ELMO1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ELMO1_MOUSE
• UniProt AC: Q8BPU7
• Protein Name: Engulfment and cell motility protein 1
• Gene Name: Elmo1
• Organism: Mus musculus (Mouse).
• Sequence Length: 727
• Subcellular Localization: Cytoplasm. Cell membrane. Translocation to plasma membrane seems to be mediated by DOCK1 and CRK..
• Protein Description: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity)..
• Protein Sequence: MPPPSDIVKVAIEWPGAYPKLMEIDQKKPLSAIIKEVCDGWSLANHEYFALQHADSSNFYITEKNRNEIKNGTILRLTTSPAQNAQQLHERIQSSSMDAKLEALKDLASLSRDVTFAQEFINLDGISLLTQMVESGTERYQKLQKIMKPCFGDMLSFTLTAFVELMDHGIVSWDTFSVAFIKKIASFVNKSAIDISILQRSLAILESMVLNSHDLYQKVAQEITIGQLIPHLQGTDQEIQTYTIAVINALFLKAPDERRQEMANILAQKQLRYIILTHVIRAQRAINNEMAHQLYVLQVLTFNLLEDRMMTKMDPQDQAQRDIIFELRRIAFDAESEPNNSSGSMEKRKSMYTRDYKKLGFINHVNPAMDFTQTPPGMLALDNMLYFAKHHQDAYIRIVLENSSREDKHECPFGRSSIELTKMLCEILKVGELPSETCNDFHPMFFTHDRSFEEFFCICIQLLNKTWKEMRATSEDFNKVMQVVKEQVMRALTTKPSSLDQFKSKLQNLSYTEILKIRQSERMNQEDFQSRPILELKEKIQPEILELIKQQRLNRLVEGTCFRKLNARRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVPHDSLQDKLPVADIKAVVTGKDCPHMKEKGALKQNKEVLELAFSILYDSNCQLNFIAPDKHEYCIWTDGLNALLGKDMMSDLTRNDLDTLLSMEIKLRLLDLENIQIPDAPPPIPKEPSNYDFVYDCN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Ubiquitination	PPPSDIVKVAIEWPG CCCHHHEEEEEECCC	26.70	27667366
18	Phosphorylation	AIEWPGAYPKLMEID EEECCCCCCCHHHHC	13.55	-
31	Phosphorylation	IDQKKPLSAIIKEVC HCCCCCHHHHHHHHH	26.42	28833060
59	Ubiquitination	QHADSSNFYITEKNR ECCCCCCEEEEECCC	5.15	27667366
69	Ubiquitination	TEKNRNEIKNGTILR EECCCCCCCCCCEEE	4.85	27667366
100	Acetylation	QSSSMDAKLEALKDL HHCCHHHHHHHHHHH	42.47	-
105	Acetylation	DAKLEALKDLASLSR HHHHHHHHHHHHHCC	58.71	-
105	Ubiquitination	DAKLEALKDLASLSR HHHHHHHHHHHHHCC	58.71	27667366
216	Phosphorylation	VLNSHDLYQKVAQEI HCCCHHHHHHHHHHC	16.61	-
336	Phosphorylation	RIAFDAESEPNNSSG HHHHCCCCCCCCCCC	61.14	28833060
341	Phosphorylation	AESEPNNSSGSMEKR CCCCCCCCCCCCHHH	42.59	25521595
342	Phosphorylation	ESEPNNSSGSMEKRK CCCCCCCCCCCHHHH	36.69	26824392
344	Phosphorylation	EPNNSSGSMEKRKSM CCCCCCCCCHHHHHH	26.22	25521595
350	Phosphorylation	GSMEKRKSMYTRDYK CCCHHHHHHHHCCHH	22.51	23375375
353	Phosphorylation	EKRKSMYTRDYKKLG HHHHHHHHCCHHHHC	14.39	29550500
395	Phosphorylation	AKHHQDAYIRIVLEN HHHCCCCEEEEEEEC	10.06	-
443	Ubiquitination	ETCNDFHPMFFTHDR CCCCCCCCCCCCCCC	22.67	27667366
453	Ubiquitination	FTHDRSFEEFFCICI CCCCCCHHHHHHHHH	55.96	27667366
511	Phosphorylation	SKLQNLSYTEILKIR HHHHCCCHHHHHHHH	16.14	-
516	Ubiquitination	LSYTEILKIRQSERM CCHHHHHHHHHHHHC	41.31	-
539	Ubiquitination	PILELKEKIQPEILE CHHHHHHHHCHHHHH	45.08	27667366
549	Ubiquitination	PEILELIKQQRLNRL HHHHHHHHHHHHHHH	53.67	27667366
554	Ubiquitination	LIKQQRLNRLVEGTC HHHHHHHHHHHHCCH	37.11	27667366
564	Ubiquitination	VEGTCFRKLNARRRQ HHCCHHHHHCCCHHC	26.32	27667366
588	Phosphorylation	PNHKVLHYGDLEESP CCCCEEECCCCCCCC	14.26	20415495
594	Phosphorylation	HYGDLEESPQGEVPH ECCCCCCCCCCCCCC	17.10	22817900
603	Phosphorylation	QGEVPHDSLQDKLPV CCCCCCCCHHCCCCH	25.54	20415495
618	Phosphorylation	ADIKAVVTGKDCPHM HHEEEEEECCCCHHH	31.73	22817900
622	Glutathionylation	AVVTGKDCPHMKEKG EEEECCCCHHHHHCC	2.58	24333276
695	Ubiquitination	TLLSMEIKLRLLDLE HHHHHHHHHHHHCCC	17.78	-
718	Phosphorylation	PPIPKEPSNYDFVYD CCCCCCCCCCCCCEE	49.46	29899451
720	Phosphorylation	IPKEPSNYDFVYDCN CCCCCCCCCCCEECC	18.33	29899451
724	Phosphorylation	PSNYDFVYDCN---- CCCCCCCEECC----	18.12	30635358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
18	Y	Phosphorylation	Kinase	HCK	P08103	Uniprot
216	Y	Phosphorylation	Kinase	HCK	P08103	Uniprot
395	Y	Phosphorylation	Kinase	HCK	P08103	Uniprot
511	Y	Phosphorylation	Kinase	HCK	P08103	Uniprot
720	Y	Phosphorylation	Kinase	HCK	P08103	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ELMO1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ELMO1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ELMO1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.