P5CR1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: P5CR1_MOUSE
• UniProt AC: Q922W5
• Protein Name: Pyrroline-5-carboxylate reductase 1, mitochondrial
• Gene Name: Pycr1
• Organism: Mus musculus (Mouse).
• Sequence Length: 309
• Subcellular Localization: Mitochondrion .
• Protein Description: Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress (By similarity)..
• Protein Sequence: MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDQATVSALRKIGVNLTPHNKETVRHSDVLFLAVKPHIIPFILDEIGANIEDRHIVVSCAAGVTINSIEKKLTAFQPAPKVIRCMTNTPVVVREGVTVYATGTHAQVEDGRLVEQLMGSVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLDSEQHPSQLKDNVCSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQTMADQETISPAAIKKTVLDKVKLDSSAGASLSSDHVKPLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSVGFIGAG ------CCCCCCCHH	30.83	-
233	Phosphorylation	QLKDNVCSPGGATIH HCCCCCCCCCCHHEE	23.46	-
278	Phosphorylation	MADQETISPAAIKKT HHCCCCCCHHHHHHH	18.86	-
301	Phosphorylation	SSAGASLSSDHVKPL CCCCCCCCCCCCCCC	31.09	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of P5CR1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of P5CR1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of P5CR1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of P5CR1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.