TKT_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TKT_MOUSE
• UniProt AC: P40142
• Protein Name: Transketolase
• Gene Name: Tkt
• Organism: Mus musculus (Mouse).
• Sequence Length: 623
• Protein Description: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate..
• Protein Sequence: MEGYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKALDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLPEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAYTGKYFDKASYRVYCMLGDGEVSEGSVWEAMAFAGIYKLDNLVAIFDINRLGQSDPAPLQHQVDIYQKRCEAFGWHTIIVDGHSVEELCKAFGQAKHQPTAIIAKTFKGRGITGIEDKEAWHGKPLPKNMAEQIIQEIYSQVQSKKKILATPPQEDAPSVDIANIRMPTPPSYKVGDKIATRKAYGLALAKLGHASDRIIALDGDTKNSTFSELFKKEHPDRFIECYIAEQNMVSIAVGCATRDRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPMSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYSNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAESLKKDKISIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSAAVVGEPGVTVTRLAVSQVPRSGKPAELLKMFGIDKDAIVQAVKGLVTKG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEGYHKPD -------CCCCCCCC	8.99	23806337
4	Phosphorylation	----MEGYHKPDQQK ----CCCCCCCCHHH	8.05	25367039
6	Acetylation	--MEGYHKPDQQKLQ --CCCCCCCCHHHHH	41.63	23806337
6	Malonylation	--MEGYHKPDQQKLQ --CCCCCCCCHHHHH	41.63	26320211
6	Ubiquitination	--MEGYHKPDQQKLQ --CCCCCCCCHHHHH	41.63	-
11	Acetylation	YHKPDQQKLQALKDT CCCCCHHHHHHHHHH	36.61	23201123
16	Acetylation	QQKLQALKDTANRLR HHHHHHHHHHHHHHH	56.92	23806337
16	Malonylation	QQKLQALKDTANRLR HHHHHHHHHHHHHHH	56.92	26320211
16	Ubiquitination	QQKLQALKDTANRLR HHHHHHHHHHHHHHH	56.92	27667366
39	Phosphorylation	AAGSGHPTSCCSAAE CCCCCCCCCCCCHHH	28.81	20139300
40	Phosphorylation	AGSGHPTSCCSAAEI CCCCCCCCCCCHHHH	19.99	20139300
59	Malonylation	FFHTMRYKALDPRNP HHHHHHCCCCCCCCC	31.91	26320211
102	Malonylation	AELLNLRKISSDLDG HHHHCHHHCCCCCCC	50.54	26320211
102	Ubiquitination	AELLNLRKISSDLDG HHHHCHHHCCCCCCC	50.54	-
104	Phosphorylation	LLNLRKISSDLDGHP HHCHHHCCCCCCCCC	22.34	29176673
105	Phosphorylation	LNLRKISSDLDGHPV HCHHHCCCCCCCCCC	45.74	29176673
114	Ubiquitination	LDGHPVPKQAFTDVA CCCCCCCCHHHCCCC	55.26	22790023
133	Glutathionylation	GQGLGAACGMAYTGK CCHHHHHCCHHHCCC	3.67	24333276
144	Acetylation	YTGKYFDKASYRVYC HCCCCCCCCCEEEEE	29.36	22826441
144	Malonylation	YTGKYFDKASYRVYC HCCCCCCCCCEEEEE	29.36	26320211
144	Ubiquitination	YTGKYFDKASYRVYC HCCCCCCCCCEEEEE	29.36	-
204	Acetylation	HQVDIYQKRCEAFGW HHHHHHHHHHHHHCC	41.88	23236377
204	Malonylation	HQVDIYQKRCEAFGW HHHHHHHHHHHHHCC	41.88	26320211
204	Ubiquitination	HQVDIYQKRCEAFGW HHHHHHHHHHHHHCC	41.88	27667366
206	Glutathionylation	VDIYQKRCEAFGWHT HHHHHHHHHHHCCEE	5.95	24333276
232	Acetylation	CKAFGQAKHQPTAII HHHHCCCCCCCCEEE	34.58	23806337
