ETFA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ETFA_MOUSE
• UniProt AC: Q99LC5
• Protein Name: Electron transfer flavoprotein subunit alpha, mitochondrial
• Gene Name: Etfa
• Organism: Mus musculus (Mouse).
• Sequence Length: 333
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism..
• Protein Sequence: MFRAAAPGQLRRAASLLRFQSTLVIAEHANDSLAPITLNTITAAGRLGGEVSCLVAGTKCDKVVQDLCKVAGVAKVLVAQHDAYKGLLPEELTPLILETQKQFSYTHICAGASAFGKNLLPRVAAKLNVAPVSDIIEIKSPDTFVRTIYAGNALCTVKCDEKVKVFSVRGTSFEAAATSGGSASSEKAPSSSSVGISEWLDQKLTKSDRPELTGAKVVVSGGRGLKSGENFKLLYDLADQLHAAVGASRAAVDAGFVPNDMQVGQTGKIVAPELYIAVGISGAIQHLAGMKDSKTIVAINKDPEAPIFQVADYGIVADLFKVVPEMTEILKKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	GQLRRAASLLRFQST HHHHHHHHHHHHHCE	27.27	27149854
53	S-nitrosocysteine	RLGGEVSCLVAGTKC CCCCEEEEEEECCCH	4.24	-
53	S-nitrosylation	RLGGEVSCLVAGTKC CCCCEEEEEEECCCH	4.24	20925432
53	S-palmitoylation	RLGGEVSCLVAGTKC CCCCEEEEEEECCCH	4.24	28526873
58	Phosphorylation	VSCLVAGTKCDKVVQ EEEEEECCCHHHHHH	20.82	22817900
59	Acetylation	SCLVAGTKCDKVVQD EEEEECCCHHHHHHH	39.25	23576753
59	Glutarylation	SCLVAGTKCDKVVQD EEEEECCCHHHHHHH	39.25	24703693
59	Malonylation	SCLVAGTKCDKVVQD EEEEECCCHHHHHHH	39.25	26320211
59	Succinylation	SCLVAGTKCDKVVQD EEEEECCCHHHHHHH	39.25	-
59	Succinylation	SCLVAGTKCDKVVQD EEEEECCCHHHHHHH	39.25	23806337
60	S-nitrosocysteine	CLVAGTKCDKVVQDL EEEECCCHHHHHHHH	6.51	-
60	S-nitrosylation	CLVAGTKCDKVVQDL EEEECCCHHHHHHHH	6.51	20925432
62	Acetylation	VAGTKCDKVVQDLCK EECCCHHHHHHHHHH	54.50	23576753
62	Glutarylation	VAGTKCDKVVQDLCK EECCCHHHHHHHHHH	54.50	24703693
62	Malonylation	VAGTKCDKVVQDLCK EECCCHHHHHHHHHH	54.50	26320211
62	Succinylation	VAGTKCDKVVQDLCK EECCCHHHHHHHHHH	54.50	24315375
68	S-nitrosocysteine	DKVVQDLCKVAGVAK HHHHHHHHHHHCHHH	4.48	-
68	S-nitrosylation	DKVVQDLCKVAGVAK HHHHHHHHHHHCHHH	4.48	21278135
69	Acetylation	KVVQDLCKVAGVAKV HHHHHHHHHHCHHHH	42.28	23806337
69	Glutarylation	KVVQDLCKVAGVAKV HHHHHHHHHHCHHHH	42.28	24703693
69	Malonylation	KVVQDLCKVAGVAKV HHHHHHHHHHCHHHH	42.28	26320211
69	Succinylation	KVVQDLCKVAGVAKV HHHHHHHHHHCHHHH	42.28	-
69	Succinylation	KVVQDLCKVAGVAKV HHHHHHHHHHCHHHH	42.28	23806337
69	Ubiquitination	KVVQDLCKVAGVAKV HHHHHHHHHHCHHHH	42.28	-
75	Acetylation	CKVAGVAKVLVAQHD HHHHCHHHHHHHCHH	33.42	23576753
75	Glutarylation	CKVAGVAKVLVAQHD HHHHCHHHHHHHCHH	33.42	24703693
75	Succinylation	CKVAGVAKVLVAQHD HHHHCHHHHHHHCHH	33.42	23806337
85	Acetylation	VAQHDAYKGLLPEEL HHCHHHHCCCCCHHH	44.81	23576753
85	Succinylation	VAQHDAYKGLLPEEL HHCHHHHCCCCCHHH	44.81	-
85	Succinylation	VAQHDAYKGLLPEEL HHCHHHHCCCCCHHH	44.81	23806337
93	Phosphorylation	GLLPEELTPLILETQ CCCCHHHHHHHHHHC	21.23	26824392
99	Phosphorylation	LTPLILETQKQFSYT HHHHHHHHCCCCCCC	37.31	23984901
