COQ8A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COQ8A_MOUSE
• UniProt AC: Q60936
• Protein Name: Atypical kinase COQ8A, mitochondrial {ECO:0000305}
• Gene Name: Coq8a {ECO:0000250|UniProtKB:Q8NI60}
• Organism: Mus musculus (Mouse).
• Sequence Length: 645
• Subcellular Localization: Mitochondrion . Membrane ; Single-pass membrane protein .
• Protein Description: Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. [PubMed: 27499294 Its substrate specificity is unclear: does not show any protein kinase activity]
• Protein Sequence: MAAMLGDAIMVAKGLAKLTQAAVETHLQNLGLGGELLLAARALQSTAVEQFSMVFGKVQGQDKHEDSYATENFEDLEAEVQFSTPQAAGTSLDFSAASSLDQSLSPSHSQGPAPAYASSGPFREAGLPGQATSPMGRVNGRLFVDHRDLFLANGIQRRSFHQDQSSVGGLTAEDIEKARQAKARPESKPHKQMLSERARERKVPVTRIGRLANFGGLAVGLGIGALAEVAKKSLRSENSTGKKAVLDSSPFLSEANAERIVSTLCKVRGAALKLGQMLSIQDDAFINPHLAKIFERVRQSADFMPLKQMTKTLNSDLGPHWRDKLEYFEERPFAAASIGQVHLARMKGGREVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRRELTLECDYQREAAYAKKFRELLKDHPFFYVPEIVDELCSPHVLTTELISGFPLDQAEGLSQEVRNEICYNILVLCLRELFEFHVMQTDPNWSNFFYDPQQHKVALLDFGATREYDRSFTDLYIQVIRAAADQDREAVLKKSIEMKFLTGYEVKAMEDAHLDAILILGEAFASEEPFDFGTQSTTEKIHNLIPVMLKHRLIPPPEETYSLHRKMGGSFLICSKLKARFPCKAMFEEAYSNYCRMKSGLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
188	Acetylation	AKARPESKPHKQMLS HHCCCCCCHHHHHHH		23201123
191	Ubiquitination	RPESKPHKQMLSERA CCCCCHHHHHHHHHH		22790023
243	Ubiquitination	SENSTGKKAVLDSSP CCCCCCCCEECCCCC		22790023
253	Phosphorylation	LDSSPFLSEANAERI CCCCCCCCHHCHHHH		29899451
265	S-palmitoylation	ERIVSTLCKVRGAAL HHHHHHHHHHHHHHH		26165157
265	S-nitrosocysteine	ERIVSTLCKVRGAAL HHHHHHHHHHHHHHH		-
266	Acetylation	RIVSTLCKVRGAALK HHHHHHHHHHHHHHH		23576753
266	Ubiquitination	RIVSTLCKVRGAALK HHHHHHHHHHHHHHH		22790023
307	Acetylation	SADFMPLKQMTKTLN CCCCCCHHHHHHHHH		23201123
311	Acetylation	MPLKQMTKTLNSDLG CCHHHHHHHHHCCCC		23864654
311	Ubiquitination	MPLKQMTKTLNSDLG CCHHHHHHHHHCCCC		22790023
312	Phosphorylation	PLKQMTKTLNSDLGP CHHHHHHHHHCCCCH		28576409
324	Acetylation	LGPHWRDKLEYFEER CCHHHHHHHHHHHHC		23864654
324	Ubiquitination	LGPHWRDKLEYFEER CCHHHHHHHHHHHHC		22790023
403	S-nitrosocysteine	RRELTLECDYQREAA HHHCCHHCHHHHHHH		-
511	Phosphorylation	DFGATREYDRSFTDL CCCCCCCCCCCHHHH		21082442
514	Phosphorylation	ATREYDRSFTDLYIQ CCCCCCCCHHHHHHH		22817900
516	Phosphorylation	REYDRSFTDLYIQVI CCCCCCHHHHHHHHH		21183079
536	Acetylation	QDREAVLKKSIEMKF CCHHHHHHHHHHHHC		2393397
593	Acetylation	NLIPVMLKHRLIPPP HHHHHHHHCCCCCCC		23201123
617	S-nitrosocysteine	MGGSFLICSKLKARF CCCEEEEECCCHHHC		-
617	S-palmitoylation	MGGSFLICSKLKARF CCCEEEEECCCHHHC		28526873
638	S-nitrosocysteine	EEAYSNYCRMKSGLQ HHHHHHHHHHHHCCC		-
638	S-palmitoylation	EEAYSNYCRMKSGLQ HHHHHHHHHHHHCCC		28526873

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COQ8A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COQ8A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COQ8A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of COQ8A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.