CATA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CATA_MOUSE
• UniProt AC: P24270
• Protein Name: Catalase
• Gene Name: Cat
• Organism: Mus musculus (Mouse).
• Sequence Length: 527
• Subcellular Localization: Peroxisome.
• Protein Description: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells..
• Protein Sequence: MSDSRDPASDQMKQWKEQRASQRPDVLTTGGGNPIGDKLNIMTAGSRGPLLVQDVVFTDEMAHFDRERIPERVVHAKGAGAFGYFEVTHDITRYSKAKVFEHIGKRTPIAVRFSTVTGESGSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDAILFPSFIHSQKRNPQTHLKDPDMVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNADGEAVYCKFHYKTDQGIKNLPVGEAGRLAQEDPDYGLRDLFNAIANGNYPSWTFYIQVMTFKEAETFPFNPFDLTKVWPHKDYPLIPVGKLVLNKNPVNYFAEVEQMAFDPSNMPPGIEPSPDKMLQGRLFAYPDTHRHRLGPNYLQIPVNCPYRARVANYQRDGPMCMHDNQGGAPNYYPNSFSAPEQQRSALEHSVQCAVDVKRFNSANEDNVTQVRTFYTKVLNEEERKRLCENIAGHLKDAQLFIQKKAVKNFTDVHPDYGARIQALLDKYNAEKPKNAIHTYTQAGSHMAAKGKANL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSDSRDPAS ------CCCCCCCHH	44.27	23806337
2	Phosphorylation	------MSDSRDPAS ------CCCCCCCHH	44.27	21743459
4	Phosphorylation	----MSDSRDPASDQ ----CCCCCCCHHHH	31.14	23684622
9	Phosphorylation	SDSRDPASDQMKQWK CCCCCCHHHHHHHHH	33.49	23984901
13	Acetylation	DPASDQMKQWKEQRA CCHHHHHHHHHHHHH	47.58	23806337
13	Succinylation	DPASDQMKQWKEQRA CCHHHHHHHHHHHHH	47.58	-
13	Succinylation	DPASDQMKQWKEQRA CCHHHHHHHHHHHHH	47.58	23806337
13	Ubiquitination	DPASDQMKQWKEQRA CCHHHHHHHHHHHHH	47.58	27667366
16	Acetylation	SDQMKQWKEQRASQR HHHHHHHHHHHHHHC	41.28	23864654
21	Phosphorylation	QWKEQRASQRPDVLT HHHHHHHHHCCCEEE	28.98	25521595
28	Phosphorylation	SQRPDVLTTGGGNPI HHCCCEEECCCCCCC	24.20	23140645
29	Phosphorylation	QRPDVLTTGGGNPIG HCCCEEECCCCCCCC	29.66	23140645
38	Acetylation	GGNPIGDKLNIMTAG CCCCCCCCCEEEECC	37.91	23864654
38	Succinylation	GGNPIGDKLNIMTAG CCCCCCCCCEEEECC	37.91	24315375
38	Ubiquitination	GGNPIGDKLNIMTAG CCCCCCCCCEEEECC	37.91	27667366
43	Phosphorylation	GDKLNIMTAGSRGPL CCCCEEEECCCCCCE	24.86	29472430
46	Phosphorylation	LNIMTAGSRGPLLVQ CEEEECCCCCCEEEE	31.44	23140645
84	Phosphorylation	KGAGAFGYFEVTHDI CCCCCCCEEEEECCC	7.07	26032504
98	Acetylation	ITRYSKAKVFEHIGK CHHHHHHHHHHHHCC	51.71	23806337
98	Succinylation	ITRYSKAKVFEHIGK CHHHHHHHHHHHHCC	51.71	23806337
98	Ubiquitination	ITRYSKAKVFEHIGK CHHHHHHHHHHHHCC	51.71	27667366
105	Acetylation	KVFEHIGKRTPIAVR HHHHHHCCCCCEEEE	53.12	23864654
105	Succinylation	KVFEHIGKRTPIAVR HHHHHHCCCCCEEEE	53.12	23954790
105	Ubiquitination	KVFEHIGKRTPIAVR HHHHHHCCCCCEEEE	53.12	27667366
122	Phosphorylation	TVTGESGSADTVRDP EEECCCCCCCCCCCC	32.05	-
