dbPTM

GP1BB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GP1BB_MOUSE
UniProt AC	P56400
Protein Name	Platelet glycoprotein Ib beta chain
Gene Name	Gp1bb
Organism	Mus musculus (Mouse).
Sequence Length	206
Subcellular Localization	Membrane Single-pass type I membrane protein.
Protein Description	Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium..
Protein Sequence	MGSRPRGALSLLLLLLALLSRPASGCPAPCSCAGTLVDCGRRGLTWASLPAAFPPDTTELVLTGNNLTALPPGLLDALPALRAAHLGANPWRCDCRLLPLRAWLAGRPERAPYRDLRCVAPPALRGRLLPYVAEDELRAACAPGLLCWGALVAQLALLVLGLLHALLLALLLGRLRRLRARARARSIQEFSLTAPLVAESARGGAS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Methylation	--MGSRPRGALSLLL --CCCCHHHHHHHHH	41.74	-
41	Methylation	GTLVDCGRRGLTWAS CEEEECCCCCCEECC	35.51	-
66	N-linked_Glycosylation	ELVLTGNNLTALPPG EEEEECCCCCCCCCC	39.86	-
186	Phosphorylation	RARARARSIQEFSLT HHHHHHHCCHHHCCC	27.86	25521595
191	Phosphorylation	ARSIQEFSLTAPLVA HHCCHHHCCCHHHHH	24.86	24704852
193	Phosphorylation	SIQEFSLTAPLVAES CCHHHCCCHHHHHHH	25.65	24704852
200	Phosphorylation	TAPLVAESARGGAS- CHHHHHHHHCCCCC-	17.33	19060867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GP1BB_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GP1BB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GP1BB_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of GP1BB_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GP1BB_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-186, AND MASSSPECTROMETRY.	17242355 [Abstract]