ANPRA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANPRA_MOUSE
• UniProt AC: P18293
• Protein Name: Atrial natriuretic peptide receptor 1
• Gene Name: Npr1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1057
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand..
• Protein Sequence: MPGSRRVRPRLRALLLLPPLLLLRSGHASDLTVAVVLPLTNTSYPWSWARVGPAVELALGRVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYSAAPVGRFTAHWRVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWEHQALVLYADRLGDDRPCFFIVEGLYMRVRERLNITVNHQEFVEGDPDHYTKLLRTVQRKGRVIYICSSPDAFRNLMLLALDAGLTGEDYVFFHLDVFGQSLQGAQGPVPRKPWERDDGQDRRARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTMEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNFNGTSQELMAVSEHRLYWPLGYPPPDIPKCGFDNEDPACNQDHFSTLEVLALVGSLSLVSFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAIGSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQGHTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLSPKEIIERVTRGEQPPFRPSMDLQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGERGCSTRG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	N-linked_Glycosylation	AVVLPLTNTSYPWSW EEEEECCCCCCCCCH	34.41	-
148	Phosphorylation	GIGVKDEYALTTRTG CCCCCCCEEEEECCC	19.62	28576409
151	Phosphorylation	VKDEYALTTRTGPSH CCCCEEEEECCCCCC	13.17	28576409
208	N-linked_Glycosylation	MRVRERLNITVNHQE HHHHHHHCCEECCHH	33.82	-
334	N-linked_Glycosylation	LLADKKFNFTMEDGL HHCCCCCCEECCCCH	40.12	-
375	N-linked_Glycosylation	GTVTDGENITQRMWN CCCCCCCHHHHHHHH	48.41	-
382	N-linked_Glycosylation	NITQRMWNRSFQGVT HHHHHHHHHHCCCCC	22.00	-
423	N-linked_Glycosylation	FRVVLNFNGTSQELM EEEEEEECCCCCEEE	52.32	-
515	Phosphorylation	WEDLQPSSLERHLRS HHHCCHHHHHHHHHH	40.72	-
525	Phosphorylation	RHLRSAGSRLTLSGR HHHHHCCCCEEECCC	24.67	21183079
528	Phosphorylation	RSAGSRLTLSGRGSN HHCCCCEEECCCCCC	20.12	9567
530	Phosphorylation	AGSRLTLSGRGSNYG CCCCEEECCCCCCCC	22.62	9559
534	Phosphorylation	LTLSGRGSNYGSLLT EEECCCCCCCCCCCC	26.05	25293948
536	Phosphorylation	LSGRGSNYGSLLTTE ECCCCCCCCCCCCCC	15.13	21183079
538	Phosphorylation	GRGSNYGSLLTTEGQ CCCCCCCCCCCCCCE	15.17	9565
541	Phosphorylation	SNYGSLLTTEGQFQV CCCCCCCCCCCEEEE	28.26	-
659	Phosphorylation	GSHGNLKSSNCVVDG CCCCCCCCCCEEEEC	29.92	37006521
694	Ubiquitination	QGHTLFAKKLWTAPE CCCCEEHHHCCCHHH	40.85	22790023
694	Acetylation	QGHTLFAKKLWTAPE CCCCEEHHHCCCHHH	40.85	23864654
802	Ubiquitination	LALRKFNKENSSNIL HHHHHHCCCCCCCHH	62.50	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANPRA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANPRA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANPRA_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PLXA1_MOUSE	Plxna1	physical	10520994
SEM3A_MOUSE	Sema3a	physical	10520994

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.