TOLIP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TOLIP_MOUSE
• UniProt AC: Q9QZ06
• Protein Name: Toll-interacting protein
• Gene Name: Tollip
• Organism: Mus musculus (Mouse).
• Sequence Length: 274
• Subcellular Localization: Cytoplasm .
• Protein Description: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity)..
• Protein Sequence: MATTVSTQRGPVYIGELPQDFLRITPTQQQQQIQLDAQAAQQLQYGGTVGTVGRLSITVVQAKLAKNYGMTRMDPYCRLRLGYAVYETPTAHNGAKNPRWNKVIQCTVPPGVDSFYLEIFDERAFSMDDRIAWTHITIPESLKQGQVEDEWYSLSGRQGDDKEGMINLVMSYTSLPAAMMMPPQPVVLMPTVYQQGVGYVPIAGMPAVCSPGMVPMAMPPPAVAPQPRCNEEDLKAIQDMFPNMDREVIRSVLEAQRGNKDAAINSLLQMGEES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATTVSTQR ------CCCEECCCC	16.39	-
13	Phosphorylation	STQRGPVYIGELPQD CCCCCCEEEECCCCC	13.32	26032504
45	Phosphorylation	QAAQQLQYGGTVGTV HHHHHHHCCCCCCCC	26.56	29514104
63	Ubiquitination	SITVVQAKLAKNYGM EEEEHHHHHHHHHCC	31.70	-
66	Ubiquitination	VVQAKLAKNYGMTRM EHHHHHHHHHCCCCC	62.23	-
66	Malonylation	VVQAKLAKNYGMTRM EHHHHHHHHHCCCCC	62.23	26320211
96	Ubiquitination	PTAHNGAKNPRWNKV CCCCCCCCCCCCCCE	69.73	-
143	Ubiquitination	ITIPESLKQGQVEDE EECCHHHHCCCCCCE	62.76	-
229	S-nitrosocysteine	AVAPQPRCNEEDLKA CCCCCCCCCHHHHHH	10.79	-
229	S-nitrosylation	AVAPQPRCNEEDLKA CCCCCCCCCHHHHHH	10.79	22178444
235	Ubiquitination	RCNEEDLKAIQDMFP CCCHHHHHHHHHHCC	56.62	-
274	Phosphorylation	LLQMGEES------- HHHHCCCC-------	41.02	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TOLIP_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TOLIP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TOLIP_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.