ACSL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACSL1_MOUSE
• UniProt AC: P41216
• Protein Name: Long-chain-fatty-acid--CoA ligase 1
• Gene Name: Acsl1
• Organism: Mus musculus (Mouse).
• Sequence Length: 699
• Subcellular Localization: Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane prote
• Protein Description: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses oleate, arachidonate, eicosapentaenoate and docosahexaenoate as substrates (By similarity)..
• Protein Sequence: MEVHELFRYFRMPELIDIRQYVRTLPTNTLMGFGAFAALTTFWYATRPKALKPPCDLSMQSVEIAGTTDGIRRSAVLEDDKLLVYYYDDVRTMYDGFQRGIQVSNNGPCLGSRKPNQPYEWISYKEVAELAECIGSGLIQKGFKPCSEQFIGLFSQNRPEWVIVEQGCFSYSMVVVPLYDTLGADAITYIVNKAELSVIFADKPEKAKLLLEGVENKLTPCLKIIVIMDSYGSDLVERGKKCGVEIISLKALEDLGRVNRVKPKPPEPEDLAIICFTSGTTGNPKGAMITHQNIINDCSGFIKATESAFIASTDDVLISFLPLAHMFETVVECVMLCHGAKIGFFQGDIRLLMDDLKVLQPTIFPVVPRLLNRMFDRIFGQANTSLKRWLLDFASKRKEAELRSGIVRNNSLWDKLIFHKIQSSLGGKVRLMITGAAPVSATVLTFLRTALGCQFYEGYGQTECTAGCCLSLPGDWTAGHVGAPMPCNYVKLVDVEEMNYLASKGEGEVCVKGANVFKGYLKDPARTAEALDKDGWLHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYLRSEAVAQVFVHGESLQAFLIAVVVPDVESLPSWAQKRGLQGSFEELCRNKDINKAILDDLLKLGKEAGLKPFEQVKGIAVHPELFSIDNGLLTPTLKAKRPELRNYFRSQIDELYATIKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEVHELFR -------CCHHHHHH	12.54	-
9	Nitrated tyrosine	EVHELFRYFRMPELI CHHHHHHHHCCHHHH	6.55	-
9	Nitration	EVHELFRYFRMPELI CHHHHHHHHCCHHHH	6.55	-
9	Phosphorylation	EVHELFRYFRMPELI CHHHHHHHHCCHHHH	6.55	24759943
52	Acetylation	ATRPKALKPPCDLSM HCCCHHCCCCCCCCC	52.34	23864654
52	Malonylation	ATRPKALKPPCDLSM HCCCHHCCCCCCCCC	52.34	26073543
52	Ubiquitination	ATRPKALKPPCDLSM HCCCHHCCCCCCCCC	52.34	-
55	S-nitrosocysteine	PKALKPPCDLSMQSV CHHCCCCCCCCCCEE	12.79	-
55	Glutathionylation	PKALKPPCDLSMQSV CHHCCCCCCCCCCEE	12.79	24333276
55	S-nitrosylation	PKALKPPCDLSMQSV CHHCCCCCCCCCCEE	12.79	22178444
55	S-palmitoylation	PKALKPPCDLSMQSV CHHCCCCCCCCCCEE	12.79	28526873
58	Phosphorylation	LKPPCDLSMQSVEIA CCCCCCCCCCEEEEE	11.09	103260429
74	Phosphorylation	TTDGIRRSAVLEDDK CCCCCCCCEEECCCE	16.93	81017891
81	Acetylation	SAVLEDDKLLVYYYD CEEECCCEEEEEEEC	56.92	23201123
81	Ubiquitination	SAVLEDDKLLVYYYD CEEECCCEEEEEEEC	56.92	-
85	Phosphorylation	EDDKLLVYYYDDVRT CCCEEEEEEECCHHH	9.04	-
86	Nitrated tyrosine	DDKLLVYYYDDVRTM CCEEEEEEECCHHHH	7.92	-
86	Nitration	DDKLLVYYYDDVRTM CCEEEEEEECCHHHH	7.92	-
109	S-nitrosocysteine	QVSNNGPCLGSRKPN EECCCCCCCCCCCCC	7.72	-
109	Glutathionylation	QVSNNGPCLGSRKPN EECCCCCCCCCCCCC	7.72	24333276
109	S-nitrosylation	QVSNNGPCLGSRKPN EECCCCCCCCCCCCC	7.72	22178444