169	Acetylation	PSFIHSQKRNPQTHL HHHHHHCCCCCCCCC	58.10	23864654
169	Succinylation	PSFIHSQKRNPQTHL HHHHHHCCCCCCCCC	58.10	24315375
169	Ubiquitination	PSFIHSQKRNPQTHL HHHHHHCCCCCCCCC	58.10	27667366
174	Phosphorylation	SQKRNPQTHLKDPDM HCCCCCCCCCCCCHH	30.36	30387612
221	Acetylation	GYGSHTFKLVNADGE CCCCEEEEEECCCCC	53.32	23806337
221	Succinylation	GYGSHTFKLVNADGE CCCCEEEEEECCCCC	53.32	-
221	Succinylation	GYGSHTFKLVNADGE CCCCEEEEEECCCCC	53.32	23806337
221	Ubiquitination	GYGSHTFKLVNADGE CCCCEEEEEECCCCC	53.32	-
231	Phosphorylation	NADGEAVYCKFHYKT CCCCCEEEEEEEEEC	9.29	12950161
232	S-nitrosocysteine	ADGEAVYCKFHYKTD CCCCEEEEEEEEECC	2.81	-
232	S-nitrosylation	ADGEAVYCKFHYKTD CCCCEEEEEEEEECC	2.81	21278135
232	S-palmitoylation	ADGEAVYCKFHYKTD CCCCEEEEEEEEECC	2.81	28526873
233	Acetylation	DGEAVYCKFHYKTDQ CCCEEEEEEEEECCC	19.93	23576753
233	Succinylation	DGEAVYCKFHYKTDQ CCCEEEEEEEEECCC	19.93	24315375
237	Acetylation	VYCKFHYKTDQGIKN EEEEEEEECCCCCCC	36.74	23864654
237	Malonylation	VYCKFHYKTDQGIKN EEEEEEEECCCCCCC	36.74	25418362
237	Ubiquitination	VYCKFHYKTDQGIKN EEEEEEEECCCCCCC	36.74	27667366
243	Acetylation	YKTDQGIKNLPVGEA EECCCCCCCCCCCHH	60.29	23576753
243	Glutarylation	YKTDQGIKNLPVGEA EECCCCCCCCCCCHH	60.29	24703693
243	Malonylation	YKTDQGIKNLPVGEA EECCCCCCCCCCCHH	60.29	26320211
243	Ubiquitination	YKTDQGIKNLPVGEA EECCCCCCCCCCCHH	60.29	27667366
291	Phosphorylation	MTFKEAETFPFNPFD EECCCCEECCCCCCC	43.59	23140645
301	Ubiquitination	FNPFDLTKVWPHKDY CCCCCCCCCCCCCCC	49.99	22790023
306	Acetylation	LTKVWPHKDYPLIPV CCCCCCCCCCCEEEC	55.68	23576753
306	Succinylation	LTKVWPHKDYPLIPV CCCCCCCCCCCEEEC	55.68	-
306	Succinylation	LTKVWPHKDYPLIPV CCCCCCCCCCCEEEC	55.68	23806337
306	Ubiquitination	LTKVWPHKDYPLIPV CCCCCCCCCCCEEEC	55.68	27667366
315	Acetylation	YPLIPVGKLVLNKNP CCEEECCEEEECCCC	35.34	23806337
315	Succinylation	YPLIPVGKLVLNKNP CCEEECCEEEECCCC	35.34	23806337
315	Ubiquitination	YPLIPVGKLVLNKNP CCEEECCEEEECCCC	35.34	27667366
337	Phosphorylation	EQMAFDPSNMPPGIE EECCCCCCCCCCCCC	47.83	23140645
349	Ubiquitination	GIEPSPDKMLQGRLF CCCCCCCCCCCCCEE	44.91	22790023
358	Phosphorylation	LQGRLFAYPDTHRHR CCCCEEECCCCCCCC	8.36	23140645
377	S-nitrosocysteine	YLQIPVNCPYRARVA CCCCCCCCCCHHCCC	2.97	-
377	Glutathionylation	YLQIPVNCPYRARVA CCCCCCCCCCHHCCC	2.97	24333276
377	S-nitrosylation	YLQIPVNCPYRARVA CCCCCCCCCCHHCCC	2.97	21278135
377	S-palmitoylation	YLQIPVNCPYRARVA CCCCCCCCCCHHCCC	2.97	28526873
379	Phosphorylation	QIPVNCPYRARVANY CCCCCCCCHHCCCCC	21.07	17242355