101	Acetylation	PLILETQKQFSYTHI HHHHHHCCCCCCCEE	61.81	23576753
101	Succinylation	PLILETQKQFSYTHI HHHHHHCCCCCCCEE	61.81	24315375
105	Nitration	ETQKQFSYTHICAGA HHCCCCCCCEECCCH	12.02	-
109	S-nitrosocysteine	QFSYTHICAGASAFG CCCCCEECCCHHHHC	1.91	-
109	S-nitrosylation	QFSYTHICAGASAFG CCCCCEECCCHHHHC	1.91	22178444
109	S-palmitoylation	QFSYTHICAGASAFG CCCCCEECCCHHHHC	1.91	28526873
117	Acetylation	AGASAFGKNLLPRVA CCHHHHCCCHHHHHH	37.66	23864654
126	Acetylation	LLPRVAAKLNVAPVS HHHHHHHHCCCCCHH	30.75	24062335
126	Succinylation	LLPRVAAKLNVAPVS HHHHHHHHCCCCCHH	30.75	26388266
126	Ubiquitination	LLPRVAAKLNVAPVS HHHHHHHHCCCCCHH	30.75	-
133	Phosphorylation	KLNVAPVSDIIEIKS HCCCCCHHHHEEECC	23.25	21183079
139	Acetylation	VSDIIEIKSPDTFVR HHHHEEECCCCCCEE	43.05	23576753
139	Succinylation	VSDIIEIKSPDTFVR HHHHEEECCCCCCEE	43.05	26388266
139	Ubiquitination	VSDIIEIKSPDTFVR HHHHEEECCCCCCEE	43.05	-
140	Phosphorylation	SDIIEIKSPDTFVRT HHHEEECCCCCCEEE	33.40	26824392
143	Phosphorylation	IEIKSPDTFVRTIYA EEECCCCCCEEEEEC	27.67	26745281
155	S-nitrosocysteine	IYAGNALCTVKCDEK EECCCEEEEEECCCE	3.69	-
155	S-nitrosylation	IYAGNALCTVKCDEK EECCCEEEEEECCCE	3.69	21278135
155	S-palmitoylation	IYAGNALCTVKCDEK EECCCEEEEEECCCE	3.69	28526873
158	Acetylation	GNALCTVKCDEKVKV CCEEEEEECCCEEEE	20.16	23576753
158	Glutarylation	GNALCTVKCDEKVKV CCEEEEEECCCEEEE	20.16	24703693
158	Succinylation	GNALCTVKCDEKVKV CCEEEEEECCCEEEE	20.16	-
158	Succinylation	GNALCTVKCDEKVKV CCEEEEEECCCEEEE	20.16	23806337
162	Acetylation	CTVKCDEKVKVFSVR EEEECCCEEEEEEEE	33.82	23864654
164	Acetylation	VKCDEKVKVFSVRGT EECCCEEEEEEEECC	48.94	23576753
164	Succinylation	VKCDEKVKVFSVRGT EECCCEEEEEEEECC	48.94	26388266
164	Ubiquitination	VKCDEKVKVFSVRGT EECCCEEEEEEEECC	48.94	-
171	Phosphorylation	KVFSVRGTSFEAAAT EEEEEECCEEEHHHH	21.48	23737553
172	Phosphorylation	VFSVRGTSFEAAATS EEEEECCEEEHHHHC	24.74	23737553
178	Phosphorylation	TSFEAAATSGGSASS CEEEHHHHCCCCCCC	24.15	23737553
179	Phosphorylation	SFEAAATSGGSASSE EEEHHHHCCCCCCCC	36.11	25521595
182	Phosphorylation	AAATSGGSASSEKAP HHHHCCCCCCCCCCC	28.62	23737553
184	Phosphorylation	ATSGGSASSEKAPSS HHCCCCCCCCCCCCC	40.50	23737553
185	Phosphorylation	TSGGSASSEKAPSSS HCCCCCCCCCCCCCC	42.72	23737553
187	Acetylation	GGSASSEKAPSSSSV CCCCCCCCCCCCCCC	68.49	23806337
187	Succinylation	GGSASSEKAPSSSSV CCCCCCCCCCCCCCC	68.49	-
187	Succinylation	GGSASSEKAPSSSSV CCCCCCCCCCCCCCC	68.49	23806337
190	Phosphorylation	ASSEKAPSSSSVGIS CCCCCCCCCCCCCHH	47.95	23737553
191	Phosphorylation	SSEKAPSSSSVGISE CCCCCCCCCCCCHHH	26.10	25521595
192	Phosphorylation	SEKAPSSSSVGISEW CCCCCCCCCCCHHHH	33.12	23737553
193	Phosphorylation	EKAPSSSSVGISEWL CCCCCCCCCCHHHHH	26.72	25521595
