SPEG_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPEG_MOUSE
• UniProt AC: Q62407
• Protein Name: Striated muscle-specific serine/threonine-protein kinase
• Gene Name: Speg
• Organism: Mus musculus (Mouse).
• Sequence Length: 3262
• Subcellular Localization: Isoform 3: Nucleus.
• Protein Description: Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells..
• Protein Sequence: MQKARGTRGEDAGTRAPPSPGVPPKRAKVGAGRGVLVTGDGAGAPVFLRPLKNAAVCAGSDVRLRVVVSGTPQPSLSWFRDGQLLPPPAPEPSCLWLRSCGAQDAGVYSCSAQNERGQASCEAVLTVLEVRDSETAEDDISDVPGTQRLELRDDRAFSTPTGGSDTLVGTSLDTPPTSVTGTSEEQVSWWGSGQTVLEQEAGSGGGTRPLPGSPRQAQTTGAGPRHLGVEPLVRASRANLVGASWGSEDSLSVASDLYGSAFSLYRGRALSIHVSIPPSGLHREEPDLQPQPASDALRPRPALPPPSKSALLPPPSPRVGKRALPGPSTQPPATPTSPHRRAQEPSLPEDITTTEEKRGKKPKSSGPSLAGTVESRPQTPLSEASGRLSALGRSPRLVRAGSRILDKLQFFEERRRSLERSDSPPAPLRPWVPLRKARSLEQPKSEGGAAWGTPEASQEELRSPRGSVAERRRLFQQKAASLDERTRQRSATSDLELRFAQELGRIRRSTSREELVRSHESLRATLQRAPSPREPGEPPLFSRPSTPKTSRAVSPAATQPPPPSGAGKSGDEPGRPRSRGPVGRTEPGEGPQQEIKRRDQFPLTRSRAIQECRSPVPPYTADPPESRTKAPSGRKREPPAQAVRFLPWATPGVEDSVLPQTLEKNRAGPEAEKRLRRGPEEDGPWGPWDRRGTRSQGKGRRARPTSPELESSDDSYVSAGEEPLEAPVFEIPLQNMVVAPGADVLLKCIITANPPPQVSWKKDGSMLHSEGRLLIRAEGERHTLLLREAQAADAGSYTATATNELGQATCASSLAVRPGGSTSPFSSPITSDEEYLSPPEEFPEPGETWPRTPTMKLSPSQDHDSSDSSSKAPPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGGLCRLRILAAERGDAGFYTCKAVNEYGARQCEARLEVRAHPESRSLAVLAPLQDVDVGAGEMALFECLVAGPADVEVDWLCRGRLLQPALLKCKMHFDGRKCKLLLTSVHEDDSGVYTCKLSTAKDELTCSARLTVRPSLAPLFTRLLEDVEVLEGRAARLDCKISGTPPPSVTWTHFGHPVNEGDNLRLRQDGGLHSLHIARVGSEDEGLYEVSATNTHGQAHCSAQLYVEEPRTAASGPSSKLEKMPSIPEEPEHGDLERLSIPDFLRPLQDLEVGLAKEAMLECQVTGLPYPTISWFHNGHRIQSSDDRRMTQYRDIHRLVFPAVGPQHAGVYKSVIANKLGKAACYAHLYVTDVVPGPPDGAPEVVAVTGRMVTLSWNPPRSLDMAIDPDSLTYTVQHQVLGSDQWTALVTGLREPAWAATGLKKGIQHIFRVLSSSGKSSSKPSAPSEPVQLLEHGPPLEEAPAVLDKQDIVYVVEGQPACVTVTFNHVEAQVVWRSCRGALLEARTGVYELSQPDDDQYCLRICRVSRRDLGPLTCSARNRHGTKACSVTLELAEAPRFESIMEDVEVGPGETARFAVVVEGKPLPDIMWYKDEVLLAESNHVSFVYEENECSLVLLSAGSQDGGVYTCTARNLAGEVSCKAELSVLSAQTAMEVEGVGEDEEHRGRRLSDYYDIHQEIGRGAFSYLRRVVERSSGLEFAAKFIPSQAKPKASARREARLLARLQHGCVLYFHEAFERRRGLVIVTELCTEELLERMARKPTVCESETRTYMRQVLEGICYLHQSHVLHLDVKPENLLVWDGAGGEEQVRICDFGNAQELTPGEPQYCQYGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQDRLRPTAEETLEHPWFKTEAKGAEVSTDHLKLFLSRRRWQRSQISYKCHLVLRPIPELLRAPPERVWVAMPRRQPPSGGLSSSSDSEEEELEELPSVPRPLQPEFSGSRVSLTDIPTEDEALGTPEAGAATPMDWQEQERTPSKDQEAPSPEALPSPGQESPDGPSPRRPELRRGSSAESALPRVGSREPGRSLHKAASVELPQRRSPSPGATRLTRGGLGEGEYAQRLQALRQRLLRGGPEDGKVSGLRGPLLESLGGRARDPRMARAASSEAAPHHQPPPESRGLQKSSSFSQGEAEPRGRHRRAGAPLEIPVARLGARRLQESPSLSALSETQPPSPARPSVPKLSITKSPEPSAVTSRDSPQPPEPQPVPEKVPEPKPEPVRAAKPAQPPLALQMPTQPLTPYAQIMQSLQLSSPTLSPQDPAVPPSEPKPHAAVFARVASPPPGVSEKRVPSARTPPVLAEKARVPTVPPRPGSSLSGSIENLESEAVFEAKFKRSRESPLSRGLRLLSRSRSEERGPFRGAEDDGIYRPSPAGTPLELVRRPERSRSVQDLRVAGEPGLVRRLSLSLSQKLRRTPPGQRHPAWESRSGDGESSEGGSSARASPVLAVRRRLSSTLERLSSRLQRSGSSEDSGGASGRSTPLFGRLRRATSEGESLRRLGVPHNQLGSQTGATTPSAESLGSEASGTSGSSAPGESRSRHRWGLSRLRKDKGLSQPNLSSSVQEDLGHQYVPSESDFPPVFHIKLKDQVLLEGEAATLLCLPAACPAPRISWMKDKQSLRSEPSVVIVSCKDGRQLLSIPRAGKRHAGLYECSATNVLGSITSSCTVAVARIPGKLAPPEVPQTYHDTALVVWKPGDGRAPCTYTLERRVDGESVWHPVSSGIPDCYYNVTQLPVGVTVRFRVACSNRAGQGPFSNPSEKVFIRGTPDSPAQPAAAPRDAPVTSGPTRAPPPDSPTSLAPTPALAPPASQASTLSPSTSSMSANQALSSLKAVGPPPATPPRKHRGLLATQQAEPSPPSIVVTPSEPRSFVPDTGTLTPTSSPQGVKPAPSSTSLYMVTSFVSAPPAPQAPAPEPPPEPTKVTVRSLSPAKEVVSSPTPESTTLRQGPPQKPYTFLEEKARGRFGVVRSCRENATGRTFVAKIVPYAAEGKRRVLQEYEVLRTLHHERLMSLHEAYITPRYLVLIAESCGNRELLCGLSDRFRYSEDDVATYVVQLLQGLDYLHGHHVLHLDIKPDNLLLAADNALKIVDFGSAQPYNPQALKPLGHRTGTLEFMAPEMVKGDPIGSATDIWGAGVLTYIMLSGYSPFYEPDPQETEARIVGGRFDAFQLYPNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWLQDAYLMKLRRQTLTFTTNRLKEFLGEQRRRRAEAATRHKVLLRSYPGSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4 (in isoform 3)	Phosphorylation	-	18.16	26824392
4 (in isoform 4)	Phosphorylation	-	18.16	26824392
19	Phosphorylation	AGTRAPPSPGVPPKR CCCCCCCCCCCCCHH	32.97	23737553
33	Methylation	RAKVGAGRGVLVTGD HCCCCCCCCEEECCC	31.36	24129315
141	Phosphorylation	ETAEDDISDVPGTQR CCCCCCCCCCCCCCE	39.28	28464351
236	Phosphorylation	VEPLVRASRANLVGA CHHHHHHHHHCEECC	22.74	26824392
268	Methylation	AFSLYRGRALSIHVS CHHEECCCEEEEEEE	24.29	16188177
316	Phosphorylation	SALLPPPSPRVGKRA HCCCCCCCCCCCCCC	30.98	26824392
328	Phosphorylation	KRALPGPSTQPPATP CCCCCCCCCCCCCCC	45.66	23737553
329	Phosphorylation	RALPGPSTQPPATPT CCCCCCCCCCCCCCC	48.50	23737553
334	Phosphorylation	PSTQPPATPTSPHRR CCCCCCCCCCCCCCC	32.64	23737553
336	Phosphorylation	TQPPATPTSPHRRAQ CCCCCCCCCCCCCCC	51.00	23737553
337	Phosphorylation	QPPATPTSPHRRAQE CCCCCCCCCCCCCCC	21.66	24899341
346	Phosphorylation	HRRAQEPSLPEDITT CCCCCCCCCCCCCCC	56.66	28464351
364	Phosphorylation	KRGKKPKSSGPSLAG HCCCCCCCCCCCCCC	49.40	27742792
365	Phosphorylation	RGKKPKSSGPSLAGT CCCCCCCCCCCCCCC	61.93	27742792
