LAD1_MOUSE - dbPTM
LAD1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LAD1_MOUSE
UniProt AC P57016
Protein Name Ladinin-1
Gene Name Lad1
Organism Mus musculus (Mouse).
Sequence Length 528
Subcellular Localization Secreted, extracellular space, extracellular matrix, basement membrane .
Protein Description Anchoring filament protein which is a component of the basement membrane zone..
Protein Sequence MSVSRKDWSALSSLARQRTLEDEEEQERERRRRHRNLSSTTDDESPKLTQNGAQRSVERLPSVEEAEVSKPSPPASKDEDEDFQAILRTRKERRQRRQVVEAVQAPVQERPEAEEERDSLGPEQTSSQPLVPKKKVEALPRRRLSREQRGPWAQDEERLKNRELAEGEKRLPEETVAQQKTLVSEKTPVSEKTPVPAKRLVSEKACPSEKGTATEKASLTEKRHSPEKLVPEKTSVTEKSPVPEKTLVSLKTAAPERRSPPVLEKAIVSEKMQERKLVSEKASIFEKSLVSEAKLTPKKAAVSEQPQTTGGSQATTREPRGRALPDKSPPSSAEQSTPAPPTKASRFPPITLQVKIPSKDEDADTPSPTLLTYSSSLKRSSPRTISFRMSPRKDNSETPLTRSASVRLPASTVKLGEKLERYHTAIQRSESVRSPGSSRTEVLVTPAGVASKRHLFEKELSGQNRTEPTSIRKENLRLSGVVTSRLNLWISKTQDSGDHGSQEVRKEASVTKRAQWGSKPSTSLDAEV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MSVSRKDWSAL
----CCCCHHHHHHH		26.7224719451
19PhosphorylationSSLARQRTLEDEEEQ
HHHHHHCCCCCHHHH		26.5920139300
38PhosphorylationRRRHRNLSSTTDDES
HHHHHCCCCCCCCCC		29.2325521595
39PhosphorylationRRHRNLSSTTDDESP
HHHHCCCCCCCCCCC		38.1928833060
40PhosphorylationRHRNLSSTTDDESPK
HHHCCCCCCCCCCCC		30.7628833060
41PhosphorylationHRNLSSTTDDESPKL
HHCCCCCCCCCCCCC		43.3228833060
45PhosphorylationSSTTDDESPKLTQNG
CCCCCCCCCCCCCCC		34.0428833060
56PhosphorylationTQNGAQRSVERLPSV
CCCCHHHHHHCCCCH		19.0926239621
62PhosphorylationRSVERLPSVEEAEVS
HHHHCCCCHHHHHCC		46.9125521595
69PhosphorylationSVEEAEVSKPSPPAS
CHHHHHCCCCCCCCC		30.2926239621
72PhosphorylationEAEVSKPSPPASKDE
HHHCCCCCCCCCCCC		47.4528507225
76PhosphorylationSKPSPPASKDEDEDF
CCCCCCCCCCCCHHH		46.5422817900
119PhosphorylationEAEEERDSLGPEQTS
HHHHHHHCCCCCCCC		41.2528973931
175PhosphorylationEKRLPEETVAQQKTL
HCCCCHHHHHHHHHH		21.3425367039
181PhosphorylationETVAQQKTLVSEKTP
HHHHHHHHHHCCCCC		28.2325367039
184PhosphorylationAQQKTLVSEKTPVSE
HHHHHHHCCCCCCCC		36.1725367039
187PhosphorylationKTLVSEKTPVSEKTP
HHHHCCCCCCCCCCC		25.5225367039
190PhosphorylationVSEKTPVSEKTPVPA
HCCCCCCCCCCCCCH		34.2825367039
193PhosphorylationKTPVSEKTPVPAKRL
CCCCCCCCCCCHHHH		26.0128973931
204MalonylationAKRLVSEKACPSEKG
HHHHHCCCCCCCCCC		48.0232601280
218PhosphorylationGTATEKASLTEKRHS
CCHHHHHCCCCCCCC		47.0629895711
220PhosphorylationATEKASLTEKRHSPE
HHHHHCCCCCCCCCC		36.6429895711
225PhosphorylationSLTEKRHSPEKLVPE
CCCCCCCCCCCCCCC		38.4926239621
240PhosphorylationKTSVTEKSPVPEKTL
CCCCCCCCCCCHHHE		25.5428507225
252PhosphorylationKTLVSLKTAAPERRS
HHEEECCCCCCCCCC		33.0927087446
259PhosphorylationTAAPERRSPPVLEKA
CCCCCCCCCHHHHHH		39.5127180971
288PhosphorylationKASIFEKSLVSEAKL
HHHHHHHHHHHCCCC		27.1424719451
296PhosphorylationLVSEAKLTPKKAAVS
HHHCCCCCCCCCCCC		32.1526239621
328PhosphorylationGRALPDKSPPSSAEQ
CCCCCCCCCCCCCCC		49.8027087446
331PhosphorylationLPDKSPPSSAEQSTP
CCCCCCCCCCCCCCC		45.6326239621
332PhosphorylationPDKSPPSSAEQSTPA
