| UniProt ID | RFOX1_MOUSE | |
|---|---|---|
| UniProt AC | Q9JJ43 | |
| Protein Name | RNA binding protein fox-1 homolog 1 | |
| Gene Name | Rbfox1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 396 | |
| Subcellular Localization | Nucleus. Cytoplasm. Predominantly nuclear. | |
| Protein Description | RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.. | |
| Protein Sequence | MNCEREQLRGNQEAAAAPDTMAQPYASAQFAPPQNGIPAEYTAPHPHPAPEYTGQTTVPDHTLNLYPPTQTHSEQSADTSAQTVSGTATQTDDAAPTDGQPQTQPSENTESKSQPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKTVNPYTNGWKLNPVVGAVYSPDFYAGTVLLCQANQEGSSMYSGPSSLVYTSAMPGFPYPAATAAAAYRGAHLRGRGRTVYNTFRAAAPPPPIPAYGGVVYQDGFYGADIYGGYAAYRYAQPTPATAAAYSDSYGRVYAADPYHHTLAPAPTYGVGAMNAFAPLTDAKTRSHADDVGLVLSSLQASIYRGGYNRFAPY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 174 | Ubiquitination | DADRAREKLHGTVVE CHHHHHHHHCCEEEE | 39.98 | 22790023 | |
| 174 (in isoform 3) | Ubiquitination | - | 39.98 | 22790023 | |
| 174 (in isoform 7) | Phosphorylation | - | 39.98 | - | |
| 180 (in isoform 7) | Phosphorylation | - | 6.92 | - | |
| 184 | Ubiquitination | GTVVEGRKIEVNNAT CEEEECCEEEECCCE | 54.82 | 22790023 | |
| 184 (in isoform 3) | Ubiquitination | - | 54.82 | 22790023 | |
| 194 (in isoform 3) | Ubiquitination | - | 5.28 | - | |
| 199 | Ubiquitination | ARVMTNKKTVNPYTN EEEECCCCCCCCCCC | 60.83 | 22790023 | |
| 199 (in isoform 3) | Ubiquitination | - | 60.83 | 22790023 | |
| 204 (in isoform 3) | Ubiquitination | - | 13.97 | - | |
| 219 (in isoform 3) | Ubiquitination | - | 16.05 | - | |
| 316 | Methylation | YGGYAAYRYAQPTPA ECCEEEEECCCCCCC | 18.65 | 24129315 | |
| 316 | Asymmetric dimethylarginine | YGGYAAYRYAQPTPA ECCEEEEECCCCCCC | 18.65 | - | |
| 331 | Phosphorylation | TAAAYSDSYGRVYAA CCHHHCCCCCCEEEE | 24.44 | - | |
| 337 (in isoform 3) | Dimethylation | - | 11.52 | - | |
| 337 (in isoform 3) | Methylation | - | 11.52 | 24129315 | |
| 368 | Methylation | PLTDAKTRSHADDVG CCCCCCCCCCHHHHH | 26.24 | - | |
| 387 | Methylation | SLQASIYRGGYNRFA HHHHHHHCCCCCCCC | 30.32 | 24129315 | |
| 392 | Methylation | IYRGGYNRFAPY--- HHCCCCCCCCCC--- | 22.18 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RFOX1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RFOX1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RFOX1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of RFOX1_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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