368	Phosphorylation	KPKSSGPSLAGTVES CCCCCCCCCCCCCCC	34.08	28059163
372	Phosphorylation	SGPSLAGTVESRPQT CCCCCCCCCCCCCCC	18.59	23737553
375	Phosphorylation	SLAGTVESRPQTPLS CCCCCCCCCCCCCHH	44.95	22322096
379	Phosphorylation	TVESRPQTPLSEASG CCCCCCCCCHHHHHH	28.95	22322096
382	Phosphorylation	SRPQTPLSEASGRLS CCCCCCHHHHHHHHH	32.11	22322096
385	Phosphorylation	QTPLSEASGRLSALG CCCHHHHHHHHHHCC	22.01	23737553
389	Phosphorylation	SEASGRLSALGRSPR HHHHHHHHHCCCCHH	21.78	22322096
394	Phosphorylation	RLSALGRSPRLVRAG HHHHCCCCHHHHHHC	16.75	24899341
402	Phosphorylation	PRLVRAGSRILDKLQ HHHHHHCHHHHHHHH	18.37	23608596
421	Phosphorylation	RRRSLERSDSPPAPL HHHHHHCCCCCCCCC	32.82	27742792
423	Phosphorylation	RSLERSDSPPAPLRP HHHHCCCCCCCCCCC	33.75	27742792
439	Phosphorylation	VPLRKARSLEQPKSE CCHHCCCCCCCCCCC	40.91	25521595
445	Phosphorylation	RSLEQPKSEGGAAWG CCCCCCCCCCCCCCC	48.43	27742792
453	Phosphorylation	EGGAAWGTPEASQEE CCCCCCCCCCCCHHH	13.78	25521595
457	Phosphorylation	AWGTPEASQEELRSP CCCCCCCCHHHHHCC	36.14	25521595
463	Phosphorylation	ASQEELRSPRGSVAE CCHHHHHCCCCCHHH	31.41	23737553
467	Phosphorylation	ELRSPRGSVAERRRL HHHCCCCCHHHHHHH	21.31	22210690
481	Phosphorylation	LFQQKAASLDERTRQ HHHHHHHCCCHHHHH	41.01	27742792
490	Phosphorylation	DERTRQRSATSDLEL CHHHHHHHHCCHHHH	27.79	24899341
492	Phosphorylation	RTRQRSATSDLELRF HHHHHHHCCHHHHHH	24.82	28066266
493	Phosphorylation	TRQRSATSDLELRFA HHHHHHCCHHHHHHH	39.66	26824392
509	Phosphorylation	ELGRIRRSTSREELV HHHHHHCCCCHHHHH	22.38	23737553
510	Phosphorylation	LGRIRRSTSREELVR HHHHHCCCCHHHHHH	29.96	25521595
511	Phosphorylation	GRIRRSTSREELVRS HHHHCCCCHHHHHHC	38.65	23737553
518	Phosphorylation	SREELVRSHESLRAT CHHHHHHCHHHHHHH	24.91	24899341
521	Phosphorylation	ELVRSHESLRATLQR HHHHCHHHHHHHHHC	20.10	23737553
525	Phosphorylation	SHESLRATLQRAPSP CHHHHHHHHHCCCCC	19.59	23737553
531	Phosphorylation	ATLQRAPSPREPGEP HHHHCCCCCCCCCCC	35.29	26824392
542	Phosphorylation	PGEPPLFSRPSTPKT CCCCCCCCCCCCCCC	51.47	23737553
545	Phosphorylation	PPLFSRPSTPKTSRA CCCCCCCCCCCCCCC	57.12	24899341
546	Phosphorylation	PLFSRPSTPKTSRAV CCCCCCCCCCCCCCC	31.33	24899341
554	Phosphorylation	PKTSRAVSPAATQPP CCCCCCCCCCCCCCC	14.08	25619855
564	Phosphorylation	ATQPPPPSGAGKSGD CCCCCCCCCCCCCCC	47.23	21183079
578	Phosphorylation	DEPGRPRSRGPVGRT CCCCCCCCCCCCCCC	44.25	23737553
614	Phosphorylation	RAIQECRSPVPPYTA HHHHHCCCCCCCCCC	41.74	23737553