197	Phosphorylation	SSSSVGISEWLDQKL CCCCCCHHHHHHHHC	19.45	23984901
203	Acetylation	ISEWLDQKLTKSDRP HHHHHHHHCCCCCCC	58.76	23576753
203	Succinylation	ISEWLDQKLTKSDRP HHHHHHHHCCCCCCC	58.76	-
203	Succinylation	ISEWLDQKLTKSDRP HHHHHHHHCCCCCCC	58.76	23806337
203	Ubiquitination	ISEWLDQKLTKSDRP HHHHHHHHCCCCCCC	58.76	-
206	Acetylation	WLDQKLTKSDRPELT HHHHHCCCCCCCCCC	61.88	23806337
206	Succinylation	WLDQKLTKSDRPELT HHHHHCCCCCCCCCC	61.88	23806337
207	Phosphorylation	LDQKLTKSDRPELTG HHHHCCCCCCCCCCC	33.35	25338131
216	Acetylation	RPELTGAKVVVSGGR CCCCCCCEEEEECCC	36.59	23806337
216	Malonylation	RPELTGAKVVVSGGR CCCCCCCEEEEECCC	36.59	26320211
216	Succinylation	RPELTGAKVVVSGGR CCCCCCCEEEEECCC	36.59	-
216	Succinylation	RPELTGAKVVVSGGR CCCCCCCEEEEECCC	36.59	23806337
216	Ubiquitination	RPELTGAKVVVSGGR CCCCCCCEEEEECCC	36.59	-
220	Phosphorylation	TGAKVVVSGGRGLKS CCCEEEEECCCCCCC	24.74	-
226	Acetylation	VSGGRGLKSGENFKL EECCCCCCCCCCHHH	60.27	23576753
226	Glutarylation	VSGGRGLKSGENFKL EECCCCCCCCCCHHH	60.27	24703693
226	Malonylation	VSGGRGLKSGENFKL EECCCCCCCCCCHHH	60.27	26320211
226	Succinylation	VSGGRGLKSGENFKL EECCCCCCCCCCHHH	60.27	-
226	Succinylation	VSGGRGLKSGENFKL EECCCCCCCCCCHHH	60.27	23806337
226	Ubiquitination	VSGGRGLKSGENFKL EECCCCCCCCCCHHH	60.27	27667366
227	Phosphorylation	SGGRGLKSGENFKLL ECCCCCCCCCCHHHH	57.28	22817900
232	Acetylation	LKSGENFKLLYDLAD CCCCCCHHHHHHHHH	49.52	23576753
232	Succinylation	LKSGENFKLLYDLAD CCCCCCHHHHHHHHH	49.52	-
232	Succinylation	LKSGENFKLLYDLAD CCCCCCHHHHHHHHH	49.52	23806337
235	Nitration	GENFKLLYDLADQLH CCCHHHHHHHHHHHH	21.24	-
266	Phosphorylation	NDMQVGQTGKIVAPE CCCCCCCCCCCCCCH	34.22	20495213
281	Phosphorylation	LYIAVGISGAIQHLA HHHHHHHHHHHHHHC	19.08	22817900
294	Glutarylation	LAGMKDSKTIVAINK HCCCCCCCEEEEEEC	53.02	24703693
294	Succinylation	LAGMKDSKTIVAINK HCCCCCCCEEEEEEC	53.02	26388266
294	Ubiquitination	LAGMKDSKTIVAINK HCCCCCCCEEEEEEC	53.02	-
301	Acetylation	KTIVAINKDPEAPIF CEEEEEECCCCCCCE	69.42	24062335
301	Malonylation	KTIVAINKDPEAPIF CEEEEEECCCCCCCE	69.42	26073543
301	Succinylation	KTIVAINKDPEAPIF CEEEEEECCCCCCCE	69.42	-
301	Succinylation	KTIVAINKDPEAPIF CEEEEEECCCCCCCE	69.42	23806337
331	Acetylation	PEMTEILKKK----- HHHHHHHHCC-----	65.27	23864654
331	Succinylation	PEMTEILKKK----- HHHHHHHHCC-----	65.27	23806337
331	Ubiquitination	PEMTEILKKK----- HHHHHHHHCC-----	65.27	-
332	Acetylation	EMTEILKKK------ HHHHHHHCC------	61.34	23201123

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ETFA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ETFA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ETFA_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ETFA_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.