APOA1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: APOA1_MOUSE
• UniProt AC: Q00623
• Protein Name: Apolipoprotein A-I
• Gene Name: Apoa1
• Organism: Mus musculus (Mouse).
• Sequence Length: 264
• Subcellular Localization: Secreted.
• Protein Description: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility..
• Protein Sequence: MKAVVLAVALVFLTGSQAWHVWQQDEPQSQWDKVKDFANVYVDAVKDSGRDYVSQFESSSLGQQLNLNLLENWDTLGSTVSQLQERLGPLTRDFWDNLEKETDWVRQEMNKDLEEVKQKVQPYLDEFQKKWKEDVELYRQKVAPLGAELQESARQKLQELQGRLSPVAEEFRDRMRTHVDSLRTQLAPHSEQMRESLAQRLAELKSNPTLNEYHTRAKTHLKTLGEKARPALEDLRHSLMPMLETLKTQVQSVIDKASETLTAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Ubiquitination	QSQWDKVKDFANVYV HHHHHHHHHHHHHHH	53.52	-
41	Nitration	VKDFANVYVDAVKDS HHHHHHHHHHHHHHC	7.75	-
46	Acetylation	NVYVDAVKDSGRDYV HHHHHHHHHCCCCHH	48.15	23954790
46	Ubiquitination	NVYVDAVKDSGRDYV HHHHHHHHHCCCCHH	48.15	-
46	Succinylation	NVYVDAVKDSGRDYV HHHHHHHHHCCCCHH	48.15	23954790
58	Phosphorylation	DYVSQFESSSLGQQL CHHHHHHHCHHHHHH	26.90	22817900
60	Phosphorylation	VSQFESSSLGQQLNL HHHHHHCHHHHHHCH	45.88	22817900
75	Phosphorylation	NLLENWDTLGSTVSQ HHHHCHHHHCHHHHH	25.32	22817900
109	Methionine sulfoxide	TDWVRQEMNKDLEEV HHHHHHHHHHCHHHH	5.97	-
109	Oxidation	TDWVRQEMNKDLEEV HHHHHHHHHHCHHHH	5.97	-
119	Ubiquitination	DLEEVKQKVQPYLDE CHHHHHHHHHHHHHH	36.80	-
129	Ubiquitination	PYLDEFQKKWKEDVE HHHHHHHHHHHHHHH	66.96	-
129	Succinylation	PYLDEFQKKWKEDVE HHHHHHHHHHHHHHH	66.96	23954790
130	Ubiquitination	YLDEFQKKWKEDVEL HHHHHHHHHHHHHHH	53.36	-
130	Acetylation	YLDEFQKKWKEDVEL HHHHHHHHHHHHHHH	53.36	23201123
132	Succinylation	DEFQKKWKEDVELYR HHHHHHHHHHHHHHH	53.57	23954790
132	Acetylation	DEFQKKWKEDVELYR HHHHHHHHHHHHHHH	53.57	23201123
141	Ubiquitination	DVELYRQKVAPLGAE HHHHHHHHHHCCCHH	31.22	-
156	Ubiquitination	LQESARQKLQELQGR HHHHHHHHHHHHHHC	46.73	27667366
156	Acetylation	LQESARQKLQELQGR HHHHHHHHHHHHHHC	46.73	21728379
165	Phosphorylation	QELQGRLSPVAEEFR HHHHHCHHHHHHHHH	18.90	24719451
181	Phosphorylation	RMRTHVDSLRTQLAP HHHHHHHHHHHHCCC	20.75	24719451
190	Phosphorylation	RTQLAPHSEQMRESL HHHCCCCCHHHHHHH	28.59	24719451
193	Methionine sulfoxide	LAPHSEQMRESLAQR CCCCCHHHHHHHHHH	4.51	-
193	Oxidation	LAPHSEQMRESLAQR CCCCCHHHHHHHHHH	4.51	16876491
205	Ubiquitination	AQRLAELKSNPTLNE HHHHHHHHCCCCHHH	39.43	27667366
240	Methionine sulfoxide	EDLRHSLMPMLETLK HHHHHHHHHHHHHHH	1.74	-
240	Oxidation	EDLRHSLMPMLETLK HHHHHHHHHHHHHHH	1.74	16876491
242	Methionine sulfoxide	LRHSLMPMLETLKTQ HHHHHHHHHHHHHHH	3.08	-
242	Oxidation	LRHSLMPMLETLKTQ HHHHHHHHHHHHHHH	3.08	16876491
256	Acetylation	QVQSVIDKASETLTA HHHHHHHHHHHHHCC	42.56	55163799
256	Ubiquitination	QVQSVIDKASETLTA HHHHHHHHHHHHHCC	42.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of APOA1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of APOA1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of APOA1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APOA1_MOUSE	Apoa1	physical	11744719
APOB_MOUSE	Apob	physical	15654758
APOE_MOUSE	Apoe	genetic	15654758

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.