109	S-palmitoylation	QVSNNGPCLGSRKPN EECCCCCCCCCCCCC	7.72	28526873
114	Ubiquitination	GPCLGSRKPNQPYEW CCCCCCCCCCCCCCE	50.44	27667366
133	S-nitrosocysteine	EVAELAECIGSGLIQ HHHHHHHHHCCCHHH	3.38	-
133	S-nitrosylation	EVAELAECIGSGLIQ HHHHHHHHHCCCHHH	3.38	21278135
133	S-palmitoylation	EVAELAECIGSGLIQ HHHHHHHHHCCCHHH	3.38	28526873
136	O-linked_Glycosylation	ELAECIGSGLIQKGF HHHHHHCCCHHHCCC	15.54	-
197	Phosphorylation	IVNKAELSVIFADKP EEEHHHEEEEECCCH	12.50	81017843
203	Acetylation	LSVIFADKPEKAKLL EEEEECCCHHHHHHH	52.20	23954790
203	Ubiquitination	LSVIFADKPEKAKLL EEEEECCCHHHHHHH	52.20	-
208	Acetylation	ADKPEKAKLLLEGVE CCCHHHHHHHHHHHH	51.22	23576753
208	Malonylation	ADKPEKAKLLLEGVE CCCHHHHHHHHHHHH	51.22	26320211
208	Succinylation	ADKPEKAKLLLEGVE CCCHHHHHHHHHHHH	51.22	24315375
208	Ubiquitination	ADKPEKAKLLLEGVE CCCHHHHHHHHHHHH	51.22	27667366
217	Acetylation	LLEGVENKLTPCLKI HHHHHHCCCCCCEEE	39.99	22733758
217	Ubiquitination	LLEGVENKLTPCLKI HHHHHHCCCCCCEEE	39.99	-
221	S-nitrosocysteine	VENKLTPCLKIIVIM HHCCCCCCEEEEEEE	5.21	-
221	S-nitrosylation	VENKLTPCLKIIVIM HHCCCCCCEEEEEEE	5.21	21278135
221	S-palmitoylation	VENKLTPCLKIIVIM HHCCCCCCEEEEEEE	5.21	26165157
230	Phosphorylation	KIIVIMDSYGSDLVE EEEEEEECCCHHHHH	17.64	19060867
231	Phosphorylation	IIVIMDSYGSDLVER EEEEEECCCHHHHHH	19.18	23140645
233	Phosphorylation	VIMDSYGSDLVERGK EEEECCCHHHHHHHH	21.38	30352176
241	Malonylation	DLVERGKKCGVEIIS HHHHHHHHCCCEEEE	38.76	26320211
241	Succinylation	DLVERGKKCGVEIIS HHHHHHHHCCCEEEE	38.76	24315375
241	Ubiquitination	DLVERGKKCGVEIIS HHHHHHHHCCCEEEE	38.76	-
242	S-nitrosocysteine	LVERGKKCGVEIISL HHHHHHHCCCEEEEH	9.34	-
242	S-nitrosylation	LVERGKKCGVEIISL HHHHHHHCCCEEEEH	9.34	22178444
242	S-palmitoylation	LVERGKKCGVEIISL HHHHHHHCCCEEEEH	9.34	28526873
262	Malonylation	LGRVNRVKPKPPEPE HCCCCCCCCCCCCCC	44.05	26320211
264	Acetylation	RVNRVKPKPPEPEDL CCCCCCCCCCCCCCC	68.44	2415105
264	Malonylation	RVNRVKPKPPEPEDL CCCCCCCCCCCCCCC	68.44	26320211
275	S-nitrosocysteine	PEDLAIICFTSGTTG CCCCEEEEEECCCCC	2.19	-
275	S-nitrosylation	PEDLAIICFTSGTTG CCCCEEEEEECCCCC	2.19	21278135
275	S-palmitoylation	PEDLAIICFTSGTTG CCCCEEEEEECCCCC	2.19	28526873
277	Phosphorylation	DLAIICFTSGTTGNP CCEEEEEECCCCCCC	23.10	23140645
278	Phosphorylation	LAIICFTSGTTGNPK CEEEEEECCCCCCCC	17.56	81017907
280	Phosphorylation	IICFTSGTTGNPKGA EEEEECCCCCCCCCC	31.15	25521595
281	Phosphorylation	ICFTSGTTGNPKGAM EEEECCCCCCCCCCE	38.19	108494763
298	S-nitrosocysteine	HQNIINDCSGFIKAT CCHHHHCCCHHHHHH	3.56	-
298	S-nitrosylation	HQNIINDCSGFIKAT CCHHHHCCCHHHHHH	3.56	22178444