CCCCCCCCCCCCCCC		41.4126239621
336PhosphorylationPPSSAEQSTPAPPTK
CCCCCCCCCCCCCCC		28.0626239621
337PhosphorylationPSSAEQSTPAPPTKA
CCCCCCCCCCCCCCH		24.1426239621
358PhosphorylationTLQVKIPSKDEDADT
EEEEECCCCCCCCCC		57.1026239621
365PhosphorylationSKDEDADTPSPTLLT
CCCCCCCCCCCCEEE		27.6426239621
367PhosphorylationDEDADTPSPTLLTYS
CCCCCCCCCCEEEEC		32.3927087446
369PhosphorylationDADTPSPTLLTYSSS
CCCCCCCCEEEECCC		38.4426239621
372PhosphorylationTPSPTLLTYSSSLKR
CCCCCEEEECCCCCC		25.1928833060
373PhosphorylationPSPTLLTYSSSLKRS
CCCCEEEECCCCCCC		13.4126239621
374PhosphorylationSPTLLTYSSSLKRSS
CCCEEEECCCCCCCC		14.2826239621
375PhosphorylationPTLLTYSSSLKRSSP
CCEEEECCCCCCCCC		29.3126239621
376PhosphorylationTLLTYSSSLKRSSPR
CEEEECCCCCCCCCC		31.7826239621
386PhosphorylationRSSPRTISFRMSPRK
CCCCCEEEEEECCCC		13.2428973931
390PhosphorylationRTISFRMSPRKDNSE
CEEEEEECCCCCCCC		19.8024719451
401PhosphorylationDNSETPLTRSASVRL
CCCCCCCCCCCEEEC		24.6320469934
403PhosphorylationSETPLTRSASVRLPA
CCCCCCCCCEEECCH		21.4728833060
405PhosphorylationTPLTRSASVRLPAST
CCCCCCCEEECCHHH		14.7121082442
411PhosphorylationASVRLPASTVKLGEK
CEEECCHHHHHHHHH		31.6228833060
412PhosphorylationSVRLPASTVKLGEKL
EEECCHHHHHHHHHH		24.6228833060
422PhosphorylationLGEKLERYHTAIQRS
HHHHHHHHHHHHHHC		8.3130165576
424PhosphorylationEKLERYHTAIQRSES
HHHHHHHHHHHHCHH		19.2724719451
429PhosphorylationYHTAIQRSESVRSPG
HHHHHHHCHHCCCCC		20.1830165576
431PhosphorylationTAIQRSESVRSPGSS
HHHHHCHHCCCCCCC		24.8726239621
434PhosphorylationQRSESVRSPGSSRTE
HHCHHCCCCCCCCCE		31.3025195567
437PhosphorylationESVRSPGSSRTEVLV
HHCCCCCCCCCEEEE		21.7430635358
438PhosphorylationSVRSPGSSRTEVLVT
HCCCCCCCCCEEEEE		49.4930635358
445PhosphorylationSRTEVLVTPAGVASK
CCCEEEEECCCHHHH		11.8527600695
451PhosphorylationVTPAGVASKRHLFEK
EECCCHHHHHHHHHH		28.0229899451
479PhosphorylationRKENLRLSGVVTSRL
HHHCCCCCCEEEEEE		24.0926239621
483PhosphorylationLRLSGVVTSRLNLWI
CCCCCEEEEEEEEEE		13.0125195567
484PhosphorylationRLSGVVTSRLNLWIS
CCCCEEEEEEEEEEE		24.1428973931
491PhosphorylationSRLNLWISKTQDSGD
EEEEEEEECCCCCCC		20.3325195567
493PhosphorylationLNLWISKTQDSGDHG
EEEEEECCCCCCCCC		30.7123375375
496PhosphorylationWISKTQDSGDHGSQE
EEECCCCCCCCCCHH		35.9823375375
518PhosphorylationTKRAQWGSKPSTSLD
HCCCCCCCCCCCCCC		38.1330635358
521PhosphorylationAQWGSKPSTSLDAEV
CCCCCCCCCCCCCCC		34.0726239621
522PhosphorylationQWGSKPSTSLDAEV-
CCCCCCCCCCCCCC-		41.6626239621
523PhosphorylationWGSKPSTSLDAEV--
CCCCCCCCCCCCC--		28.7021082442
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LAD1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LAD1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LAD1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of LAD1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LAD1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56 AND SER-62, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-523, AND MASSSPECTROMETRY.

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