TAP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAP1_MOUSE
• UniProt AC: P21958
• Protein Name: Antigen peptide transporter 1
• Gene Name: Tap1
• Organism: Mus musculus (Mouse).
• Sequence Length: 724
• Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein. The transmembrane segments seem to form a pore in the membrane.
• Protein Description: Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity)..
• Protein Sequence: MAAHVWLAAALLLLVDWLLLRPMLPGIFSLLVPEVPLLRVWVVGLSRWAILGLGVRGVLGVTAGAHGWLAALQPLVAALSLALPGLALFRELAAWGTLREGDSAGLLYWNSRPDAFAISYVAALPAAALWHKLGSLWAPSGNRDAGDMLCRMLGFLGPKKRRLYLVLVLLILSCLGEMAIPFFTGRITDWILQDKTVPSFTRNIWLMSILTIASTALEFASDGIYNITMGHMHGRVHREVFRAVLRQETGFFLKNPAGSITSRVTEDTANVCESISGTLSLLLWYLGRALCLLVFMFWGSPYLTLVTLINLPLLFLLPKKLGKVHQSLAVKVQESLAKSTQVALEALSAMPTVRSFANEEGEAQKFRQKLEEMKTLNKKEALAYVAEVWTTSVSGMLLKVGILYLGGQLVIRGAVSSGNLVSFVLYQLQFTQAVQVLLSLYPSMQKAVGSSEKIFEYLDRTPCSPLSGSLAPSNMKGLVEFQDVSFAYPNQPKVQVLQGLTFTLHPGTVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGQCLVQYDHHYLHTQVAAVGQEPLLFGRSFRENIAYGLNRTPTMEEITAVAVESGAHDFISGFPQGYDTEVGETGNQLSGGQRQAVALARALIRKPLLLILDDATSALDAGNQLRVQRLLYESPKRASRTVLLITQQLSLAEQAHHILFLREGSVGEQGTHLQLMKRGGCYRAMVEALAAPAD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
196	Phosphorylation	DWILQDKTVPSFTRN HHHHCCCCCCCCHHH	46.03	30482847
254	Ubiquitination	QETGFFLKNPAGSIT HHCCEEECCCCCCCE	56.58	22790023
365	Ubiquitination	NEEGEAQKFRQKLEE CCCHHHHHHHHHHHH	49.95	22790023
453	Ubiquitination	KAVGSSEKIFEYLDR HHHCCHHHHHHHHCC	55.43	22790023
461	Phosphorylation	IFEYLDRTPCSPLSG HHHHHCCCCCCCCCC	28.45	28833060
464	Phosphorylation	YLDRTPCSPLSGSLA HHCCCCCCCCCCCCC	30.03	28833060
467	Phosphorylation	RTPCSPLSGSLAPSN CCCCCCCCCCCCCCC	29.71	28833060
469	Phosphorylation	PCSPLSGSLAPSNMK CCCCCCCCCCCCCCC	20.27	28833060
501	Phosphorylation	VQVLQGLTFTLHPGT EEEEECEEEEECCCE	22.77	25777480
503	Phosphorylation	VLQGLTFTLHPGTVT EEECEEEEECCCEEE	20.94	25777480
508	Phosphorylation	TFTLHPGTVTALVGP EEEECCCEEEEEECC	21.09	25777480
510	Phosphorylation	TLHPGTVTALVGPNG EECCCEEEEEECCCC	17.70	25777480
518	Phosphorylation	ALVGPNGSGKSTVAA EEECCCCCCHHHHHH	50.08	25777480
664	Phosphorylation	VQRLLYESPKRASRT HHHHHHHCCCHHHHH	23.36	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TAP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TAP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TAP1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
B2MG_MOUSE	B2m	physical	19366690

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.