620	Phosphorylation	RSPVPPYTADPPESR CCCCCCCCCCCCHHC	30.29	22871156
705	Phosphorylation	KGRRARPTSPELESS CCCCCCCCCCCCCCC	51.89	22210690
706	Phosphorylation	GRRARPTSPELESSD CCCCCCCCCCCCCCC	21.04	22210690
711	Phosphorylation	PTSPELESSDDSYVS CCCCCCCCCCCCCCC	52.25	22210690
712	Phosphorylation	TSPELESSDDSYVSA CCCCCCCCCCCCCCC	35.74	22210690
715	Phosphorylation	ELESSDDSYVSAGEE CCCCCCCCCCCCCCC	32.21	22210690
716	Phosphorylation	LESSDDSYVSAGEEP CCCCCCCCCCCCCCC	12.86	22210690
718	Phosphorylation	SSDDSYVSAGEEPLE CCCCCCCCCCCCCCC	23.48	22210690
802	Phosphorylation	GSYTATATNELGQAT CCEEEEEECHHHCCE	25.52	25367039
809	Phosphorylation	TNELGQATCASSLAV ECHHHCCEECCEEEE	10.75	25367039
835	Phosphorylation	PITSDEEYLSPPEEF CCCCCCCCCCCCHHC	15.50	25367039
858	Phosphorylation	RTPTMKLSPSQDHDS CCCCCCCCCCCCCCC	19.58	24899341
860	Phosphorylation	PTMKLSPSQDHDSSD CCCCCCCCCCCCCCC	44.88	29899451
865	Phosphorylation	SPSQDHDSSDSSSKA CCCCCCCCCCCCCCC	32.40	27742792
866	Phosphorylation	PSQDHDSSDSSSKAP CCCCCCCCCCCCCCC	47.79	27742792
868	Phosphorylation	QDHDSSDSSSKAPPT CCCCCCCCCCCCCCE	38.16	27742792
869	Phosphorylation	DHDSSDSSSKAPPTF CCCCCCCCCCCCCEE	40.63	27742792
870	Phosphorylation	HDSSDSSSKAPPTFK CCCCCCCCCCCCEEE	36.47	27742792
1133	Phosphorylation	LHIARVGSEDEGLYE EEEEECCCCCCCEEE	38.73	22817900
1177	Phosphorylation	SKLEKMPSIPEEPEH HHHHCCCCCCCCCCC	47.48	25521595
1470	Phosphorylation	DLGPLTCSARNRHGT CCCCCCCCCCCCCCC	25.65	28059163
1494	Phosphorylation	AEAPRFESIMEDVEV HHCCCHHHHHCCEEC	25.23	-
1551	Phosphorylation	ECSLVLLSAGSQDGG CEEEEEEECCCCCCC	26.82	-
1603	Phosphorylation	EHRGRRLSDYYDIHQ CHHCCCHHHHHHHHH	23.04	22817900
1697	S-nitrosocysteine	MARKPTVCESETRTY HHCCCCCCHHHHHHH	5.39	-
1697	S-nitrosylation	MARKPTVCESETRTY HHCCCCCCHHHHHHH	5.39	21278135
1949	Phosphorylation	RPLQPEFSGSRVSLT CCCCCCCCCCCEECC	33.91	23737553
1951	Phosphorylation	LQPEFSGSRVSLTDI CCCCCCCCCEECCCC	28.45	23737553
1954	Phosphorylation	EFSGSRVSLTDIPTE CCCCCCEECCCCCCC	25.17	23737553
1956	Phosphorylation	SGSRVSLTDIPTEDE CCCCEECCCCCCCCC	25.11	23737553
1960	Phosphorylation	VSLTDIPTEDEALGT EECCCCCCCCCCCCC	57.30	23737553
1967	Phosphorylation	TEDEALGTPEAGAAT CCCCCCCCCCCCCCC	20.85	23737553
1974	Phosphorylation	TPEAGAATPMDWQEQ CCCCCCCCCCCHHHH	20.72	23737553
1984	Phosphorylation	DWQEQERTPSKDQEA CHHHHCCCCCCCCCC	31.03	27742792
1986	Phosphorylation	QEQERTPSKDQEAPS HHHCCCCCCCCCCCC	48.53	27742792
