| UniProt ID | ERLN1_MOUSE | |
|---|---|---|
| UniProt AC | Q91X78 | |
| Protein Name | Erlin-1 | |
| Gene Name | Erlin1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 346 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass type II membrane protein. Associated with lipid raft-like domains of the endoplasmic reticulum membrane.. |
|
| Protein Description | Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (By similarity).. | |
| Protein Sequence | MTQARLLVAAVVGLVAILLYASIHKIEEGHLAVYYRGGALLTSPSGPGYHIMLPFITTFRSVQTTLQTDEVKNVPCGTSGGVMIYIDRIEVVNMLAPYAVFDIVRNYTADYDKTLIFNKIHHELNQFCSAHTLQEVYIELFDQIDENLKQALQKDLNTMAPGLTIQAVRVTKPKIPEAIRRNFELMEAEKTKLLIAAQKQKVVEKEAETERKRAVIEAEKIAQVAKIRFQQKVMEKETEKRISEIEDAAFLAREKAKADAEYYAAHKYATSNKHKLTPEYLELKKYQAIASNSKIYFGSNIPSMFVDSSCALKYSDGRTGREDSLPPEEAREPSGESPIQNKENAG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 108 | N-linked_Glycosylation | FDIVRNYTADYDKTL HHHHHHCCCCCCCEE | 19.32 | - | |
| 191 | Phosphorylation | ELMEAEKTKLLIAAQ HHHHHHHHHHHHHHH | 20.59 | - | |
| 267 | Acetylation | AEYYAAHKYATSNKH HHHHHHHHHHHCCCC | 31.67 | - | |
| 269 | Acetylation | YYAAHKYATSNKHKL HHHHHHHHHCCCCCC | 14.89 | - | |
| 310 | Glutathionylation | SMFVDSSCALKYSDG HHEECCCCEEECCCC | 6.27 | 24333276 | |
| 321 | Methylation | YSDGRTGREDSLPPE CCCCCCCCCCCCCHH | 43.89 | 18959865 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ERLN1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ERLN1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ERLN1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ERLN1_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
