A1AT1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: A1AT1_MOUSE
• UniProt AC: P07758
• Protein Name: Alpha-1-antitrypsin 1-1
• Gene Name: Serpina1a
• Organism: Mus musculus (Mouse).
• Sequence Length: 413
• Subcellular Localization: Secreted .
• Protein Description: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin..
• Protein Sequence: MTPSISWGLLLLAGLCCLVPSFLAEDVQETDTSQKDQSPASHEIATNLGDFAISLYRELVHQSNTSNIFFSPVSIATAFAMLSLGSKGDTHTQILEGLQFNLTQTSEADIHKSFQHLLQTLNRPDSELQLSTGNGLFVNNDLKLVEKFLEEAKNHYQAEVFSVNFAESEEAKKVINDFVEKGTQGKIAEAVKKLDQDTVFALANYILFKGKWKKPFDPENTEEAEFHVDESTTVKVPMMTLSGMLHVHHCSTLSSWVLLMDYAGNATAVFLLPDDGKMQHLEQTLSKELISKFLLNRRRRLAQIHFPRLSISGEYNLKTLMSPLGITRIFNNGADLSGITEENAPLKLSQAVHKAVLTIDETGTEAAAVTVLQMVPMSMPPILRFDHPFLFIIFEEHTQSPIFLGKVVDPTHK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	DTSQKDQSPASHEIA CCCCCCCCCHHHHHH	32.35	23984901
41	Phosphorylation	QKDQSPASHEIATNL CCCCCCHHHHHHHHH	25.66	27180971
46	Phosphorylation	PASHEIATNLGDFAI CHHHHHHHHHHHHHH	36.32	23984901
64	N-linked_Glycosylation	RELVHQSNTSNIFFS HHHHHHCCCCCCCCC	40.74	17330941
101	N-linked_Glycosylation	ILEGLQFNLTQTSEA HHHHCEECCCCCCHH	29.26	17330941
147	Ubiquitination	NDLKLVEKFLEEAKN CCHHHHHHHHHHHHH	48.01	22790023
147	Acetylation	NDLKLVEKFLEEAKN CCHHHHHHHHHHHHH	48.01	23954790
173	Ubiquitination	AESEEAKKVINDFVE CCCHHHHHHHHHHHH	56.23	22790023
181	Acetylation	VINDFVEKGTQGKIA HHHHHHHHCCCCHHH	63.05	23954790
181	Ubiquitination	VINDFVEKGTQGKIA HHHHHHHHCCCCHHH	63.05	-
181	Succinylation	VINDFVEKGTQGKIA HHHHHHHHCCCCHHH	63.05	23954790
186	Ubiquitination	VEKGTQGKIAEAVKK HHHCCCCHHHHHHHH	29.00	27667366
209	Ubiquitination	LANYILFKGKWKKPF HHHHHHHCCCCCCCC	57.02	27667366
214	Acetylation	LFKGKWKKPFDPENT HHCCCCCCCCCCCCC	50.21	21728379
265	N-linked_Glycosylation	LLMDYAGNATAVFLL HHECCCCCEEEEEEC	26.41	-
287	Ubiquitination	HLEQTLSKELISKFL HHHHHHCHHHHHHHH	60.70	22790023
292	Malonylation	LSKELISKFLLNRRR HCHHHHHHHHHHHHH	32.79	25418362
292	Ubiquitination	LSKELISKFLLNRRR HCHHHHHHHHHHHHH	32.79	27667366
292	Acetylation	LSKELISKFLLNRRR HCHHHHHHHHHHHHH	32.79	23864654
315	Ubiquitination	RLSISGEYNLKTLMS CCEECCCCCHHHHCC	29.35	27667366
318	Ubiquitination	ISGEYNLKTLMSPLG ECCCCCHHHHCCCCC	35.65	22790023
347	Ubiquitination	TEENAPLKLSQAVHK CCCCCCHHHHHHHHH	45.06	22790023
370	Ubiquitination	GTEAAAVTVLQMVPM CCHHHHEEEECCCCC	15.69	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of A1AT1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of A1AT1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of A1AT1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CELA1_MOUSE	Cela1	physical	11961105
ELNE_MOUSE	Elane	physical	11961105

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides.";
Bernhard O.K., Kapp E.A., Simpson R.J.;
J. Proteome Res. 6:987-995(2007).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-64 AND ASN-101, AND MASSSPECTROMETRY.
PubMed: 17330941