386	Phosphorylation	YRARVANYQRDGPMC CHHCCCCCCCCCCCC	8.66	12950161
392	Oxidation	NYQRDGPMCMHDNQG CCCCCCCCCCCCCCC	3.76	17242355
393	S-nitrosocysteine	YQRDGPMCMHDNQGG CCCCCCCCCCCCCCC	2.17	-
393	Glutathionylation	YQRDGPMCMHDNQGG CCCCCCCCCCCCCCC	2.17	24333276
393	S-nitrosylation	YQRDGPMCMHDNQGG CCCCCCCCCCCCCCC	2.17	21278135
393	S-palmitoylation	YQRDGPMCMHDNQGG CCCCCCCCCCCCCCC	2.17	28526873
404	Phosphorylation	NQGGAPNYYPNSFSA CCCCCCCCCCCCCCC	21.17	23140645
405	Phosphorylation	QGGAPNYYPNSFSAP CCCCCCCCCCCCCCH	11.54	17242355
408	Phosphorylation	APNYYPNSFSAPEQQ CCCCCCCCCCCHHHH	18.97	23140645
417	Phosphorylation	SAPEQQRSALEHSVQ CCHHHHHHHHHHHHH	32.63	25521595
422	Phosphorylation	QRSALEHSVQCAVDV HHHHHHHHHHHHHHH	12.42	25521595
425	S-nitrosocysteine	ALEHSVQCAVDVKRF HHHHHHHHHHHHHHH	3.60	-
425	Glutathionylation	ALEHSVQCAVDVKRF HHHHHHHHHHHHHHH	3.60	24333276
425	S-nitrosylation	ALEHSVQCAVDVKRF HHHHHHHHHHHHHHH	3.60	22178444
425	S-palmitoylation	ALEHSVQCAVDVKRF HHHHHHHHHHHHHHH	3.60	28526873
430	Acetylation	VQCAVDVKRFNSANE HHHHHHHHHHCCCCC	46.97	23576753
430	Glutarylation	VQCAVDVKRFNSANE HHHHHHHHHHCCCCC	46.97	24703693
430	Malonylation	VQCAVDVKRFNSANE HHHHHHHHHHCCCCC	46.97	26073543
430	Succinylation	VQCAVDVKRFNSANE HHHHHHHHHHCCCCC	46.97	-
430	Succinylation	VQCAVDVKRFNSANE HHHHHHHHHHCCCCC	46.97	23806337
430	Ubiquitination	VQCAVDVKRFNSANE HHHHHHHHHHCCCCC	46.97	-
434	Phosphorylation	VDVKRFNSANEDNVT HHHHHHCCCCCCCCE	29.74	21082442
441	Phosphorylation	SANEDNVTQVRTFYT CCCCCCCEEEEHHHH	27.83	23140645
445	Phosphorylation	DNVTQVRTFYTKVLN CCCEEEEHHHHHHCC	23.33	23140645
447	Phosphorylation	VTQVRTFYTKVLNEE CEEEEHHHHHHCCHH	12.68	21082442
448	Phosphorylation	TQVRTFYTKVLNEEE EEEEHHHHHHCCHHH	15.53	21183079
449	Acetylation	QVRTFYTKVLNEEER EEEHHHHHHCCHHHH	33.09	23806337
449	Glutarylation	QVRTFYTKVLNEEER EEEHHHHHHCCHHHH	33.09	24703693
449	Malonylation	QVRTFYTKVLNEEER EEEHHHHHHCCHHHH	33.09	26073543
449	Succinylation	QVRTFYTKVLNEEER EEEHHHHHHCCHHHH	33.09	-
449	Succinylation	QVRTFYTKVLNEEER EEEHHHHHHCCHHHH	33.09	23806337
449	Ubiquitination	QVRTFYTKVLNEEER EEEHHHHHHCCHHHH	33.09	-
457	Acetylation	VLNEEERKRLCENIA HCCHHHHHHHHHHHH	53.66	6568495
457	Succinylation	VLNEEERKRLCENIA HCCHHHHHHHHHHHH	53.66	23954790
460	S-nitrosocysteine	EEERKRLCENIAGHL HHHHHHHHHHHHHHH	4.34	-
460	S-nitrosylation	EEERKRLCENIAGHL HHHHHHHHHHHHHHH	4.34	22178444
460	S-palmitoylation	EEERKRLCENIAGHL HHHHHHHHHHHHHHH	4.34	28526873
468	Acetylation	ENIAGHLKDAQLFIQ HHHHHHHHHHHHHHH	45.39	23576753
468	Malonylation	ENIAGHLKDAQLFIQ HHHHHHHHHHHHHHH	45.39	25418362
