DPOLB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DPOLB_MOUSE
• UniProt AC: Q8K409
• Protein Name: DNA polymerase beta
• Gene Name: Polb
• Organism: Mus musculus (Mouse).
• Sequence Length: 335
• Subcellular Localization: Nucleus. Cytoplasm. Cytoplasmic in normal conditions. Translocates to the nucleus following DNA damage (By similarity)..
• Protein Description: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases (By similarity)..
• Protein Sequence: MSKRKAPQETLNGGITDMLVELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVTGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFEDFEKRIPREEMLQMQDIVLNEIKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPNFTSESSKQPKLLHRVVEQLQKVHFITDTLSKGETKFMGVCQLPSEKDGKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEQDIFDYIQWRYREPKDRSE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	Acetylation	VGTKIAEKIDEFLAT CCHHHHHHHHHHHHH	46.57	23806337
81	Acetylation	DEFLATGKLRKLEKI HHHHHHCHHHHHHHH	40.54	23806337
83	Methylation	FLATGKLRKLEKIRQ HHHHCHHHHHHHHHC	45.02	-
104	Phosphorylation	INFLTRVTGIGPSAA HHHHHHHHCCCHHHH	21.57	28066266
109	Phosphorylation	RVTGIGPSAARKFVD HHHCCCHHHHHHHHH	29.37	28066266
152	Methylation	DFEKRIPREEMLQMQ HHHHHCCHHHHHHHH	50.57	-
204	Phosphorylation	HPNFTSESSKQPKLL CCCCCCCCCCCCHHH	42.47	-
205	Phosphorylation	PNFTSESSKQPKLLH CCCCCCCCCCCHHHH	31.12	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DPOLB_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
41	K	ubiquitylation	Ubiquitinated at Lys-41, Lys-61 and Lys-81: monoubiquitinated by HUWE1/ARF-BP1.	-
61	K	ubiquitylation	Ubiquitinated at Lys-41, Lys-61 and Lys-81: monoubiquitinated by HUWE1/ARF-BP1.	-
81	K	ubiquitylation	Ubiquitinated at Lys-41, Lys-61 and Lys-81: monoubiquitinated by HUWE1/ARF-BP1.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DPOLB_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DPOLB_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.