SEM6D_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEM6D_MOUSE
• UniProt AC: Q76KF0
• Protein Name: Semaphorin-6D
• Gene Name: Sema6d
• Organism: Mus musculus (Mouse).
• Sequence Length: 1073
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections (By similarity)..
• Protein Sequence: MGFLLLWFCVLFLLVSRLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEIPQTEVIPSKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLRTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDDTLAFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAIEVDRSAGPYQNYTVIFVGSEAGVVLKVLAKTSPFSLNDSVLLEEIEAYNPAKCSAESEEDRKVVSLQLDKDHHALYVAFSSCVVRIPLSRCERYGSCKKSCIASRDPYCGWLSQGVCERVTLGMLPGGYEQDTEYGNTAHLGDCHESLPPSTTPDYKIFGGPTSDMEVSSSSVTTVASSPEITSKVIDTWRPKLTSSRKFVVQDDPNTSDFTDTISGIPKGVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNTDTKSMAVDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSEKAHSHGASRKEHPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQSMDHPLTKSSSKREHRRSVDSRNTLNDLLKHLNDPNSNPKAILGEIHMAHQTLMLDPVGPMAEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAVPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTTSVRPLNKYTY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	N-linked_Glycosylation	FRGRPSGNESQHRLD CCCCCCCCCCCCCEE	50.51	-
155	Phosphorylation	YRLRTLEYDGEEISG HEEEEEEECCCEECC	32.15	-
283	N-linked_Glycosylation	SFLKARLNCSVPGDS HHHHHHHCCCCCCCC	15.51	-
435	N-linked_Glycosylation	RSAGPYQNYTVIFVG CCCCCCCCEEEEEEC	28.71	-
461	N-linked_Glycosylation	KTSPFSLNDSVLLEE CCCCCCCCCCCHHHH	38.01	-
631	N-linked_Glycosylation	FVVQDDPNTSDFTDT EEECCCCCCCCCCHH	60.24	-
710	Phosphorylation	SAQSCTDSSGSFAKL HHHHCCCCCCCHHHH	20.60	29899451
711	Phosphorylation	AQSCTDSSGSFAKLN HHHCCCCCCCHHHHC	41.07	29899451
713	Phosphorylation	SCTDSSGSFAKLNGL HCCCCCCCHHHHCCC	24.79	29899451
723	Phosphorylation	KLNGLFDSPVKEYQQ HHCCCCCCHHHHHHH	25.02	22324799
734	Phosphorylation	EYQQNIDSPKLYSNL HHHHCCCCHHHHHHH	21.82	27087446
736	Ubiquitination	QQNIDSPKLYSNLLT HHCCCCHHHHHHHHH	65.10	-
738	Phosphorylation	NIDSPKLYSNLLTSR CCCCHHHHHHHHHCC	11.14	28066266
744	Phosphorylation	LYSNLLTSRKELPPN HHHHHHHCCCCCCCC	41.13	-
773	Phosphorylation	PELAALPTPESTPVL CHHHCCCCCCCCCCC	40.30	27087446
776	Phosphorylation	AALPTPESTPVLHQK HCCCCCCCCCCCCHH	38.93	27087446
777	Phosphorylation	ALPTPESTPVLHQKT CCCCCCCCCCCCHHH	18.76	27087446
811	Phosphorylation	EHPQFFPSSPPPHSP CCCCCCCCCCCCCCC	50.77	26060331
812	Phosphorylation	HPQFFPSSPPPHSPL CCCCCCCCCCCCCCC	41.48	26060331
817	Phosphorylation	PSSPPPHSPLSHGHI CCCCCCCCCCCCCCC	33.05	26060331
820	Phosphorylation	PPPHSPLSHGHIPSA CCCCCCCCCCCCCCE	30.70	26060331
852	Acetylation	NAHKAEKKLQSMDHP CHHHHHHHHHHCCCC	43.17	7711883
866	Acetylation	PLTKSSSKREHRRSV CCCCCCHHHHHHHCC	64.85	7711893
928	Phosphorylation	KVPNREASLYSPPST CCCCCCCCCCCCCCC	24.08	28066266
930	Phosphorylation	PNREASLYSPPSTLP CCCCCCCCCCCCCCC	19.35	28066266
931	Phosphorylation	NREASLYSPPSTLPR CCCCCCCCCCCCCCC	35.31	23527152
934	Phosphorylation	ASLYSPPSTLPRNSP CCCCCCCCCCCCCCC	46.06	28066266
935	Phosphorylation	SLYSPPSTLPRNSPT CCCCCCCCCCCCCCC	46.70	28066266
950	Phosphorylation	KRVDVPTTPGVPMTS CCCCCCCCCCCCCCH	16.39	29472430
956	Phosphorylation	TTPGVPMTSLERQRG CCCCCCCCHHHHHCC	24.88	29899451
957	Phosphorylation	TPGVPMTSLERQRGY CCCCCCCHHHHHCCC	23.21	29899451
969	Phosphorylation	RGYHKNSSQRHSISA CCCCCCHHHCCCEEC	40.40	23375375
973	Phosphorylation	KNSSQRHSISAVPKN CCHHHCCCEECCCCC	22.04	29472430
975	Phosphorylation	SSQRHSISAVPKNLN HHHCCCEECCCCCCC	26.65	29472430
983	Phosphorylation	AVPKNLNSPNGVLLS CCCCCCCCCCCEEEE	23.94	-
994	Phosphorylation	VLLSRQPSMNRGGYM EEEECCCCCCCCCCC	21.98	29895711
1000	Phosphorylation	PSMNRGGYMPTPTGA CCCCCCCCCCCCCCC	11.62	29895711
1026	Phosphorylation	VHLQPSLSRQSSYTS EEECCCCCCCCCCCC	32.39	23737553
1029	Phosphorylation	QPSLSRQSSYTSNGT CCCCCCCCCCCCCCC	24.97	24759943
1030	Phosphorylation	PSLSRQSSYTSNGTL CCCCCCCCCCCCCCC	24.88	25521595
1031	Phosphorylation	SLSRQSSYTSNGTLP CCCCCCCCCCCCCCC	21.31	24759943
1032	Phosphorylation	LSRQSSYTSNGTLPR CCCCCCCCCCCCCCC	20.05	24759943
1033	Phosphorylation	SRQSSYTSNGTLPRT CCCCCCCCCCCCCCC	25.65	24759943
1036	Phosphorylation	SSYTSNGTLPRTGLK CCCCCCCCCCCCCCC	37.53	24759943
1047	Phosphorylation	TGLKRTPSLKPDVPP CCCCCCCCCCCCCCC	48.70	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEM6D_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEM6D_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEM6D_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SEM6D_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.