dbPTM

GEM_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GEM_MOUSE
UniProt AC	P55041
Protein Name	GTP-binding protein GEM
Gene Name	Gem
Organism	Mus musculus (Mouse).
Sequence Length	295
Subcellular Localization	Cell membrane Peripheral membrane protein Cytoplasmic side.
Protein Description	Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity..
Protein Sequence	MTLNNVTMRQGTVGMQPQQRWSIPADARHLMVQKDPHPCNLRNRHSTAPEEHCRRSWSSDSTDSVISSESGNTYYRVVLIGEQGVGKSTLANIFAGVHDSMDSDCEVLGEDTYERTLVVDGESATIILLDMWENKGENEWLHDHCMQVGDAYLIVYSITDRASFEKASELRIQLRRARQTEDIPIILVGNKSDLVRCREVSVSEGRACAVVFDCKFIETSAAVQHNVKELFEGIVRQVRLRRDSKEKNERRLAYQKRRESIPRKARRFWGKIVAKNNKNMAFKLKSKSCHDLSVL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	MQPQQRWSIPADARH CCCCCCCCCCCCCCE	22.38	23684622
46	Phosphorylation	CNLRNRHSTAPEEHC CCCCCCCCCCCHHHH	24.03	25266776
47	Phosphorylation	NLRNRHSTAPEEHCR CCCCCCCCCCHHHHH	39.86	25266776
56	Phosphorylation	PEEHCRRSWSSDSTD CHHHHHCCCCCCCCC	16.38	24759943
260	Phosphorylation	AYQKRRESIPRKARR HHHHHHHHCCHHHHH	35.76	29472430
286	Phosphorylation	NMAFKLKSKSCHDLS CCEEEEECCCCCCCC	39.99	25168779
288	Phosphorylation	AFKLKSKSCHDLSVL EEEEECCCCCCCCCC	24.63	26824392
293	Phosphorylation	SKSCHDLSVL----- CCCCCCCCCC-----	27.68	25168779

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GEM_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GEM_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GEM_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of GEM_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GEM_MOUSE

Related Literatures of Post-Translational Modification