1993	Phosphorylation	SKDQEAPSPEALPSP CCCCCCCCCCCCCCC	42.28	27742792
1999	Phosphorylation	PSPEALPSPGQESPD CCCCCCCCCCCCCCC	42.38	27742792
2004	Phosphorylation	LPSPGQESPDGPSPR CCCCCCCCCCCCCCC	22.02	26824392
2009	Phosphorylation	QESPDGPSPRRPELR CCCCCCCCCCCHHHC	36.25	23737553
2017	Methylation	PRRPELRRGSSAESA CCCHHHCCCCCHHHC	63.07	58859685
2019	Phosphorylation	RPELRRGSSAESALP CHHHCCCCCHHHCCC	25.27	25521595
2020	Phosphorylation	PELRRGSSAESALPR HHHCCCCCHHHCCCC	38.59	26824392
2023	Phosphorylation	RRGSSAESALPRVGS CCCCCHHHCCCCCCC	34.52	23737553
2042	Phosphorylation	RSLHKAASVELPQRR CCCCCCCCCCCCCCC	22.45	26824392
2050	Phosphorylation	VELPQRRSPSPGATR CCCCCCCCCCCCCCC	31.73	26824392
2052	Phosphorylation	LPQRRSPSPGATRLT CCCCCCCCCCCCCCC	36.89	24899341
2060	Asymmetric dimethylarginine	PGATRLTRGGLGEGE CCCCCCCCCCCCCCH	41.60	-
2060	Methylation	PGATRLTRGGLGEGE CCCCCCCCCCCCCCH	41.60	24129315
2090	Phosphorylation	GPEDGKVSGLRGPLL CCCCCCCCCCCHHHH	35.28	28464351
2099	Phosphorylation	LRGPLLESLGGRARD CCHHHHHHCCCCCCC	32.08	19060867
2114	Phosphorylation	PRMARAASSEAAPHH HHHHHHHCCCCCCCC	27.94	25521595
2115	Phosphorylation	RMARAASSEAAPHHQ HHHHHHCCCCCCCCC	26.91	30635358
2133	Phosphorylation	ESRGLQKSSSFSQGE CCCCCCCCCCCCCCC	20.46	30635358
2134	Phosphorylation	SRGLQKSSSFSQGEA CCCCCCCCCCCCCCC	42.30	30635358
2135	Phosphorylation	RGLQKSSSFSQGEAE CCCCCCCCCCCCCCC	35.69	25521595
2137	Phosphorylation	LQKSSSFSQGEAEPR CCCCCCCCCCCCCCC	38.94	23737553
2144	Methylation	SQGEAEPRGRHRRAG CCCCCCCCCCCCCCC	46.40	24129315
2169	Phosphorylation	GARRLQESPSLSALS HHHHHCCCCCHHHHC	13.56	23737553
2171	Phosphorylation	RRLQESPSLSALSET HHHCCCCCHHHHCCC	44.21	23737553
2173	Phosphorylation	LQESPSLSALSETQP HCCCCCHHHHCCCCC	31.34	27742792
2176	Phosphorylation	SPSLSALSETQPPSP CCCHHHHCCCCCCCC	38.01	27742792
2178	Phosphorylation	SLSALSETQPPSPAR CHHHHCCCCCCCCCC	42.89	23737553
2182	Phosphorylation	LSETQPPSPARPSVP HCCCCCCCCCCCCCC	37.56	26824392
2187	Phosphorylation	PPSPARPSVPKLSIT CCCCCCCCCCCEEEE	45.56	23737553
2196	Phosphorylation	PKLSITKSPEPSAVT CCEEEECCCCCCCCC	26.33	23375375
2200	Phosphorylation	ITKSPEPSAVTSRDS EECCCCCCCCCCCCC	33.44	27742792
2203	Phosphorylation	SPEPSAVTSRDSPQP CCCCCCCCCCCCCCC	20.12	23737553
2204	Phosphorylation	PEPSAVTSRDSPQPP CCCCCCCCCCCCCCC	27.73	23737553
2207	Phosphorylation	SAVTSRDSPQPPEPQ CCCCCCCCCCCCCCC	25.07	23737553
2224	Acetylation	PEKVPEPKPEPVRAA CCCCCCCCCCCCCCC	61.42	6566157