298	S-palmitoylation	HQNIINDCSGFIKAT CCHHHHCCCHHHHHH	3.56	28526873
357	Acetylation	RLLMDDLKVLQPTIF HHHHHHHHHHCCCHH	48.14	23576753
357	Malonylation	RLLMDDLKVLQPTIF HHHHHHHHHHCCCHH	48.14	26073543
357	Ubiquitination	RLLMDDLKVLQPTIF HHHHHHHHHHCCCHH	48.14	-
385	Phosphorylation	IFGQANTSLKRWLLD HHCCCCHHHHHHHHH	31.53	81017859
387	Acetylation	GQANTSLKRWLLDFA CCCCHHHHHHHHHHH	41.10	23576753
387	Succinylation	GQANTSLKRWLLDFA CCCCHHHHHHHHHHH	41.10	24315375
387	Ubiquitination	GQANTSLKRWLLDFA CCCCHHHHHHHHHHH	41.10	27667366
396	Acetylation	WLLDFASKRKEAELR HHHHHHHHHCHHHHH	65.15	7623881
396	Ubiquitination	WLLDFASKRKEAELR HHHHHHHHHCHHHHH	65.15	-
411	Phosphorylation	SGIVRNNSLWDKLIF CCCCCCCCHHHHHHH	34.09	22817900
415	Acetylation	RNNSLWDKLIFHKIQ CCCCHHHHHHHHHHH	31.72	23201123
415	Ubiquitination	RNNSLWDKLIFHKIQ CCCCHHHHHHHHHHH	31.72	-
420	Acetylation	WDKLIFHKIQSSLGG HHHHHHHHHHHHCCC	31.52	23201123
420	Malonylation	WDKLIFHKIQSSLGG HHHHHHHHHHHHCCC	31.52	26320211
420	Ubiquitination	WDKLIFHKIQSSLGG HHHHHHHHHHHHCCC	31.52	27667366
423	Phosphorylation	LIFHKIQSSLGGKVR HHHHHHHHHCCCEEE	30.88	25521595
424	Phosphorylation	IFHKIQSSLGGKVRL HHHHHHHHCCCEEEE	18.04	23737553
428	Ubiquitination	IQSSLGGKVRLMITG HHHHCCCEEEEEEEC	23.53	27667366
440	Phosphorylation	ITGAAPVSATVLTFL EECCCCCHHHHHHHH	19.70	23737553
442	Phosphorylation	GAAPVSATVLTFLRT CCCCCHHHHHHHHHH	14.45	18852063
503	Phosphorylation	EEMNYLASKGEGEVC HHHHHHHCCCCCCEE	38.30	81017875
504	Malonylation	EMNYLASKGEGEVCV HHHHHHCCCCCCEEE	56.21	26073543
510	S-nitrosocysteine	SKGEGEVCVKGANVF CCCCCCEEECCCCCC	1.97	-
510	S-nitrosylation	SKGEGEVCVKGANVF CCCCCCEEECCCCCC	1.97	21278135
512	Malonylation	GEGEVCVKGANVFKG CCCCEEECCCCCCCE	47.37	26320211
512	Succinylation	GEGEVCVKGANVFKG CCCCEEECCCCCCCE	47.37	24315375
512	Ubiquitination	GEGEVCVKGANVFKG CCCCEEECCCCCCCE	47.37	-
518	Acetylation	VKGANVFKGYLKDPA ECCCCCCCEECCCHH	42.22	23864654
518	Succinylation	VKGANVFKGYLKDPA ECCCCCCCEECCCHH	42.22	23954790
518	Ubiquitination	VKGANVFKGYLKDPA ECCCCCCCEECCCHH	42.22	27667366
522	Malonylation	NVFKGYLKDPARTAE CCCCEECCCHHHHHH	53.86	26320211
522	Succinylation	NVFKGYLKDPARTAE CCCCEECCCHHHHHH	53.86	23954790
522	Ubiquitination	NVFKGYLKDPARTAE CCCCEECCCHHHHHH	53.86	-
533	Acetylation	RTAEALDKDGWLHTG HHHHHHCCCCCEECC	60.02	23864654
533	Malonylation	RTAEALDKDGWLHTG HHHHHHCCCCCEECC	60.02	26320211
533	Succinylation	RTAEALDKDGWLHTG HHHHHHCCCCCEECC	60.02	23954790
533	Ubiquitination	RTAEALDKDGWLHTG HHHHHHCCCCCEECC	60.02	27667366
539	Phosphorylation	DKDGWLHTGDIGKWL CCCCCEECCCHHCCC	34.09	-
544	Acetylation	LHTGDIGKWLPNGTL EECCCHHCCCCCCCE	45.98	23864654
