dbPTM

PYGM_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PYGM_MOUSE
UniProt AC	Q9WUB3
Protein Name	Glycogen phosphorylase, muscle form
Gene Name	Pygm
Organism	Mus musculus (Mouse).
Sequence Length	842
Subcellular Localization
Protein Description	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties..
Protein Sequence	MSRPLSDQDKRKQISVRGLAGVENVSELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGSRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRILVDLERLDWDKAWDVTVKTCAYTNHTVLPEALERWPVHLMETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEVIAERIGEDYISDLDQLRKLLSYVDDEAFIRDVAKVKQENKLKFSAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHIITLYNRIKREPNRFMVPRTIMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPAVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVERLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEEYIKCQDKVSELYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDEKI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSRPLSDQD ------CCCCCCHHH	42.48	-
2	Phosphorylation	------MSRPLSDQD ------CCCCCCHHH	42.48	27742792
6	Phosphorylation	--MSRPLSDQDKRKQ --CCCCCCHHHHHHC	35.59	19854140
10	Ubiquitination	RPLSDQDKRKQISVR CCCCHHHHHHCCCHH	56.73	22790023
15	Phosphorylation	QDKRKQISVRGLAGV HHHHHCCCHHHHHCC	11.85	22817900
26	Phosphorylation	LAGVENVSELKKNFN HHCCCCHHHHHHHHC	49.12	22210690
29	Ubiquitination	VENVSELKKNFNRHL CCCHHHHHHHHCCCE	41.44	22790023
29	Acetylation	VENVSELKKNFNRHL CCCHHHHHHHHCCCE	41.44	19863713
42	Ubiquitination	HLHFTLVKDRNVATP CEEEEEECCCCCCCC	54.83	22790023
76	Phosphorylation	IRTQQHYYEKDPKRI HHHCCHHHHCCCCCE	17.87	28464351
78	Ubiquitination	TQQHYYEKDPKRIYY HCCHHHHCCCCCEEE	64.31	27667366
143	S-nitrosylation	GLGRLAACFLDSMAT HHHHHHHHHHHHHHH	2.64	21278135
143	S-nitrosocysteine	GLGRLAACFLDSMAT HHHHHHHHHHHHHHH	2.64	-
156	Phosphorylation	ATLGLAAYGYGIRYE HHHHHHHHCCCCEEE	12.79	-
172	S-nitrosocysteine	GIFNQKICGGWQMEE EECCCEECCCCCCHH	5.48	-
172	S-nitrosylation	GIFNQKICGGWQMEE EECCCEECCCCCCHH	5.48	21278135
186	Phosphorylation	EADDWLRYGNPWEKA HHHCHHHCCCHHHHC	21.05	28542873
198	Phosphorylation	EKARPEFTLPVHFYG HHCCCCCEECEEEEE	28.61	28464351
204	Phosphorylation	FTLPVHFYGRVEHTS CEECEEEEEEEEECC	6.80	28542873
210	Phosphorylation	FYGRVEHTSQGAKWV EEEEEEECCCCCCEE	14.83	28464351
211	Phosphorylation	YGRVEHTSQGAKWVD EEEEEECCCCCCEEE	28.64	28542873
227	Phosphorylation	QVVLAMPYDTPVPGY EEEEECCCCCCCCCC	21.26	-
241	Phosphorylation	YRNNVVNTMRLWSAK CCCCCHHHHHHHCCC	7.64	28464351
248	Ubiquitination	TMRLWSAKAPNDFNL HHHHHCCCCCCCCCC	59.88	22790023
277	Phosphorylation	RNLAENISRVLYPND HHHHHHHHCCCCCCC	28.11	20531401
290	Ubiquitination	NDNFFEGKELRLKQE CCCCCCCCCCCCCCE	46.51	22790023
290	Acetylation	NDNFFEGKELRLKQE CCCCCCCCCCCCCCE	46.51	24588079
316	Ubiquitination	IRRFKSSKFGSRDPV HHHHHHCCCCCCCCC	61.92	22790023
325	Phosphorylation	GSRDPVRTNFDAFPD CCCCCCCCCCCCCCC	40.23	28464351
344	Phosphorylation	QLNDTHPSLAIPELM ECCCCCHHHHHHHHH	23.87	28542873
364	Succinylation	LERLDWDKAWDVTVK HHHCCHHHHCCEEEE	47.31	-
364	Ubiquitination	LERLDWDKAWDVTVK HHHCCHHHHCCEEEE	47.31	22790023
373	S-nitrosylation	WDVTVKTCAYTNHTV CCEEEEECCCCCCCC	1.95	21278135
