ST17B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ST17B_MOUSE
• UniProt AC: Q8BG48
• Protein Name: Serine/threonine-protein kinase 17B
• Gene Name: Stk17b
• Organism: Mus musculus (Mouse).
• Sequence Length: 372
• Subcellular Localization: Nucleus. Cell membrane. Endoplasmic reticulum-Golgi intermediate compartment. Colocalizes with STK17B at the plasma membrane..
• Protein Description: Acts as a positive regulator of apoptosis. Phosphorylates myosin light chains (By similarity)..
• Protein Sequence: MSRRRFDCRSVSGLLTTTPQTPIKTENFNNFYTLTPKELGRGKFAVVRQCISKSTGQEYAAKSLKKRRRGQDCRAEILHEIAVLELARSCPHVINLHEVYENATEIILVLEYAAGGEIFNLCLPELAEMVSENDVIRLIKQILEGVHYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGNASELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEEMFSSVSQLATDFIQSLLVKNPEKRPTAESCLSHSWLQQWDFGSLFHPEETSGSSQIQDLTLRSSEEKTSKSSCNGSCGAREDKENIPEDGSLVSKRFRFDDSLPSPHELVPDLFC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	RRRFDCRSVSGLLTT CCCCCCCCCCCCCCC	27.28	27180971
12	Phosphorylation	RFDCRSVSGLLTTTP CCCCCCCCCCCCCCC	25.60	25266776
16	Phosphorylation	RSVSGLLTTTPQTPI CCCCCCCCCCCCCCC	33.40	28066266
328	Phosphorylation	SEEKTSKSSCNGSCG CCCCCCCCCCCCCCC	39.63	22817900
333	Phosphorylation	SKSSCNGSCGAREDK CCCCCCCCCCCCCCC	8.72	22817900
348	Phosphorylation	ENIPEDGSLVSKRFR CCCCCCCCEECCEEC	37.61	22817900
351	Phosphorylation	PEDGSLVSKRFRFDD CCCCCEECCEECCCC	24.33	22817900
359	Phosphorylation	KRFRFDDSLPSPHEL CEECCCCCCCCHHHC	43.98	23984901
362	Phosphorylation	RFDDSLPSPHELVPD CCCCCCCCHHHCCCC	44.15	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
10	S	Phosphorylation	Kinase	STK17B	Q8BG48	GPS
12	S	Phosphorylation	Kinase	STK17B	Q8BG48	GPS
328	S	Phosphorylation	Kinase	STK17B	Q8BG48	GPS
333	S	Phosphorylation	Kinase	STK17B	Q8BG48	GPS
348	S	Phosphorylation	Kinase	STK17B	Q8BG48	GPS
351	S	Phosphorylation	Kinase	STK17B	Q8BG48	GPS
362	S	Phosphorylation	Kinase	STK17B	Q8BG48	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ST17B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ST17B_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ST17B_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.