232	Malonylation	CKAFGQAKHQPTAII HHHHCCCCCCCCEEE	34.58	26320211
232	Ubiquitination	CKAFGQAKHQPTAII HHHHCCCCCCCCEEE	34.58	27667366
241	Acetylation	QPTAIIAKTFKGRGI CCCEEEEEECCCCCC	44.05	22826441
241	Succinylation	QPTAIIAKTFKGRGI CCCEEEEEECCCCCC	44.05	23954790
241	Ubiquitination	QPTAIIAKTFKGRGI CCCEEEEEECCCCCC	44.05	-
254	Acetylation	GITGIEDKEAWHGKP CCCCCCCHHHHCCCC	36.22	23236377
254	Malonylation	GITGIEDKEAWHGKP CCCCCCCHHHHCCCC	36.22	26320211
254	Ubiquitination	GITGIEDKEAWHGKP CCCCCCCHHHHCCCC	36.22	27667366
260	Acetylation	DKEAWHGKPLPKNMA CHHHHCCCCCCHHHH	30.41	23201123
260	Malonylation	DKEAWHGKPLPKNMA CHHHHCCCCCCHHHH	30.41	26320211
260	Ubiquitination	DKEAWHGKPLPKNMA CHHHHCCCCCCHHHH	30.41	27667366
264	Acetylation	WHGKPLPKNMAEQII HCCCCCCHHHHHHHH	68.02	23954790
264	Ubiquitination	WHGKPLPKNMAEQII HCCCCCCHHHHHHHH	68.02	22790023
275	Nitration	EQIIQEIYSQVQSKK HHHHHHHHHHHHCCC	7.72	-
275	Phosphorylation	EQIIQEIYSQVQSKK HHHHHHHHHHHHCCC	7.72	25177544
276	Phosphorylation	QIIQEIYSQVQSKKK HHHHHHHHHHHCCCC	29.54	26745281
280	Phosphorylation	EIYSQVQSKKKILAT HHHHHHHCCCCCCCC	47.81	26643407
281	Acetylation	IYSQVQSKKKILATP HHHHHHCCCCCCCCC	40.78	133965
281	Malonylation	IYSQVQSKKKILATP HHHHHHCCCCCCCCC	40.78	26073543
281	Ubiquitination	IYSQVQSKKKILATP HHHHHHCCCCCCCCC	40.78	-
282	Malonylation	YSQVQSKKKILATPP HHHHHCCCCCCCCCC	50.74	26073543
282	Ubiquitination	YSQVQSKKKILATPP HHHHHCCCCCCCCCC	50.74	-
283	Ubiquitination	SQVQSKKKILATPPQ HHHHCCCCCCCCCCC	46.84	22790023
287	Phosphorylation	SKKKILATPPQEDAP CCCCCCCCCCCCCCC	31.86	25521595
295	Phosphorylation	PPQEDAPSVDIANIR CCCCCCCCCCCCCCC	33.86	27180971
305	Phosphorylation	IANIRMPTPPSYKVG CCCCCCCCCCCCCCC	38.19	27180971
308	Phosphorylation	IRMPTPPSYKVGDKI CCCCCCCCCCCCCHH	38.50	26643407
309	Phosphorylation	RMPTPPSYKVGDKIA CCCCCCCCCCCCHHH	18.57	26643407
310	Acetylation	MPTPPSYKVGDKIAT CCCCCCCCCCCHHHH	44.04	22826441
310	Malonylation	MPTPPSYKVGDKIAT CCCCCCCCCCCHHHH	44.04	26320211
310	Ubiquitination	MPTPPSYKVGDKIAT CCCCCCCCCCCHHHH	44.04	27667366
314	Acetylation	PSYKVGDKIATRKAY CCCCCCCHHHHHHHH	28.45	23806337
314	Malonylation	PSYKVGDKIATRKAY CCCCCCCHHHHHHHH	28.45	26320211
314	Succinylation	PSYKVGDKIATRKAY CCCCCCCHHHHHHHH	28.45	23806337
319	Acetylation	GDKIATRKAYGLALA CCHHHHHHHHHHHHH	41.42	22826441
319	Malonylation	GDKIATRKAYGLALA CCHHHHHHHHHHHHH	41.42	26320211
319	Ubiquitination	GDKIATRKAYGLALA CCHHHHHHHHHHHHH	41.42	27667366
327	Acetylation	AYGLALAKLGHASDR HHHHHHHHHCCCCCC	56.71	22826441
327	Ubiquitination	AYGLALAKLGHASDR HHHHHHHHHCCCCCC	56.71	22790023
342	Phosphorylation	IIALDGDTKNSTFSE EEEECCCCCCCCHHH	37.34	22817900
343	Acetylation	IALDGDTKNSTFSEL EEECCCCCCCCHHHH	54.35	22826441
343	Ubiquitination	IALDGDTKNSTFSEL EEECCCCCCCCHHHH	54.35	22790023