2288	Phosphorylation	AVFARVASPPPGVSE EEEEEECCCCCCCCC	34.77	24899341
2294	Phosphorylation	ASPPPGVSEKRVPSA CCCCCCCCCCCCCCC	43.23	25367039
2300	Phosphorylation	VSEKRVPSARTPPVL CCCCCCCCCCCCCCC	27.76	28542873
2303	Phosphorylation	KRVPSARTPPVLAEK CCCCCCCCCCCCCHH	31.49	26824392
2310	Ubiquitination	TPPVLAEKARVPTVP CCCCCCHHCCCCCCC	35.57	-
2315	Phosphorylation	AEKARVPTVPPRPGS CHHCCCCCCCCCCCC	42.67	23737553
2322	Phosphorylation	TVPPRPGSSLSGSIE CCCCCCCCCCCCCEE	30.68	22210690
2323	Phosphorylation	VPPRPGSSLSGSIEN CCCCCCCCCCCCEEC	32.25	23737553
2325	Phosphorylation	PRPGSSLSGSIENLE CCCCCCCCCCEECCC	32.23	23737553
2327	Phosphorylation	PGSSLSGSIENLESE CCCCCCCCEECCCCH	24.29	26824392
2333	Phosphorylation	GSIENLESEAVFEAK CCEECCCCHHHHHHH	33.74	30635358
2347	Phosphorylation	KFKRSRESPLSRGLR HHHCCCCCCHHHHHH	29.99	30387612
2350	Phosphorylation	RSRESPLSRGLRLLS CCCCCCHHHHHHHHH	27.90	23737553
2359	Phosphorylation	GLRLLSRSRSEERGP HHHHHHCCCCCCCCC	36.46	-
2361	Phosphorylation	RLLSRSRSEERGPFR HHHHCCCCCCCCCCC	45.09	26824392
2376	Phosphorylation	GAEDDGIYRPSPAGT CCCCCCCCCCCCCCC	23.23	25159016
2379	Phosphorylation	DDGIYRPSPAGTPLE CCCCCCCCCCCCCHH	20.55	25159016
2383	Phosphorylation	YRPSPAGTPLELVRR CCCCCCCCCHHHHCC	27.14	25159016
2394	Phosphorylation	LVRRPERSRSVQDLR HHCCCCCCCCHHHHH	27.52	23737553
2396	Phosphorylation	RRPERSRSVQDLRVA CCCCCCCCHHHHHHC	25.94	26824392
2413	Phosphorylation	PGLVRRLSLSLSQKL CCHHHHHHCCHHHHH	17.69	26824392
2415	Phosphorylation	LVRRLSLSLSQKLRR HHHHHHCCHHHHHCC	23.69	24899341
2417	Phosphorylation	RRLSLSLSQKLRRTP HHHHCCHHHHHCCCC	23.15	27742792
2423	Phosphorylation	LSQKLRRTPPGQRHP HHHHHCCCCCCCCCC	27.66	24899341
2436	Phosphorylation	HPAWESRSGDGESSE CCCCCCCCCCCCCCC	50.98	21183079
2441	Phosphorylation	SRSGDGESSEGGSSA CCCCCCCCCCCCCCC	38.94	23737553
2442	Phosphorylation	RSGDGESSEGGSSAR CCCCCCCCCCCCCCC	35.64	23737553
2446	Phosphorylation	GESSEGGSSARASPV CCCCCCCCCCCCCHH	31.51	24899341
2447	Phosphorylation	ESSEGGSSARASPVL CCCCCCCCCCCCHHH	25.67	24899341
2451	Phosphorylation	GGSSARASPVLAVRR CCCCCCCCHHHHHHH	15.24	27742792
2461	Phosphorylation	LAVRRRLSSTLERLS HHHHHHHHHHHHHHH	21.33	24899341
2462	Phosphorylation	AVRRRLSSTLERLSS HHHHHHHHHHHHHHH	41.42	24899341
2463	Phosphorylation	VRRRLSSTLERLSSR HHHHHHHHHHHHHHH	29.30	23737553
2468	Phosphorylation	SSTLERLSSRLQRSG HHHHHHHHHHHHHCC	21.45	23737553
2469	Phosphorylation	STLERLSSRLQRSGS HHHHHHHHHHHHCCC	41.42	23737553
