GLYR1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLYR1_MOUSE
• UniProt AC: Q922P9
• Protein Name: Putative oxidoreductase GLYR1
• Gene Name: Glyr1
• Organism: Mus musculus (Mouse).
• Sequence Length: 546
• Subcellular Localization: Nucleus .
• Protein Description: Putative oxidoreductase that is recruited on chromatin and promotes KDM1B demethylase activity. Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6..
• Protein Sequence: MAAVSLRLGDLVWGKLGRYPPWPGKIVNPPKDLKKPRGKKCFFVKFFGTEDHAWIKVEQLKPYHAHKEEMIKINKGKRFQQAVDAVEEFLRRAKGKDQTSSHTSADDKNRRNSSEERSRPNSGDEKRKLSLSEGKVKKNMGEGKKRVTSGSADRGSKCLKRAQEQSPRKRGRPPKDEKDLTIPESSTVKGMMAGPMAAFKWQPTATEPVKDADPHFHHFLLSQTEKPAVCYQAITKKLKICEEETGSTSIQAADSTAVNGSITPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKEGARLGRTPAEVVSTCDITFACVSDPKAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAQVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAYIH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
113	Phosphorylation	DDKNRRNSSEERSRP CHHCCCCCCCHHHCC	37.00	23737553
114	Phosphorylation	DKNRRNSSEERSRPN HHCCCCCCCHHHCCC	47.21	26824392
118	Phosphorylation	RNSSEERSRPNSGDE CCCCCHHHCCCCHHH	56.20	29514104
122	Phosphorylation	EERSRPNSGDEKRKL CHHHCCCCHHHHHHC	50.75	23684622
130	Phosphorylation	GDEKRKLSLSEGKVK HHHHHHCHHCCCCHH	32.65	26824392
132	Phosphorylation	EKRKLSLSEGKVKKN HHHHCHHCCCCHHCC	40.71	28833060
148	Phosphorylation	GEGKKRVTSGSADRG CCCCCCCCCCCCHHH	31.25	20531401
149	Phosphorylation	EGKKRVTSGSADRGS CCCCCCCCCCCHHHH	28.08	23684622
151	Phosphorylation	KKRVTSGSADRGSKC CCCCCCCCCHHHHHH	27.11	23684622
156	Phosphorylation	SGSADRGSKCLKRAQ CCCCHHHHHHHHHHH	22.53	-
166	Phosphorylation	LKRAQEQSPRKRGRP HHHHHHHCCHHCCCC	26.39	25266776
204	Phosphorylation	AAFKWQPTATEPVKD EECCCCCCCCCCCCC	30.98	-
206	Phosphorylation	FKWQPTATEPVKDAD CCCCCCCCCCCCCCC	43.21	-
245	Phosphorylation	LKICEEETGSTSIQA HCCCHHHHCCCEEEE	39.45	30635358
247	Phosphorylation	ICEEETGSTSIQAAD CCHHHHCCCEEEECC	26.80	30635358
248	Phosphorylation	CEEETGSTSIQAADS CHHHHCCCEEEECCC	31.06	30635358
249	Phosphorylation	EEETGSTSIQAADST HHHHCCCEEEECCCC	17.88	30635358
255	Phosphorylation	TSIQAADSTAVNGSI CEEEECCCCCCCCCC	17.34	30635358
256	Phosphorylation	SIQAADSTAVNGSIT EEEECCCCCCCCCCC	34.86	30635358
261	Phosphorylation	DSTAVNGSITPTDKK CCCCCCCCCCCCCCC	20.34	30635358
263	Phosphorylation	TAVNGSITPTDKKIG CCCCCCCCCCCCCEE	23.10	30635358
265	Phosphorylation	VNGSITPTDKKIGFL CCCCCCCCCCCEEEE	52.37	30635358
328	Ubiquitination	FACVSDPKAAKDLVL EEEECCHHHHHHCEE	67.00	-
331	Ubiquitination	VSDPKAAKDLVLGPS ECCHHHHHHCEECCC	57.35	-
360	Phosphorylation	MSTVDADTVTELAQV CCCCCCHHHHHHHHH	30.92	28576409
488	Ubiquitination	NILQGNFKPDFYLKY HHHCCCCCCCHHHHH	47.91	-
498	Ubiquitination	FYLKYIQKDLRLAIA HHHHHHHHHHHHHHH	49.53	-
528	Ubiquitination	NEVYKRAKALDQSDN HHHHHHHHHHCCCCC	54.22	-
533	Phosphorylation	RAKALDQSDNDMSAV HHHHHCCCCCHHHHH	37.74	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLYR1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLYR1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLYR1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GLYR1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.