SRSF6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRSF6_MOUSE
• UniProt AC: Q3TWW8
• Protein Name: Serine/arginine-rich splicing factor 6
• Gene Name: Srsf6
• Organism: Mus musculus (Mouse).
• Sequence Length: 339
• Subcellular Localization: Nucleus . Nucleus speckle .
• Protein Description: Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing (By similarity)..
• Protein Sequence: MPRVYIGRLSYNVREKDIQRFFSGYGRLLEIDLKNGYGFVEFEDSRDADDAVYELNSKELCGERVIVEHARGPRRDRDGYSYGSRSGGGGYSSRRTSGRDKYGPPVRTEYRLIVENLSSRCSWQDLKDFMRQAGEVTYADAHKERTNEGVIEFRSYSDMKRALDKLDGTEINGRNIRLIEDKPRTSHRRSYSGSRSRSRSRRRSRSRSRRSSRSRSRSISKSRSRSRSRSKGRSRSRSKGRKSRSKSKSKPKSDRGSHSHSRSRSKDKYGKSRSRSRSRSPKENGKGDIKSKSRSRSQSRSHSPLPAPPSKARSMSPPPKRASRSRSRSRSRSRSSSRD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	KDIQRFFSGYGRLLE HHHHHHHCCCCCEEE		22006019
37	Phosphorylation	EIDLKNGYGFVEFED EEECCCCCEEEEEEC		25367039
45	Phosphorylation	GFVEFEDSRDADDAV EEEEEECCCCCCHHH		22802335
53	Phosphorylation	RDADDAVYELNSKEL CCCCHHHHEECCHHH		25159016
80	Phosphorylation	PRRDRDGYSYGSRSG CCCCCCCCCCCCCCC		21743459
81	Phosphorylation	RRDRDGYSYGSRSGG CCCCCCCCCCCCCCC		21743459
82	Phosphorylation	RDRDGYSYGSRSGGG CCCCCCCCCCCCCCC		21743459
84	Phosphorylation	RDGYSYGSRSGGGGY CCCCCCCCCCCCCCC		21743459
86	Phosphorylation	GYSYGSRSGGGGYSS CCCCCCCCCCCCCCC		27841257
91	Phosphorylation	SRSGGGGYSSRRTSG CCCCCCCCCCCCCCC		23140645
92	Phosphorylation	RSGGGGYSSRRTSGR CCCCCCCCCCCCCCC		23140645
93	Phosphorylation	SGGGGYSSRRTSGRD CCCCCCCCCCCCCCC		23140645
96	Phosphorylation	GGYSSRRTSGRDKYG CCCCCCCCCCCCCCC		23140645
97	Phosphorylation	GYSSRRTSGRDKYGP CCCCCCCCCCCCCCC		23140645
101	Acetylation	RRTSGRDKYGPPVRT CCCCCCCCCCCCCCC		6569527
101	Ubiquitination	RRTSGRDKYGPPVRT CCCCCCCCCCCCCCC		27667366
108	Phosphorylation	KYGPPVRTEYRLIVE CCCCCCCCCHHHHHH		30635358
110	Phosphorylation	GPPVRTEYRLIVENL CCCCCCCHHHHHHCH		30635358
118	Phosphorylation	RLIVENLSSRCSWQD HHHHHCHHHCCCHHH		26824392
119	Phosphorylation	LIVENLSSRCSWQDL HHHHCHHHCCCHHHH		22942356
122	Phosphorylation	ENLSSRCSWQDLKDF HCHHHCCCHHHHHHH		30352176
143	Ubiquitination	VTYADAHKERTNEGV CEEHHHHHHHCCCCE		27667366
146	Phosphorylation	ADAHKERTNEGVIEF HHHHHHHCCCCEEEE		28066266
157	Phosphorylation	VIEFRSYSDMKRALD EEEEECHHHHHHHHH		-
165	Acetylation	DMKRALDKLDGTEIN HHHHHHHHCCCCEEC		23806337
165	Ubiquitination	DMKRALDKLDGTEIN HHHHHHHHCCCCEEC		22790023
182	Acetylation	NIRLIEDKPRTSHRR EEEEECCCCCCCCCC		2384423
185	Phosphorylation	LIEDKPRTSHRRSYS EECCCCCCCCCCCCC		25367039
186	Phosphorylation	IEDKPRTSHRRSYSG ECCCCCCCCCCCCCC		25367039
190	Phosphorylation	PRTSHRRSYSGSRSR CCCCCCCCCCCCHHH		29514104
192	Phosphorylation	TSHRRSYSGSRSRSR CCCCCCCCCCHHHHH		29514104
194	Phosphorylation	HRRSYSGSRSRSRSR CCCCCCCCHHHHHHH		29514104
206	Phosphorylation	RSRRRSRSRSRRSSR HHHHHHHHHHHHHHH		19367708
208	Phosphorylation	RRRSRSRSRRSSRSR HHHHHHHHHHHHHHH		19367708
211	Phosphorylation	SRSRSRRSSRSRSRS HHHHHHHHHHHHHHH		19367708
212	Phosphorylation	RSRSRRSSRSRSRSI HHHHHHHHHHHHHHH		19367708
214	Phosphorylation	RSRRSSRSRSRSISK HHHHHHHHHHHHHHH		20531401
234	Phosphorylation	RSRSKGRSRSRSKGR HHHCCCCCCCHHHCC		23375375
236	Phosphorylation	RSKGRSRSRSKGRKS HCCCCCCCHHHCCCC		23375375
238	Phosphorylation	KGRSRSRSKGRKSRS CCCCCCHHHCCCCCC		23375375
249	Phosphorylation	KSRSKSKSKPKSDRG CCCCCCCCCCCCCCC		19367708
253	Phosphorylation	KSKSKPKSDRGSHSH CCCCCCCCCCCCCCC		27717184
257	Phosphorylation	KPKSDRGSHSHSRSR CCCCCCCCCCCCCCC		27717184
259	Phosphorylation	KSDRGSHSHSRSRSK CCCCCCCCCCCCCCC		27717184
276	Phosphorylation	YGKSRSRSRSRSPKE CCCCCCCCCCCCCCC		19367708
278	Phosphorylation	KSRSRSRSRSPKENG CCCCCCCCCCCCCCC		19367708
280	Phosphorylation	RSRSRSRSPKENGKG CCCCCCCCCCCCCCC		19367708
291	Phosphorylation	NGKGDIKSKSRSRSQ CCCCCCCCCCCCCCC		29899451
293	Phosphorylation	KGDIKSKSRSRSQSR CCCCCCCCCCCCCCC		29899451
295	Phosphorylation	DIKSKSRSRSQSRSH CCCCCCCCCCCCCCC		22324799
297	Phosphorylation	KSKSRSRSQSRSHSP CCCCCCCCCCCCCCC		26824392
299	Phosphorylation	KSRSRSQSRSHSPLP CCCCCCCCCCCCCCC		26824392
301	Phosphorylation	RSRSQSRSHSPLPAP CCCCCCCCCCCCCCC		25521595
303	Phosphorylation	RSQSRSHSPLPAPPS CCCCCCCCCCCCCCH		27087446
310	Phosphorylation	SPLPAPPSKARSMSP CCCCCCCHHHCCCCC		25521595
314	Phosphorylation	APPSKARSMSPPPKR CCCHHHCCCCCCCCC		25521595
316	Phosphorylation	PSKARSMSPPPKRAS CHHHCCCCCCCCCHH		25521595
323	Phosphorylation	SPPPKRASRSRSRSR CCCCCCHHCHHHHHH		21183079
325	Phosphorylation	PPKRASRSRSRSRSR CCCCHHCHHHHHHHH		20531401

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
303	S	Phosphorylation	Kinase	DYRK1A	Q61214	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SRSF6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRSF6_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SRSF6_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.