G3PT_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: G3PT_MOUSE
• UniProt AC: Q64467
• Protein Name: Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
• Gene Name: Gapdhs
• Organism: Mus musculus (Mouse).
• Sequence Length: 440
• Subcellular Localization: Cytoplasm.
• Protein Description: May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility..
• Protein Sequence: MSRRDVVLTNVTVVQLRRDRCPCPCPCPCPCPCPVIRPPPPKLEDPPPTVEEQPPPPPPPPPPPPPPPPPPPPQIEPDKFEEAPPPPPPPPPPPPPPPPPLQKPARELTVGINGFGRIGRLVLRVCMEKGIRVVAVNDPFIDPEYMVYMFKYDSTHGRYKGNVEHKNGQLVVDNLEINTYQCKDPKEIPWSSIGNPYVVECTGVYLSIEAASAHISSGARRVVVTAPSPDAPMFVMGVNEKDYNPGSMTIVSNASCTTNCLAPLAKVIHENFGIVEGLMTTVHSYTATQKTVDGPSKKDWRGGRGAHQNIIPSSTGAAKAVGKVIPELKGKLTGMAFRVPTPNVSVVDLTCRLAKPASYSAITEAVKAAAKGPLAGILAYTEDQVVSTDFNGNPHSSIFDAKAGIALNDNFVKLVAWYDNEYGYSNRVVDLLRYMFSREK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	SRRDVVLTNVTVVQL CHHCEEEEEEEEEEE	18.94	23984901
12	Phosphorylation	DVVLTNVTVVQLRRD CEEEEEEEEEEECCC	19.61	23984901
183	Ubiquitination	EINTYQCKDPKEIPW EEEEEECCCCCCCCH	62.63	-
241	Ubiquitination	FVMGVNEKDYNPGSM EEEECCCCCCCCCCE	61.38	-
252	Phosphorylation	PGSMTIVSNASCTTN CCCEEEEECCCCCCC	23.87	26239621
255	Phosphorylation	MTIVSNASCTTNCLA EEEEECCCCCCCCHH	19.08	22942356
257	Phosphorylation	IVSNASCTTNCLAPL EEECCCCCCCCHHHH	20.67	22942356
258	Phosphorylation	VSNASCTTNCLAPLA EECCCCCCCCHHHHH	28.41	23984901
266	Ubiquitination	NCLAPLAKVIHENFG CCHHHHHHHHHHHCC	49.78	-
296	Phosphorylation	QKTVDGPSKKDWRGG EEECCCCCCCCCCCC	58.84	23737553
333	Phosphorylation	PELKGKLTGMAFRVP HHHCCCEEEEEEECC	28.53	28542873
338	Methylation	KLTGMAFRVPTPNVS CEEEEEEECCCCCEE	24.78	-
341	Phosphorylation	GMAFRVPTPNVSVVD EEEEECCCCCEEEEE	25.33	26643407
345	Phosphorylation	RVPTPNVSVVDLTCR ECCCCCEEEEEEEEE	24.06	26643407
350	Phosphorylation	NVSVVDLTCRLAKPA CEEEEEEEEEECCCC	7.36	17203969
351	S-nitrosylation	VSVVDLTCRLAKPAS EEEEEEEEEECCCCC	4.34	22178444
351	Glutathionylation	VSVVDLTCRLAKPAS EEEEEEEEEECCCCC	4.34	24333276
351	S-nitrosocysteine	VSVVDLTCRLAKPAS EEEEEEEEEECCCCC	4.34	-
355	Ubiquitination	DLTCRLAKPASYSAI EEEEEECCCCCHHHH	45.79	-
358	Phosphorylation	CRLAKPASYSAITEA EEECCCCCHHHHHHH	28.31	25293948
360	Phosphorylation	LAKPASYSAITEAVK ECCCCCHHHHHHHHH	15.65	25293948
363	Phosphorylation	PASYSAITEAVKAAA CCCHHHHHHHHHHHH	20.01	26239621
381	Phosphorylation	LAGILAYTEDQVVST CCEEEEECCCEEEEE	27.72	26239621
397	Phosphorylation	FNGNPHSSIFDAKAG CCCCCCCCCCCCCCC	25.00	26239621
424	Phosphorylation	WYDNEYGYSNRVVDL EECCCCCCHHHHHHH	11.23	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of G3PT_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of G3PT_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of G3PT_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of G3PT_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-350, AND MASSSPECTROMETRY.
PubMed: 17203969