CHSS2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CHSS2_MOUSE
• UniProt AC: Q6IQX7
• Protein Name: Chondroitin sulfate synthase 2
• Gene Name: Chpf
• Organism: Mus musculus (Mouse).
• Sequence Length: 774
• Subcellular Localization: Isoform 1: Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein . Cytoplasm, cytosol .; Isoform 3: Cytoplasm, cytosol . Mitochondrion .; Isoform 2: Mitochondrion matrix .
• Protein Description: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer (By similarity). Isoform 2 may facilitate PRKN transport into the mitochondria. In collaboration with PRKN, isoform 2 may enhance cell viability and protect cells from oxidative stress (By similarity)..
• Protein Sequence: MRASLLLSVLRPAGPVAVGISLGFTLSLLSVTWVEEPCGPGPPQPGDSELPPRGNTNAARRPNSVQPGSERERPGAGAGTGESWEPRVLPYHPAQPGQATKKAVRTRYISTELGIRQKLLVAVLTSQATLPTLGVAVNRTLGHRLEHVVFLTGARGRRTPSGMAVVALGEERPIGHLHLALRHLLEQHGDDFDWFFLVPDATYTEAHGLDRLAGHLSLASATHLYLGRPQDFIGGDTTPGRYCHGGFGVLLSRTLLQQLRPHLESCRNDIVSARPDEWLGRCILDATGVGCTGDHEGMHYNYLELSPGEPVQEGDPRFRSALTAHPVRDPVHMYQLHKAFARAELDRTYQEIQELQWEIQNTSRLAADGERASAWPVGIPAPSRPASRFEVLRWDYFTEQYAFSCADGSPRCPLRGADQADVADVLGTALEELNRRYQPALQLQKQQLVNGYRRFDPARGMEYTLDLQLEALTPQGGRWPLTRRVQLLRPLSRVEILPVPYVTEASRLTVLLPLAAAERDLASGFLEAFATAALEPGDAAALTLLLLYEPRQAQRAAHSDVFAPVKAHVAELERRFPGARVPWLSVQTAAPSPLRLMDLLSKKHPLDTLFLLAGPDTVLTPDFLNRCRMHAISGWQAFFPMHFQAFHPAVAPPQGPGPPELGRDTGHFDRQAASEACFYNSDYVAARGRLVAASEQEEELLESLDVYELFLRFSNLHVLRAVEPALLQRYRAQPCSARLSEDLYHRCRQSVLEGLGSRTQLAMLLFEQEQGNST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
138	N-linked_Glycosylation	PTLGVAVNRTLGHRL CHHHHHHHCCHHHHC	22.83	-
283	Ubiquitination	DEWLGRCILDATGVG CHHHHCHHHHCCCCC	3.62	-
361	N-linked_Glycosylation	ELQWEIQNTSRLAAD HHHHHHHCHHHHCCC	45.76	-
445	Ubiquitination	QPALQLQKQQLVNGY HHHHHHHHHHHHCCC	48.91	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CHSS2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CHSS2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CHSS2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CHSS2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.