UniProt ID | TAP1_MOUSE | |
---|---|---|
UniProt AC | P21958 | |
Protein Name | Antigen peptide transporter 1 | |
Gene Name | Tap1 | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 724 | |
Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein. The transmembrane segments seem to form a pore in the membrane. |
|
Protein Description | Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity).. | |
Protein Sequence | MAAHVWLAAALLLLVDWLLLRPMLPGIFSLLVPEVPLLRVWVVGLSRWAILGLGVRGVLGVTAGAHGWLAALQPLVAALSLALPGLALFRELAAWGTLREGDSAGLLYWNSRPDAFAISYVAALPAAALWHKLGSLWAPSGNRDAGDMLCRMLGFLGPKKRRLYLVLVLLILSCLGEMAIPFFTGRITDWILQDKTVPSFTRNIWLMSILTIASTALEFASDGIYNITMGHMHGRVHREVFRAVLRQETGFFLKNPAGSITSRVTEDTANVCESISGTLSLLLWYLGRALCLLVFMFWGSPYLTLVTLINLPLLFLLPKKLGKVHQSLAVKVQESLAKSTQVALEALSAMPTVRSFANEEGEAQKFRQKLEEMKTLNKKEALAYVAEVWTTSVSGMLLKVGILYLGGQLVIRGAVSSGNLVSFVLYQLQFTQAVQVLLSLYPSMQKAVGSSEKIFEYLDRTPCSPLSGSLAPSNMKGLVEFQDVSFAYPNQPKVQVLQGLTFTLHPGTVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGQCLVQYDHHYLHTQVAAVGQEPLLFGRSFRENIAYGLNRTPTMEEITAVAVESGAHDFISGFPQGYDTEVGETGNQLSGGQRQAVALARALIRKPLLLILDDATSALDAGNQLRVQRLLYESPKRASRTVLLITQQLSLAEQAHHILFLREGSVGEQGTHLQLMKRGGCYRAMVEALAAPAD | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
196 | Phosphorylation | DWILQDKTVPSFTRN HHHHCCCCCCCCHHH | 46.03 | 30482847 | |
254 | Ubiquitination | QETGFFLKNPAGSIT HHCCEEECCCCCCCE | 56.58 | 22790023 | |
365 | Ubiquitination | NEEGEAQKFRQKLEE CCCHHHHHHHHHHHH | 49.95 | 22790023 | |
453 | Ubiquitination | KAVGSSEKIFEYLDR HHHCCHHHHHHHHCC | 55.43 | 22790023 | |
461 | Phosphorylation | IFEYLDRTPCSPLSG HHHHHCCCCCCCCCC | 28.45 | 28833060 | |
464 | Phosphorylation | YLDRTPCSPLSGSLA HHCCCCCCCCCCCCC | 30.03 | 28833060 | |
467 | Phosphorylation | RTPCSPLSGSLAPSN CCCCCCCCCCCCCCC | 29.71 | 28833060 | |
469 | Phosphorylation | PCSPLSGSLAPSNMK CCCCCCCCCCCCCCC | 20.27 | 28833060 | |
501 | Phosphorylation | VQVLQGLTFTLHPGT EEEEECEEEEECCCE | 22.77 | 25777480 | |
503 | Phosphorylation | VLQGLTFTLHPGTVT EEECEEEEECCCEEE | 20.94 | 25777480 | |
508 | Phosphorylation | TFTLHPGTVTALVGP EEEECCCEEEEEECC | 21.09 | 25777480 | |
510 | Phosphorylation | TLHPGTVTALVGPNG EECCCEEEEEECCCC | 17.70 | 25777480 | |
518 | Phosphorylation | ALVGPNGSGKSTVAA EEECCCCCCHHHHHH | 50.08 | 25777480 | |
664 | Phosphorylation | VQRLLYESPKRASRT HHHHHHHCCCHHHHH | 23.36 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TAP1_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TAP1_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TAP1_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
B2MG_MOUSE | B2m | physical | 19366690 |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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