345	Phosphorylation	LDGDTKNSTFSELFK ECCCCCCCCHHHHHH	32.17	27180971
346	Phosphorylation	DGDTKNSTFSELFKK CCCCCCCCHHHHHHH	40.34	21743459
348	Phosphorylation	DTKNSTFSELFKKEH CCCCCCHHHHHHHHC	33.22	21743459
352	Acetylation	STFSELFKKEHPDRF CCHHHHHHHHCCCCE	70.63	23954790
352	Succinylation	STFSELFKKEHPDRF CCHHHHHHHHCCCCE	70.63	23954790
352	Ubiquitination	STFSELFKKEHPDRF CCHHHHHHHHCCCCE	70.63	27667366
386	S-palmitoylation	RDRTVPFCSTFAAFF CCCCCCCHHHHHHHH	2.83	26165157
387	Phosphorylation	DRTVPFCSTFAAFFT CCCCCCHHHHHHHHH	27.26	20139300
388	Phosphorylation	RTVPFCSTFAAFFTR CCCCCHHHHHHHHHH	20.62	20139300
444	Phosphorylation	FRSVPMSTVFYPSDG HHCCCCEEEECCCCC	14.37	20139300
447	Phosphorylation	VPMSTVFYPSDGVAT CCCEEEECCCCCCCC	9.48	-
449	Phosphorylation	MSTVFYPSDGVATEK CEEEECCCCCCCCHH	35.30	26525534
456	Ubiquitination	SDGVATEKAVELAAN CCCCCCHHHHHHHHC	54.07	22790023
468	Glutathionylation	AANTKGICFIRTSRP HHCCCCEEEEECCCC	2.94	24333276
482	Phosphorylation	PENAIIYSNNEDFQV CCCEEEECCCCCCCC	23.83	29899451
493	Ubiquitination	DFQVGQAKVVLKSKD CCCCCEEEEEEECCC	25.62	22790023
498	Phosphorylation	QAKVVLKSKDDQVTV EEEEEEECCCCCEEE	36.84	29899451
499	Acetylation	AKVVLKSKDDQVTVI EEEEEECCCCCEEEE	64.83	23201123
499	Malonylation	AKVVLKSKDDQVTVI EEEEEECCCCCEEEE	64.83	26073543
499	Ubiquitination	AKVVLKSKDDQVTVI EEEEEECCCCCEEEE	64.83	-
504	Phosphorylation	KSKDDQVTVIGAGVT ECCCCCEEEEECCCC	10.77	29899451
523	Acetylation	LAAAESLKKDKISIR HHHHHHHCCCCCEEE	69.11	23954790
528	Phosphorylation	SLKKDKISIRVLDPF HHCCCCCEEEEECCC	15.30	30387612
536	Phosphorylation	IRVLDPFTIKPLDRK EEEECCCCCCCCCCE	33.22	21454597
538	Acetylation	VLDPFTIKPLDRKLI EECCCCCCCCCCEEH	36.15	23806337
538	Ubiquitination	VLDPFTIKPLDRKLI EECCCCCCCCCCEEH	36.15	22790023
543	Acetylation	TIKPLDRKLILDSAR CCCCCCCEEHHHHCC	39.28	22826441
543	Malonylation	TIKPLDRKLILDSAR CCCCCCCEEHHHHCC	39.28	26320211
543	Ubiquitination	TIKPLDRKLILDSAR CCCCCCCEEHHHHCC	39.28	-
590	Phosphorylation	TVTRLAVSQVPRSGK EEEEEEEECCCCCCC	21.61	27180971
595	Phosphorylation	AVSQVPRSGKPAELL EEECCCCCCCHHHHH	45.13	22817900
597	Malonylation	SQVPRSGKPAELLKM ECCCCCCCHHHHHHH	42.15	26320211
597	Ubiquitination	SQVPRSGKPAELLKM ECCCCCCCHHHHHHH	42.15	27667366
603	Acetylation	GKPAELLKMFGIDKD CCHHHHHHHHCCCHH	44.82	23236377
609	Acetylation	LKMFGIDKDAIVQAV HHHHCCCHHHHHHHH	47.33	23806337
609	Malonylation	LKMFGIDKDAIVQAV HHHHCCCHHHHHHHH	47.33	26073543

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TKT_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TKT_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TKT_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TKT_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-275, AND MASSSPECTROMETRY.
PubMed: 18034455