2474	Phosphorylation	LSSRLQRSGSSEDSG HHHHHHHCCCCCCCC	30.02	23737553
2476	Phosphorylation	SRLQRSGSSEDSGGA HHHHHCCCCCCCCCC	31.62	23737553
2477	Phosphorylation	RLQRSGSSEDSGGAS HHHHCCCCCCCCCCC	49.28	23737553
2480	Phosphorylation	RSGSSEDSGGASGRS HCCCCCCCCCCCCCC	34.77	22817900
2484	Phosphorylation	SEDSGGASGRSTPLF CCCCCCCCCCCCCCC	37.70	23737553
2487	Phosphorylation	SGGASGRSTPLFGRL CCCCCCCCCCCCHHC	37.59	23737553
2488	Phosphorylation	GGASGRSTPLFGRLR CCCCCCCCCCCHHCH	23.73	23737553
2498	Phosphorylation	FGRLRRATSEGESLR CHHCHHHCCCCHHHH	26.04	22324799
2499	Phosphorylation	GRLRRATSEGESLRR HHCHHHCCCCHHHHH	42.49	30635358
2503	Phosphorylation	RATSEGESLRRLGVP HHCCCCHHHHHHCCC	37.72	23737553
2516	Phosphorylation	VPHNQLGSQTGATTP CCHHHCCCCCCCCCC	32.91	23737553
2518	Phosphorylation	HNQLGSQTGATTPSA HHHCCCCCCCCCCCH	30.40	23737553
2521	Phosphorylation	LGSQTGATTPSAESL CCCCCCCCCCCHHHH	40.35	23737553
2522	Phosphorylation	GSQTGATTPSAESLG CCCCCCCCCCHHHHC	18.08	23737553
2524	Phosphorylation	QTGATTPSAESLGSE CCCCCCCCHHHHCCC	42.44	23737553
2527	Phosphorylation	ATTPSAESLGSEASG CCCCCHHHHCCCCCC	37.43	23737553
2530	Phosphorylation	PSAESLGSEASGTSG CCHHHHCCCCCCCCC	34.97	23737553
2533	Phosphorylation	ESLGSEASGTSGSSA HHHCCCCCCCCCCCC	38.25	23737553
2535	Phosphorylation	LGSEASGTSGSSAPG HCCCCCCCCCCCCCC	27.67	23737553
2536	Phosphorylation	GSEASGTSGSSAPGE CCCCCCCCCCCCCCC	39.96	23737553
2538	Phosphorylation	EASGTSGSSAPGESR CCCCCCCCCCCCCCC	24.08	23737553
2539	Phosphorylation	ASGTSGSSAPGESRS CCCCCCCCCCCCCCC	41.84	23737553
2544	Phosphorylation	GSSAPGESRSRHRWG CCCCCCCCCCHHHCC	41.28	22210690
2562	Phosphorylation	LRKDKGLSQPNLSSS HHHCCCCCCCCCCHH	52.86	23737553
2567	Phosphorylation	GLSQPNLSSSVQEDL CCCCCCCCHHHHHHH	27.49	23737553
2568	Phosphorylation	LSQPNLSSSVQEDLG CCCCCCCHHHHHHHC	37.38	23737553
2569	Phosphorylation	SQPNLSSSVQEDLGH CCCCCCHHHHHHHCC	25.17	23737553
2578	Phosphorylation	QEDLGHQYVPSESDF HHHHCCCCCCCCCCC	14.51	23737553
2581	Phosphorylation	LGHQYVPSESDFPPV HCCCCCCCCCCCCCE	39.42	23737553
2583	Phosphorylation	HQYVPSESDFPPVFH CCCCCCCCCCCCEEE	49.22	23737553
2629	Phosphorylation	KDKQSLRSEPSVVIV CCHHHCCCCCEEEEE	60.18	28464351
2754	Phosphorylation	VRFRVACSNRAGQGP EEEEEEECCCCCCCC	21.44	24759943
2766	Phosphorylation	QGPFSNPSEKVFIRG CCCCCCCCCCEEEEC	55.06	24759943
2768	Ubiquitination	PFSNPSEKVFIRGTP CCCCCCCCEEEECCC	46.94	-
2774	Phosphorylation	EKVFIRGTPDSPAQP CCEEEECCCCCCCCC	17.67	27742792
