SEM3A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEM3A_MOUSE
• UniProt AC: O08665
• Protein Name: Semaphorin-3A
• Gene Name: Sema3a
• Organism: Mus musculus (Mouse).
• Sequence Length: 772
• Subcellular Localization: Secreted.
• Protein Description: Plays a role in growth cones guidance. May function to pattern sensory projections by selectively repelling axons that normally terminate dorsally. Involved in the development of the olfactory system and in neuronal control of puberty (By similarity)..
• Protein Sequence: MGWFTGIACLFWGVLLTARANYANGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFNLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLEAYNQTHLYACGTGAFHPICTYIEVGHHPEDNIFKLQDSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPRFISAHLIPESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNSKDPKNPIVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPINNRPIMIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSVPKETWHDLEEILLEEMTVFREPTTISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGSSCSRYFPTAKRRTRRQDIRNGDPLTHCSDLQHHDNHHGPSLEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEDRKEEIRMGDHIIRTEQGLLLRSLQKKDSGNYLCHAVEHGFMQTLLKVTLEVIDTEHLEELLHKDDDGDGSKIKEMSSSMTPSQKVWYRDFMQLINHPNLNTMDEFCEQVWKRDRKQRRQRPGHSQGSSNKWKHMQESKKGRNRRTHEFERAPRSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	N-linked_Glycosylation	ITFNGLANSSSYHTF EEECCCCCCCCCEEE	47.68	12925274
125	N-linked_Glycosylation	IKVLEAYNQTHLYAC HHHHHHHHCCCEEEC	47.53	12925274
429	Phosphorylation	MIKTDVNYQFTQIVV EEEECCCCEEEEEEE	12.59	-
463	Phosphorylation	GTVLKVVSVPKETWH CCEEEEEECCHHHCC	35.37	23140645
591	N-linked_Glycosylation	RIIYGVENSSTFLEC HHEEEECCCCCEEEE	38.56	-
693	Phosphorylation	GSKIKEMSSSMTPSQ CHHHHHHHCCCCCCH	21.98	28973931
741	Phosphorylation	RRQRPGHSQGSSNKW HHCCCCCCCCCCHHH	42.00	21659604
745	Phosphorylation	PGHSQGSSNKWKHMQ CCCCCCCCHHHHHHH	49.61	21659604

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEM3A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEM3A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEM3A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SEM3A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Structure of the semaphorin-3A receptor binding module.";
Antipenko A., Himanen J.P., van Leyen K., Nardi-Dei V., Lesniak J.,Barton W.A., Rajashankar K.R., Lu M., Hoemme C., Puschel A.W.,Nikolov D.B.;
Neuron 39:589-598(2003).
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 26-520, GLYCOSYLATION ATASN-53 AND ASN-125, AND DISULFIDE BONDS.
PubMed: 12925274