B2L13_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: B2L13_MOUSE
• UniProt AC: P59017
• Protein Name: Bcl-2-like protein 13
• Gene Name: Bcl2l13
• Organism: Mus musculus (Mouse).
• Sequence Length: 434
• Subcellular Localization: Mitochondrion membrane; Single-pass membrane protein.
• Protein Description: May promote the activation of caspase-3 and apoptosis..
• Protein Sequence: MASSTTASLGFHYETKYVVLSYLGLLSQEKQQGPSPPGVQLDVAPQSLNPEVLLKLKSEIEEELKTLDKEVSEAFTSTGFDCHTSPVFSPANPESSIEDCLAHLGERVSQDLKEPLQKALQTILSQPVTYEAYRECTVETAVHASGWNKLLVPLVLLQHLLLELTRRGQEPLRMLLQFGVMYLEEHAAEFIIQQGGWGSVFSLEPEEEEYPGIIAEDSNDIYILPSDNSGQVSPPESPTVTTSWQSESLPVSLSASQSWHTESLPVSLGPESWQQIAMDPEEVKSLDSSGAGEKSENNSSNSDIVHVEKEEVPEEAFPGAAAPLLTQVPTVEAPEMMRAEKTSPTPSVFVELGEEELEAVTARPEAVERAEGAAQLSEERAGSRKKSHTGEAAAVRGAKSGLPAEGKAVLLFGGAAAVAILAVAVGVALALRRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Phosphorylation	QEKQQGPSPPGVQLD HHHHCCCCCCCCEEE	51.02	26060331
47	Phosphorylation	QLDVAPQSLNPEVLL EEECCCCCCCHHHHH	29.11	23140645
65	Acetylation	SEIEEELKTLDKEVS HHHHHHHHHHCHHHH	50.77	23954790
113	Succinylation	ERVSQDLKEPLQKAL HHHCHHHHHHHHHHH	66.62	23954790
136	S-nitrosocysteine	TYEAYRECTVETAVH CHHHHHHCCCEEEHH	3.70	-
136	S-nitrosylation	TYEAYRECTVETAVH CHHHHHHCCCEEEHH	3.70	21278135
145	Phosphorylation	VETAVHASGWNKLLV CEEEHHHCCHHHHHH	29.48	23684622
256	Phosphorylation	LPVSLSASQSWHTES CCCEEEECCCEECCC	22.75	-
258	Phosphorylation	VSLSASQSWHTESLP CEEEECCCEECCCCC	20.52	-
285	Phosphorylation	MDPEEVKSLDSSGAG CCHHHHHCCCCCCCC	42.45	22324799
288	Phosphorylation	EEVKSLDSSGAGEKS HHHHCCCCCCCCCCC	35.64	22324799
289	Phosphorylation	EVKSLDSSGAGEKSE HHHCCCCCCCCCCCC	32.12	25521595
295	Phosphorylation	SSGAGEKSENNSSNS CCCCCCCCCCCCCCC	41.05	25521595
299	Phosphorylation	GEKSENNSSNSDIVH CCCCCCCCCCCCCEE	42.34	25521595
300	Phosphorylation	EKSENNSSNSDIVHV CCCCCCCCCCCCEEE	42.34	25521595
302	Phosphorylation	SENNSSNSDIVHVEK CCCCCCCCCCEEEEH	30.57	25521595
342	Phosphorylation	EMMRAEKTSPTPSVF HHHCCCCCCCCCCEE	31.29	26824392
343	Phosphorylation	MMRAEKTSPTPSVFV HHCCCCCCCCCCEEE	37.53	26824392
345	Phosphorylation	RAEKTSPTPSVFVEL CCCCCCCCCCEEEEE	28.15	27087446
347	Phosphorylation	EKTSPTPSVFVELGE CCCCCCCCEEEEECH	30.57	26824392
361	Phosphorylation	EEELEAVTARPEAVE HHHHHHHHCCHHHHH	24.81	25619855
377	Phosphorylation	AEGAAQLSEERAGSR HHHHHHHCHHHHCCC	25.90	24068923
383	Phosphorylation	LSEERAGSRKKSHTG HCHHHHCCCCCCCCC	39.68	26060331
387	Phosphorylation	RAGSRKKSHTGEAAA HHCCCCCCCCCHHHH	29.35	26824392
389	Phosphorylation	GSRKKSHTGEAAAVR CCCCCCCCCHHHHHH	43.75	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of B2L13_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of B2L13_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of B2L13_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of B2L13_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry.";
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
Mol. Cell. Proteomics 8:904-912(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343, AND MASSSPECTROMETRY.
PubMed: 19131326

"Mitochondrial phosphoproteome revealed by an improved IMAC method andMS/MS/MS.";
Lee J., Xu Y., Chen Y., Sprung R., Kim S.C., Xie S., Zhao Y.;
Mol. Cell. Proteomics 6:669-676(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-387, AND MASSSPECTROMETRY.
PubMed: 17208939