3BHS1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 3BHS1_MOUSE
• UniProt AC: P24815
• Protein Name: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
• Gene Name: Hsd3b1
• Organism: Mus musculus (Mouse).
• Sequence Length: 373
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
• Protein Description: 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids..
• Protein Sequence: MAGWSCLVTGAGGFVGQRIIKMLVQEKELQEVRALDKVFRPETKEEFSKLQTKTKVTVLEGDILDAQCLRRACQGISVVIHTAAVIDVTGVIPRQTILDVNLKGTQNLLEACVQASVPAFIFCSSVDVAGPNSYKKIVLNGHEEQNHESTWSDPYPYSKKMAEKAVLAANGSMLKNGGTLNTCALRPMYIYGERSPFIFNAIIRALKNKGILCVTGKFSIANPVYVENVAWAHILAARGLRDPKKSTSIQGQFYYISDDTPHQSYDDLNYTLSKEWGLRPNASWSLPLPLLYWLAFLLETVSFLLRPVYRYRPLFNRHLITLSNSTFTFSYKKAQRDLGYEPLVNWEEAKQKTSEWIGTIVEQHREILDTKCQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
68	S-palmitoylation	GDILDAQCLRRACQG CCCCCHHHHHHHHCC	3.23	28526873
77	Phosphorylation	RRACQGISVVIHTAA HHHHCCCEEEEEECE	19.70	-
152	Phosphorylation	QNHESTWSDPYPYSK HCCCCCCCCCCCCCH	28.88	23684622
158	Phosphorylation	WSDPYPYSKKMAEKA CCCCCCCCHHHHHHH	22.69	23684622
159	Ubiquitination	SDPYPYSKKMAEKAV CCCCCCCHHHHHHHH	40.50	-
164	Ubiquitination	YSKKMAEKAVLAANG CCHHHHHHHHHHCCC	33.97	-
172	Phosphorylation	AVLAANGSMLKNGGT HHHHCCCCCCCCCCC	22.28	25177544
350	Ubiquitination	LVNWEEAKQKTSEWI CCCHHHHHHHHHHHH	56.45	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 3BHS1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 3BHS1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 3BHS1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of 3BHS1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.