A2MG_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: A2MG_MOUSE
• UniProt AC: Q6GQT1
• Protein Name: Alpha-2-macroglobulin-P
• Gene Name: A2m {ECO:0000312|MGI:MGI:2449119}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1474
• Subcellular Localization: Secreted.
• Protein Description: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity)..
• Protein Sequence: MGKRWLPSLALLPLPPPLLLLLLLLLPTNASAPQKPIYMVMVPSLLHAGTPEKGCLLFNHLNETVTVKVSMESVRGNQSLFTDLVVDKDLFHCASFIVPQSSSNEVMFLTVQVKGPTHEFRRRSTVLIKTKESLVFAQTDKPIYKPGQMVRFRVVSLDENFHPLNELIPLLYIQDSKKNRIAQWQNFRLEGGLKQLSFPLSSEPTQGSYKVVIRTESGRTVEHPFSVKEFVLPKFEVKVAVPETITILEEEMNVSVCGIYTYGKPVPGHVTVNICRKYSNPSSCFGEESLAFCEKFSQQLDGRGCFSQLVKTKSFQLKRQEYEMQLDVNAKIQEEGTGVEETGKGLTKITRTITKLSFVNVDTHFRQGIPFVGQVLLVDGRGTPIPYEMIFIGADEANQNINTTTDKNGLARFSINTDDIMGTSLTVRAKYKDSNVCYGFRWLTEENVEAWHTANAVFSPSRSFVHLESLPYKLRCEQTLAVQAHYILNDEAVLERKELVFYYLMMAKGGIVRAGTHVLPVTQGHKKGHFSILISMETDLAPVARLVLYTILPNGEVVGDTVKYEIEKCLANKVDLVFHPNIGLPATRAFLSVMASPQSLCGLRAVDQSVLLTKPEAELSASLVYDLLPVKDLTGFPKGVNQQEEDTNGCLKQNDTYINGILYSPVQNTNEEDMYGFLKDMGLKVFTNLNIRKPKVCERLGVNKIPAAYHLVSQGHMDAFLESSESPTETTRSYFPETWIWDLVIVDSTGVAEMEVTVPDTITEWKAGAFCLSNDTGLGLSPVIDFQAFQPFFVDLTMPYSVIRGEAFTLKATVLNYLQTCIRVGVQLEASPDFLATPEEKEQKSHCICMNERHTMSWAVIPKSLGNVNFTVSAEALDSKELCRNEVPVVPERGKKDTIIKSLLVEPEGLENEVTFNSLLCPTGAEVSEQISLKLPSDVVEESARASVTVLGDILGSAMQNTQDLLKMPYGCGEQNMVLFAPNIYVLDYLNETEQLTQEIKTKAITYLNTGYQRQLNYKHRDGSYSTFGDKPGRSHANTWLTAFVLKSFAQARRYIFIDESHITQALTWLSQQQKDNGCFRSSGSLLNNAMKGGVEDEVTLSAYITIALLEMSLPVTHPVVRNALFCLDTAWKSARRGASGNHVYTKALLAYAFALAGNQDTKKEILKSLDEEAVKEDNSVHWTRAQKPRVPADLWYQPQAPSAEVEMTAYVLLAYLTTELVPTREDLTAAMLIVKWLTKQQNSHGGFSSTQDTVVALHALSKYGAATFTRAKKAAHVTIQSSGAFYTKFQVNNDNQLLLQRVTLPTVPGDYTAKVAGEGCVYLQTSLKYSVLPREKEFPFALVVQTLPGTCEDLKAHTTFQISLNISYIGSRSDSNMAIADVKMVSGFIPLKPTVKMLERSVHVSRTEVSNNHVLIYLDKVSNQMLTLFFMVQQDIPVRDLKPAIVKVYDYYEKDEFAVAKYSAPCSAGYGNA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	N-linked_Glycosylation	CLLFNHLNETVTVKV EEEEECCCCCEEEEE		-
77	N-linked_Glycosylation	SMESVRGNQSLFTDL EHHHHCCCCCCCEEE		-
95	Phosphorylation	KDLFHCASFIVPQSS CCHHCEEEEEEECCC		28059163
124	Phosphorylation	THEFRRRSTVLIKTK CCCCCCCCEEEEEEC		25338131
253	N-linked_Glycosylation	TILEEEMNVSVCGIY EEEEHHCCEEEEEEE		-
352	Phosphorylation	GLTKITRTITKLSFV CHHHHHHEEEEEEEE		28285833
402	N-linked_Glycosylation	DEANQNINTTTDKNG CCCCCCCCCCCCCCC		-
634	Phosphorylation	LLPVKDLTGFPKGVN HCCHHHCCCCCCCCC		22871156
654	N-linked_Glycosylation	TNGCLKQNDTYINGI CCCCCCCCCCEECCE		-
774	N-linked_Glycosylation	AGAFCLSNDTGLGLS CEEEEECCCCCCCCC		-
869	N-linked_Glycosylation	PKSLGNVNFTVSAEA CCCCCCCEEEEEHHH		-
949	Phosphorylation	ESARASVTVLGDILG HHHHHHHHHHHHHHH		28576409
991	N-linked_Glycosylation	IYVLDYLNETEQLTQ EEEEECCCCHHHHHH		-
1075	Ubiquitination	TWLSQQQKDNGCFRS HHHHHHCCCCCCCCC		-
1169	Phosphorylation	TKKEILKSLDEEAVK HHHHHHHHCCHHHHH		28464351
1209	Phosphorylation	PSAEVEMTAYVLLAY CCCCHHHHHHHHHHH		28576409
1282	Phosphorylation	AAHVTIQSSGAFYTK CEEEEEECCCCEEEE		22871156
1288	Phosphorylation	QSSGAFYTKFQVNND ECCCCEEEEEEECCC		22871156
1366	N-linked_Glycosylation	TTFQISLNISYIGSR CEEEEEEEEEEECCC		-
1448	Ubiquitination	DLKPAIVKVYDYYEK HCCCEEEEEEEEECC		22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of A2MG_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of A2MG_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of A2MG_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of A2MG_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.