in the compaction of nuclear DNA during spermatogenesis..
• Protein Sequence: MALFRGMWSVLKALGRTGVEMCAGCGGRIPSSISLVCIPKCFSSMGSYPKKPMSSYLRFSTEQLPKFKAKHPDAKLSELVRKIAALWRELPEAEKKVYEADFKAEWKAYKEAVSKYKEQLTPSQLMGMEKEARQRRLKKKALVKRRELILLGKPKRPRSAYNIYVSESFQEAKDDSAQGKLKLVNEAWKNLSPEEKQAYIQLAKDDRIRYDNEMKSWEEQMAEVGRSDLIRRSVKRSGDISEH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	ALFRGMWSVLKALGR HHHHHHHHHHHHHHC	14.53	21149613
31	Phosphorylation	GCGGRIPSSISLVCI CCCCCCCCCCEEEEE	37.62	25293948
32	Phosphorylation	CGGRIPSSISLVCIP CCCCCCCCCEEEEEH	15.73	25293948
34	Phosphorylation	GRIPSSISLVCIPKC CCCCCCCEEEEEHHH	19.39	25293948
54	Phosphorylation	SYPKKPMSSYLRFST CCCCCCHHHHCCCCH	25.10	-
55	Phosphorylation	YPKKPMSSYLRFSTE CCCCCHHHHCCCCHH	23.18	-
60	Phosphorylation	MSSYLRFSTEQLPKF HHHHCCCCHHHCHHH	25.30	-
66	Succinylation	FSTEQLPKFKAKHPD CCHHHCHHHHHHCCC	69.00	23806337
66	Succinylation	FSTEQLPKFKAKHPD CCHHHCHHHHHHCCC	69.00	-
66	Acetylation	FSTEQLPKFKAKHPD CCHHHCHHHHHHCCC	69.00	23806337
70	Acetylation	QLPKFKAKHPDAKLS HCHHHHHHCCCHHHH	57.15	23864654
82	Acetylation	KLSELVRKIAALWRE HHHHHHHHHHHHHHH	29.26	24062335
82	Malonylation	KLSELVRKIAALWRE HHHHHHHHHHHHHHH	29.26	26320211
103	Acetylation	KVYEADFKAEWKAYK HHHHHHHHHHHHHHH	46.04	23201123
107	Acetylation	ADFKAEWKAYKEAVS HHHHHHHHHHHHHHH	33.09	23201123
110	Succinylation	KAEWKAYKEAVSKYK HHHHHHHHHHHHHHH	44.02	26388266
115	Acetylation	AYKEAVSKYKEQLTP HHHHHHHHHHHHCCH	54.46	23201123
117	Acetylation	KEAVSKYKEQLTPSQ HHHHHHHHHHCCHHH	42.60	23201123
121	Phosphorylation	SKYKEQLTPSQLMGM HHHHHHCCHHHHCCC	22.16	29472430
123	Phosphorylation	YKEQLTPSQLMGMEK HHHHCCHHHHCCCHH	30.61	25293948
130	Acetylation	SQLMGMEKEARQRRL HHHCCCHHHHHHHHH	48.02	23201123
159	Phosphorylation	GKPKRPRSAYNIYVS CCCCCCCCCCEEEEC	37.48	30635358
161	Phosphorylation	PKRPRSAYNIYVSES CCCCCCCCEEEECHH	11.88	30635358
192	Phosphorylation	NEAWKNLSPEEKQAY HHHHHHCCHHHHHHH	39.39	-
204	Acetylation	QAYIQLAKDDRIRYD HHHHHHHHCCCCCCH	69.61	23201123
210	Phosphorylation	AKDDRIRYDNEMKSW HHCCCCCCHHHCCCH	22.28	20469934
241	Phosphorylation	VKRSGDISEH----- HHHHCCCCCC-----	34.07	27087446

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
54	S	Phosphorylation	Kinase	PKA	-	Uniprot
55	S	Phosphorylation	Kinase	PKA	-	Uniprot
60	S	Phosphorylation	Kinase	PKA	-	Uniprot
159	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TFAM_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TFAM_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TFAM_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.