CYH1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CYH1_MOUSE
• UniProt AC: Q9QX11
• Protein Name: Cytohesin-1
• Gene Name: Cyth1
• Organism: Mus musculus (Mouse).
• Sequence Length: 398
• Subcellular Localization: Cell membrane ; Peripheral membrane protein . Cytoplasm, cytosol . Cell junction, tight junction . Cell junction, adherens junction . Colocalized with TJP1 during epithelial polarization (PubMed:20080746).
• Protein Description: Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. [PubMed: 18042453]
• Protein Sequence: MEDDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKEEIAEVANEIESLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENGLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFSIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNTGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEDWIKCIKAAISRDPFYEMLAARKKKVSSTKRH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEDDDSYV -------CCCCCCCC	13.22	-
50	Phosphorylation	EVANEIESLGSTEER HHHHHHHHCCCHHHH	43.63	20415495
53	Phosphorylation	NEIESLGSTEERKNM HHHHHCCCHHHHHHH	37.63	25521595
54	Phosphorylation	EIESLGSTEERKNMQ HHHHCCCHHHHHHHH	39.81	25521595
79	Ubiquitination	KFNMDPKKGIQFLIE HCCCCHHHHHHHHHH	67.64	-
151	Phosphorylation	ALRQFLWSFRLPGEA HHHHHHHHCCCCCHH	11.57	22609160
160	Ubiquitination	RLPGEAQKIDRMMEA CCCCHHHHHHHHHHH	54.33	-
382	Phosphorylation	AISRDPFYEMLAARK HHHCCHHHHHHHHHH	13.05	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
382	Y	Phosphorylation	Kinase	FYN	P06241	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CYH1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CYH1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CYH1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.