468	Ubiquitination	ENIAGHLKDAQLFIQ HHHHHHHHHHHHHHH	45.39	-
476	Acetylation	DAQLFIQKKAVKNFT HHHHHHHHHHHCCCC	37.57	23864654
476	Glutarylation	DAQLFIQKKAVKNFT HHHHHHHHHHHCCCC	37.57	24703693
476	Malonylation	DAQLFIQKKAVKNFT HHHHHHHHHHHCCCC	37.57	26320211
476	Ubiquitination	DAQLFIQKKAVKNFT HHHHHHHHHHHCCCC	37.57	-
477	Acetylation	AQLFIQKKAVKNFTD HHHHHHHHHHCCCCC	41.87	23576753
477	Succinylation	AQLFIQKKAVKNFTD HHHHHHHHHHCCCCC	41.87	24315375
480	Acetylation	FIQKKAVKNFTDVHP HHHHHHHCCCCCCCC	51.72	23576753
480	Malonylation	FIQKKAVKNFTDVHP HHHHHHHCCCCCCCC	51.72	26320211
480	Succinylation	FIQKKAVKNFTDVHP HHHHHHHCCCCCCCC	51.72	-
480	Succinylation	FIQKKAVKNFTDVHP HHHHHHHCCCCCCCC	51.72	23806337
480	Ubiquitination	FIQKKAVKNFTDVHP HHHHHHHCCCCCCCC	51.72	-
489	Phosphorylation	FTDVHPDYGARIQAL CCCCCCCHHHHHHHH	19.69	23140645
499	Acetylation	RIQALLDKYNAEKPK HHHHHHHHHCCCCCC	40.13	23576753
499	Glutarylation	RIQALLDKYNAEKPK HHHHHHHHHCCCCCC	40.13	24703693
499	Ubiquitination	RIQALLDKYNAEKPK HHHHHHHHHCCCCCC	40.13	-
500	Phosphorylation	IQALLDKYNAEKPKN HHHHHHHHCCCCCCC	21.19	-
504	Acetylation	LDKYNAEKPKNAIHT HHHHCCCCCCCCCCH	59.90	23864654
504	Succinylation	LDKYNAEKPKNAIHT HHHHCCCCCCCCCCH	59.90	24315375
506	Acetylation	KYNAEKPKNAIHTYT HHCCCCCCCCCCHHH	70.81	23864654
511	Phosphorylation	KPKNAIHTYTQAGSH CCCCCCCHHHHHCCH	23.35	17242355
512	Phosphorylation	PKNAIHTYTQAGSHM CCCCCCHHHHHCCHH	5.23	23140645
513	Phosphorylation	KNAIHTYTQAGSHMA CCCCCHHHHHCCHHH	17.07	23684622
517	Phosphorylation	HTYTQAGSHMAAKGK CHHHHHCCHHHHCCC	17.07	23684622
522	Acetylation	AGSHMAAKGKANL-- HCCHHHHCCCCCC--	51.94	23806337
522	Succinylation	AGSHMAAKGKANL-- HCCHHHHCCCCCC--	51.94	-
522	Succinylation	AGSHMAAKGKANL-- HCCHHHHCCCCCC--	51.94	23806337

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
231	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
231	Y	Phosphorylation	Kinase	ABL2	P42684	GPS
386	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
386	Y	Phosphorylation	Kinase	ABL2	P42684	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CATA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CATA_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CATA_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Mitochondrial phosphoproteome revealed by an improved IMAC method andMS/MS/MS.";
Lee J., Xu Y., Chen Y., Sprung R., Kim S.C., Xie S., Zhao Y.;
Mol. Cell. Proteomics 6:669-676(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21; SER-422 AND SER-517,AND MASS SPECTROMETRY.
PubMed: 17208939