TAP1_MOUSE - dbPTM
TAP1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TAP1_MOUSE
UniProt AC P21958
Protein Name Antigen peptide transporter 1
Gene Name Tap1
Organism Mus musculus (Mouse).
Sequence Length 724
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein. The transmembrane segments seem to form a pore in the membrane.
Protein Description Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity)..
Protein Sequence MAAHVWLAAALLLLVDWLLLRPMLPGIFSLLVPEVPLLRVWVVGLSRWAILGLGVRGVLGVTAGAHGWLAALQPLVAALSLALPGLALFRELAAWGTLREGDSAGLLYWNSRPDAFAISYVAALPAAALWHKLGSLWAPSGNRDAGDMLCRMLGFLGPKKRRLYLVLVLLILSCLGEMAIPFFTGRITDWILQDKTVPSFTRNIWLMSILTIASTALEFASDGIYNITMGHMHGRVHREVFRAVLRQETGFFLKNPAGSITSRVTEDTANVCESISGTLSLLLWYLGRALCLLVFMFWGSPYLTLVTLINLPLLFLLPKKLGKVHQSLAVKVQESLAKSTQVALEALSAMPTVRSFANEEGEAQKFRQKLEEMKTLNKKEALAYVAEVWTTSVSGMLLKVGILYLGGQLVIRGAVSSGNLVSFVLYQLQFTQAVQVLLSLYPSMQKAVGSSEKIFEYLDRTPCSPLSGSLAPSNMKGLVEFQDVSFAYPNQPKVQVLQGLTFTLHPGTVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGQCLVQYDHHYLHTQVAAVGQEPLLFGRSFRENIAYGLNRTPTMEEITAVAVESGAHDFISGFPQGYDTEVGETGNQLSGGQRQAVALARALIRKPLLLILDDATSALDAGNQLRVQRLLYESPKRASRTVLLITQQLSLAEQAHHILFLREGSVGEQGTHLQLMKRGGCYRAMVEALAAPAD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
196PhosphorylationDWILQDKTVPSFTRN
HHHHCCCCCCCCHHH
46.0330482847
254UbiquitinationQETGFFLKNPAGSIT
HHCCEEECCCCCCCE
56.5822790023
365UbiquitinationNEEGEAQKFRQKLEE
CCCHHHHHHHHHHHH
49.9522790023
453UbiquitinationKAVGSSEKIFEYLDR
HHHCCHHHHHHHHCC
55.4322790023
461PhosphorylationIFEYLDRTPCSPLSG
HHHHHCCCCCCCCCC
28.4528833060
464PhosphorylationYLDRTPCSPLSGSLA
HHCCCCCCCCCCCCC
30.0328833060
467PhosphorylationRTPCSPLSGSLAPSN
CCCCCCCCCCCCCCC
29.7128833060
469PhosphorylationPCSPLSGSLAPSNMK
CCCCCCCCCCCCCCC
20.2728833060
501PhosphorylationVQVLQGLTFTLHPGT
EEEEECEEEEECCCE
22.7725777480
503PhosphorylationVLQGLTFTLHPGTVT
EEECEEEEECCCEEE
20.9425777480
508PhosphorylationTFTLHPGTVTALVGP
EEEECCCEEEEEECC
21.0925777480
510PhosphorylationTLHPGTVTALVGPNG
EECCCEEEEEECCCC
17.7025777480
518PhosphorylationALVGPNGSGKSTVAA
EEECCCCCCHHHHHH
50.0825777480
664PhosphorylationVQRLLYESPKRASRT
HHHHHHHCCCHHHHH
23.36-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TAP1_MOUSE !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TAP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TAP1_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
B2MG_MOUSEB2mphysical
19366690

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TAP1_MOUSE

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Related Literatures of Post-Translational Modification

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