373	S-nitrosocysteine	WDVTVKTCAYTNHTV CCEEEEECCCCCCCC	1.95	-
405	Phosphorylation	PRHLQIIYEINQRFL HHHHHHHHHHHHHHH	16.64	28464351
430	Phosphorylation	VDRLRRMSLVEEGAV HHHHHHHHHHHHCCC	27.70	27742792
446	S-nitrosylation	RINMAHLCIAGSHAV EEEHHHHHHHCHHHH	1.12	21278135
446	S-nitrosocysteine	RINMAHLCIAGSHAV EEEHHHHHHHCHHHH	1.12	-
461	Phosphorylation	NGVARIHSEILKKTI CCHHHHCHHHHHHHH	24.78	28542873
467	Phosphorylation	HSEILKKTIFKDFYE CHHHHHHHHCCCHHH	30.02	-
473	Phosphorylation	KTIFKDFYELEPHKF HHHCCCHHHCCCHHC	29.73	27742792
483	Ubiquitination	EPHKFQNKTNGITPR CCHHCCCCCCCCCCC	32.36	22790023
496	S-nitrosylation	PRRWLVLCNPGLAEV CCCEEEEECCCHHHH	4.50	21278135
496	S-nitrosocysteine	PRRWLVLCNPGLAEV CCCEEEEECCCHHHH	4.50	-
507	Methylation	LAEVIAERIGEDYIS HHHHHHHHHCCCHHC	32.94	58859215
514	Phosphorylation	RIGEDYISDLDQLRK HHCCCHHCCHHHHHH	26.37	28464351
521	Ubiquitination	SDLDQLRKLLSYVDD CCHHHHHHHHHHCCH	63.47	22790023
524	Phosphorylation	DQLRKLLSYVDDEAF HHHHHHHHHCCHHHH	33.28	22210690
562	Phosphorylation	KVHINPNSLFDVQVK EEECCCCCCHHHHHH	31.50	28542873
574	Phosphorylation	QVKRIHEYKRQLLNC HHHHHHHHHHHHHHH	9.41	29899451
575	Acetylation	VKRIHEYKRQLLNCL HHHHHHHHHHHHHHH	30.59	15618663
581	S-palmitoylation	YKRQLLNCLHIITLY HHHHHHHHHHHHHHH	2.70	26165157
614	Phosphorylation	GGKAAPGYHMAKMII CCCCCCCHHHHHHHH	6.33	22871156
618	Ubiquitination	APGYHMAKMIIKLIT CCCHHHHHHHHHHHH	24.05	22790023
656	Ubiquitination	YRVSLAEKVIPAADL CCHHHHHHHCCHHHH	39.60	22790023
681	N6-(pyridoxal phosphate)lysine	ASGTGNMKFMLNGAL CCCCCCCEEEECCEE	31.46	-
681	Other	ASGTGNMKFMLNGAL CCCCCCCEEEECCEE	31.46	-
732	Phosphorylation	RGYNAQEYYDRIPEL CCCCHHHHHHHHHHH	9.89	28542873
733	Phosphorylation	GYNAQEYYDRIPELR CCCHHHHHHHHHHHH	9.67	28464351
747	Phosphorylation	RQIIEQLSSGFFSPK HHHHHHHHCCCCCCC	28.27	28464351
748	Phosphorylation	QIIEQLSSGFFSPKQ HHHHHHHCCCCCCCC	48.49	-
754	Ubiquitination	SSGFFSPKQPDLFKD HCCCCCCCCCCHHHH	73.58	22790023
783	Ubiquitination	ADYEEYIKCQDKVSE CCHHHHHHCHHHHHH	25.58	22790023
784	S-nitrosocysteine	DYEEYIKCQDKVSEL CHHHHHHCHHHHHHH	4.61	-
784	S-nitrosylation	DYEEYIKCQDKVSEL CHHHHHHCHHHHHHH	4.61	21278135
809	Phosphorylation	VIRNIATSGKFSSDR HHHHHHHCCCCCCCH	30.85	28542873
811	Ubiquitination	RNIATSGKFSSDRTI HHHHHCCCCCCCHHH	41.67	22790023
813	Phosphorylation	IATSGKFSSDRTIAQ HHHCCCCCCCHHHHH	34.51	19854140
821	Phosphorylation	SDRTIAQYAREIWGV CCHHHHHHHHHHHCC	9.90	19854140
831	Phosphorylation	EIWGVEPSRQRLPAP HHHCCCCCCCCCCCC	27.78	28542873
841	Ubiquitination	RLPAPDEKI------ CCCCCCCCC------	62.18	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
15	S	Phosphorylation	Kinase	PHK	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
15	S	Phosphorylation		-
Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PYGM_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PYGM_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PYGM_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain."; Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.; J. Proteome Res. 7:311-318(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-473, AND MASSSPECTROMETRY.	18034455 [Abstract]

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