2777	Phosphorylation	FIRGTPDSPAQPAAA EEECCCCCCCCCCCC	24.28	25521595
2792	Phosphorylation	PRDAPVTSGPTRAPP CCCCCCCCCCCCCCC	42.90	21454597
2802	Phosphorylation	TRAPPPDSPTSLAPT CCCCCCCCCCCCCCC	35.53	23737553
2804	Phosphorylation	APPPDSPTSLAPTPA CCCCCCCCCCCCCCC	40.08	23737553
2805	Phosphorylation	PPPDSPTSLAPTPAL CCCCCCCCCCCCCCC	26.39	23737553
2809	Phosphorylation	SPTSLAPTPALAPPA CCCCCCCCCCCCCCH	18.65	23737553
2847	Phosphorylation	AVGPPPATPPRKHRG HCCCCCCCCCCCCCC	39.33	26824392
2858	Phosphorylation	KHRGLLATQQAEPSP CCCCCCCCCCCCCCC	22.60	27180971
2864	Phosphorylation	ATQQAEPSPPSIVVT CCCCCCCCCCCEEEC	40.73	27180971
2867	Phosphorylation	QAEPSPPSIVVTPSE CCCCCCCCEEECCCC	31.25	27180971
2871	Phosphorylation	SPPSIVVTPSEPRSF CCCCEEECCCCCCCC	15.37	28542873
2886	Phosphorylation	VPDTGTLTPTSSPQG CCCCCCCCCCCCCCC	25.10	28464351
2934	Phosphorylation	PTKVTVRSLSPAKEV CCEEEEEECCCCCEE	28.94	25159016
2936	Phosphorylation	KVTVRSLSPAKEVVS EEEEEECCCCCEECC	24.86	25159016
2939	Ubiquitination	VRSLSPAKEVVSSPT EEECCCCCEECCCCC	55.19	-
2943	Phosphorylation	SPAKEVVSSPTPEST CCCCEECCCCCCCCC	35.46	25159016
2944	Phosphorylation	PAKEVVSSPTPESTT CCCEECCCCCCCCCC	22.60	27742792
2946	Phosphorylation	KEVVSSPTPESTTLR CEECCCCCCCCCCCC	41.45	25159016
2949	Phosphorylation	VSSPTPESTTLRQGP CCCCCCCCCCCCCCC	28.09	27742792
2950	Phosphorylation	SSPTPESTTLRQGPP CCCCCCCCCCCCCCC	28.34	27742792
2951	Phosphorylation	SPTPESTTLRQGPPQ CCCCCCCCCCCCCCC	29.26	27742792
2999	Ubiquitination	VPYAAEGKRRVLQEY HHHHHCCHHHHHHHH	28.65	-
3026	Phosphorylation	SLHEAYITPRYLVLI HHHHHHCCHHHHHHE	6.77	21183079
3111	Ubiquitination	PYNPQALKPLGHRTG CCCHHHCCCCCCCCC	41.01	-
3261	Phosphorylation	LLRSYPGSP------ HHHCCCCCC------	23.96	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPEG_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPEG_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPEG_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SPEG_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439, AND MASSSPECTROMETRY.
PubMed: 19367708

"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316, AND MASSSPECTROMETRY.
PubMed: 17203969

"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations.";
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.;
Mol. Cell. Proteomics 5:914-922(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481 AND SER-1177, ANDMASS SPECTROMETRY.
PubMed: 16452087