LONP2_MOUSE - dbPTM
LONP2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LONP2_MOUSE
UniProt AC Q9DBN5
Protein Name Lon protease homolog 2, peroxisomal {ECO:0000255|HAMAP-Rule:MF_03121}
Gene Name Lonp2
Organism Mus musculus (Mouse).
Sequence Length 852
Subcellular Localization Peroxisome matrix .
Protein Description ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1..
Protein Sequence MSSVSPIQIPSRLPLLLTHESVLLPGSTMRTSVDTARNLQLVRSRLLKGTSLQSTILGVIPNTPDPASDTQDLPPLHRIGTAALAVQVVGSNWPKPHYTLLITGLCRFQIVQVLKEKPYPVAEVEQLDRLEEFPNICKSREELGELSEQFYRYAVQLVEMLDMSVPAVAKLRRLLDNLPREALPDILTSIIRTSNKEKLQILDAVSLEDRFKMTIPLLVRQIEGLKLLQKTRKPKQDDDKRVIAIRPIRRIPHIPGTLEDEEEEEDNDDIVMLEKKIRTSSMPEQAHKVCVKEIKRLKKMPQSMPEYALTRNYLELMVELPWNKSTTDRLDIRAARILLDNDHYAMEKLKRRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIALGGVCDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTDHYLNVAFDLSQVLFIATANTTATIPPALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQQIQIPQHTTLAIITRYTREAGVRSLDRKFGAICRAVAVKVAEGQHKEAKLDRSDVADGEGCKEHVLEDAKPESISDTADLALPPEMPILIDSHALKDILGPPLYELEVSERLSQPGVAIGLAWTPLGGKIMFVEASRMDGEGQLTLTGQLGDVMKESAHLAISWLRSNAKKYHLTNAFGSFDLLDNTDIHLHFPAGAVTKDGPSAGVTIVTCLASLFSGRLVRSDVAMTGEITLRGLVLPVGGIKDKVLAAHRAGLKQIIIPQRNEKDLEEIPSNVRQDLSFVTASCLDEVLNAAFDGGFPVKTRPGLIDSKL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSSVSPIQI
------CCCCCCCCC		39.17-
2Phosphorylation------MSSVSPIQI
------CCCCCCCCC		39.1729472430
3Phosphorylation-----MSSVSPIQIP
-----CCCCCCCCCC		25.8929472430
5Phosphorylation---MSSVSPIQIPSR
---CCCCCCCCCCCC		20.4529472430
70PhosphorylationTPDPASDTQDLPPLH
CCCCCCCCCCCCCHH		22.84-
81PhosphorylationPPLHRIGTAALAVQV
CCHHHCCHHHEEEEE		13.34-
137S-palmitoylationLEEFPNICKSREELG
HHHCCCCCCCHHHHH		4.0928526873
138UbiquitinationEEFPNICKSREELGE
HHCCCCCCCHHHHHH		49.0722790023
198UbiquitinationIRTSNKEKLQILDAV
HHCCCHHHHEEEEEC		47.5022790023
279PhosphorylationMLEKKIRTSSMPEQA
EEEHHHHCCCCCHHH		28.7325338131
281PhosphorylationEKKIRTSSMPEQAHK
EHHHHCCCCCHHHHH		37.4323140645
307PhosphorylationMPQSMPEYALTRNYL
CCCCCHHHHHHHHHH		10.8825195567
348UbiquitinationNDHYAMEKLKRRVLE
CCHHHHHHHHHHHHH		46.3422790023
348AcetylationNDHYAMEKLKRRVLE
CCHHHHHHHHHHHHH		46.3423864654
348 (in isoform 2)Acetylation-46.34-
367UbiquitinationRQLKNNLKGPILCFV
HHHHHCCCCCEEEEE		65.8422790023
372S-palmitoylationNLKGPILCFVGPPGV
CCCCCEEEEECCCCC		2.4128526873
405S-palmitoylationRIALGGVCDQSDIRG
HHHHCCCCCHHHCCC		4.4528526873
430UbiquitinationGRIINGLKTVGVNNP
CCEECCCCCCCCCCC		42.4322790023
446UbiquitinationFLLDEVDKLGKSLQG
EEHHHHHHHCHHCCC		65.4022790023
563PhosphorylationTREAGVRSLDRKFGA
HHHHCCCHHHHHHHH		32.0130352176
567UbiquitinationGVRSLDRKFGAICRA
CCCHHHHHHHHHHHH		48.0622790023
612PhosphorylationLEDAKPESISDTADL
HCCCCCCCCCCCCCC		35.6023140645
614PhosphorylationDAKPESISDTADLAL
CCCCCCCCCCCCCCC		37.8823140645
616PhosphorylationKPESISDTADLALPP
CCCCCCCCCCCCCCC		18.4523140645
750PhosphorylationSAGVTIVTCLASLFS
CCCHHHHHHHHHHHC		9.6521454597
751S-palmitoylationAGVTIVTCLASLFSG
CCHHHHHHHHHHHCC		1.7528526873
754PhosphorylationTIVTCLASLFSGRLV
HHHHHHHHHHCCCCC		19.5921454597
757PhosphorylationTCLASLFSGRLVRSD
HHHHHHHCCCCCCCC		28.4421454597
806AcetylationIIPQRNEKDLEEIPS
ECCCCCHHHHHHCCC		71.7766702283
851AcetylationRPGLIDSKL------
CCCCCCCCC------		55.247629363
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LONP2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LONP2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LONP2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of LONP2_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LONP2_MOUSE

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Related Literatures of Post-Translational Modification

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