552	Acetylation	WLPNGTLKIIDRKKH CCCCCCEEEEECCHH	37.14	23864654
552	Malonylation	WLPNGTLKIIDRKKH CCCCCCEEEEECCHH	37.14	26320211
552	Succinylation	WLPNGTLKIIDRKKH CCCCCCEEEEECCHH	37.14	23954790
552	Ubiquitination	WLPNGTLKIIDRKKH CCCCCCEEEEECCHH	37.14	-
562	Acetylation	DRKKHIFKLAQGEYI ECCHHHHHHHCCCCC	42.16	23954790
562	Malonylation	DRKKHIFKLAQGEYI ECCHHHHHHHCCCCC	42.16	26320211
562	Ubiquitination	DRKKHIFKLAQGEYI ECCHHHHHHHCCCCC	42.16	27667366
573	Acetylation	GEYIAPEKIENIYLR CCCCCHHHEECEEEC	55.02	23954790
621	Phosphorylation	QKRGLQGSFEELCRN HHCCCCCCHHHHHHC	19.27	25521595
626	S-nitrosocysteine	QGSFEELCRNKDINK CCCHHHHHHCCCHHH	5.22	-
626	S-nitrosylation	QGSFEELCRNKDINK CCCHHHHHHCCCHHH	5.22	21278135
626	S-palmitoylation	QGSFEELCRNKDINK CCCHHHHHHCCCHHH	5.22	28526873
629	Acetylation	FEELCRNKDINKAIL HHHHHHCCCHHHHHH	40.40	23864654
633	Acetylation	CRNKDINKAILDDLL HHCCCHHHHHHHHHH	36.82	23864654
633	Ubiquitination	CRNKDINKAILDDLL HHCCCHHHHHHHHHH	36.82	-
641	Acetylation	AILDDLLKLGKEAGL HHHHHHHHHHHHHCC	63.59	23954790
641	Malonylation	AILDDLLKLGKEAGL HHHHHHHHHHHHHCC	63.59	26073543
641	Ubiquitination	AILDDLLKLGKEAGL HHHHHHHHHHHHHCC	63.59	-
644	Acetylation	DDLLKLGKEAGLKPF HHHHHHHHHHCCCCH	55.62	23864654
644	Malonylation	DDLLKLGKEAGLKPF HHHHHHHHHHCCCCH	55.62	26320211
644	Ubiquitination	DDLLKLGKEAGLKPF HHHHHHHHHHCCCCH	55.62	-
649	Acetylation	LGKEAGLKPFEQVKG HHHHHCCCCHHHCCC	46.90	23864654
649	Malonylation	LGKEAGLKPFEQVKG HHHHHCCCCHHHCCC	46.90	26320211
649	Succinylation	LGKEAGLKPFEQVKG HHHHHCCCCHHHCCC	46.90	23806337
649	Ubiquitination	LGKEAGLKPFEQVKG HHHHHCCCCHHHCCC	46.90	27667366
655	Ubiquitination	LKPFEQVKGIAVHPE CCCHHHCCCEEECHH	44.27	-
672	Phosphorylation	SIDNGLLTPTLKAKR EECCCCCCCCCCCCC	21.19	30352176
674	Phosphorylation	DNGLLTPTLKAKRPE CCCCCCCCCCCCCHH	35.34	23984901
676	Ubiquitination	GLLTPTLKAKRPELR CCCCCCCCCCCHHHH	55.10	27667366
688	Phosphorylation	ELRNYFRSQIDELYA HHHHHHHHHHHHHHH	22.91	81017883
696	Phosphorylation	QIDELYATIKI---- HHHHHHHHCCC----	14.83	29899451
698	Ubiquitination	DELYATIKI------ HHHHHHCCC------	37.70	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACSL1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACSL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACSL1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ACSL1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey.";
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
Mol. Cell 23:607-618(2006).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-544, AND MASS SPECTROMETRY.
PubMed: 16916647