| UniProt ID | NSMA_MOUSE | |
|---|---|---|
| UniProt AC | O70572 | |
| Protein Name | Sphingomyelin phosphodiesterase 2 | |
| Gene Name | Smpd2 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 419 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein. |
|
| Protein Description | Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF (By similarity).. | |
| Protein Sequence | MKLNFSLRLRVFNLNCWDIPYLSKHRADRMKRLGDFLNLENFDLALLEEVWSEQDFQYLRQRLSLTYPDAHYFRSGMIGSGLCVFSKHPIQEIFQHVYSLNGYPYMFHHGDWFCGKSVGLLVLRLSGLVLNAYVTHLHAEYSRQKDIYFAHRVAQAWELAQFIHHTSKNADVVLLCGDLNMHPKDLGCCLLKEWTGLHDAFVETEDFKGSDDGCTMVPKNCYVSQQDLGPFPSGIRIDYVLYKAVSEFHVCCETLKTTTGCDPHSDKPFSDHEALMATLYVKHSPPQEDPCTACGPLERSDLISVLREARTELGLGIAKARWWAAFSGYVIVWGLSLLVLLCVLAAGEEAREVAIILCIPSVGLVLVAGAVYLFHKQEAKGLCRAQAEMLHVLTRETETQDRGSEPHLAYCLQQEGDRA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 176 | S-nitrosocysteine | NADVVLLCGDLNMHP CCCEEEEECCCCCCH | 3.31 | - | |
| 176 | S-nitrosylation | NADVVLLCGDLNMHP CCCEEEEECCCCCCH | 3.31 | 21278135 | |
| 319 | Ubiquitination | ELGLGIAKARWWAAF HHCCCHHHHHHHHHH | 36.24 | 22790023 | |
| 397 | Phosphorylation | LHVLTRETETQDRGS HHHHHCCCCCCCCCC | 40.83 | 30352176 | |
| 399 | Phosphorylation | VLTRETETQDRGSEP HHHCCCCCCCCCCCC | 43.09 | 29899451 | |
| 404 | Phosphorylation | TETQDRGSEPHLAYC CCCCCCCCCCCHHHH | 49.18 | 23140645 | |
| 410 | Phosphorylation | GSEPHLAYCLQQEGD CCCCCHHHHHHHCCC | 10.47 | 23140645 | |
| 411 | S-nitrosocysteine | SEPHLAYCLQQEGDR CCCCHHHHHHHCCCC | 1.99 | - | |
| 411 | S-nitrosylation | SEPHLAYCLQQEGDR CCCCHHHHHHHCCCC | 1.99 | 21278135 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NSMA_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NSMA_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NSMA_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of NSMA_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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