| UniProt ID | CCDC8_MOUSE | |
|---|---|---|
| UniProt AC | D3YZV8 | |
| Protein Name | Coiled-coil domain-containing protein 8 homolog | |
| Gene Name | Ccdc8 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 685 | |
| Subcellular Localization | Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . | |
| Protein Description | Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Required for localization of CUL7 to the centrosome.. | |
| Protein Sequence | MLQIGEDVDYLLIPREVRLAGGVWRVISKPATKEAEFRERLIQFLQEEGRTLEDVARIIEKSTPHPPQPRKRTKELRVRRVPQMVTPPLRLVVGTYDSSNGSDSELSDFDTSKVKGNRSSSGRTRKVRKMPVSYLGSKFLGSDVESEDDQELVEAFLRRGEKPSAPPPRRRVNLPVPMFENNLGPQPSKADRWREYVSQVSWGKLKQRVKGWAPRSGSEVGQTQQASTAAERAGEMRHSQASSDDDSSRNTGDRSDQMLGTRRWKPKIKWVSLRRCRKEQVPPFAQGTGMPAEEHPEAAENQGAEAAANQRAEPLASPRAEAAASPRAETAADPRVEAVASPRAEAAASPRAEAVADPRAEAAASPRAEAAASPRTEAAASLRAEAVASPRAEAAASPRAEAAADPRAEAAASPIAEAAANQKAELVDSPRAETAADPRAEAAASPRAEAVADPRVEAAASPIAEAAANQKAELVDSPRAETAADPRAEAAASPRAEAAADPRAEVAASPRAEAAASPRAEAEASPRAEAAASPKAEAEANLRVEAAAYLRAGVPPDQRAEAIDSQRAEGPANQRTGATENQRVEVLADQRAGVLHDQREEAGPQGIQEASAGSGSRAQKQVKTVRFQTPGRFSWFRMRRRVFWHTPRLPTLPRRVPRAGEARSLRVLRADIRADVEHREQEEQL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 62 | Phosphorylation | VARIIEKSTPHPPQP HHHHHHHCCCCCCCC | 34.09 | 24719451 | |
| 63 | Phosphorylation | ARIIEKSTPHPPQPR HHHHHHCCCCCCCCC | 36.36 | 24719451 | |
| 86 | Phosphorylation | RRVPQMVTPPLRLVV CCCCCCCCCCEEEEE | 17.53 | 24899341 | |
| 95 | Phosphorylation | PLRLVVGTYDSSNGS CEEEEEEEECCCCCC | 16.73 | - | |
| 133 | Phosphorylation | KVRKMPVSYLGSKFL EEECCCHHHHCHHHC | 14.58 | 25777480 | |
| 134 | Phosphorylation | VRKMPVSYLGSKFLG EECCCHHHHCHHHCC | 18.47 | 25777480 | |
| 137 | Phosphorylation | MPVSYLGSKFLGSDV CCHHHHCHHHCCCCC | 20.03 | 25777480 | |
| 142 | Phosphorylation | LGSKFLGSDVESEDD HCHHHCCCCCCCCCH | 40.40 | 23737553 | |
| 146 | Phosphorylation | FLGSDVESEDDQELV HCCCCCCCCCHHHHH | 46.29 | 23737553 | |
| 164 | Phosphorylation | LRRGEKPSAPPPRRR HHCCCCCCCCCCCCC | 65.56 | 28285833 | |
| 242 | Phosphorylation | EMRHSQASSDDDSSR HHCCCCCCCCCCCCC | 27.02 | 29899451 | |
| 243 | Phosphorylation | MRHSQASSDDDSSRN HCCCCCCCCCCCCCC | 48.34 | 26824392 | |
| 413 | Phosphorylation | PRAEAAASPIAEAAA HHHHHHHHHHHHHHH | 16.47 | 25619855 | |
| 461 | Phosphorylation | PRVEAAASPIAEAAA HHHHHHHHHHHHHHH | 16.47 | 28066266 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CCDC8_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CCDC8_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CCDC8_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of CCDC8_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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